Calcium phosphate microcapsules for paediatric drug delivery

This poster was presented by Galvita at EuPFI 2024 in Rotterdam

Introduction

Modern drug delivery needs to use novel multifunctional materials for developing medicinal products and new therapies.[1] Porous particles attract a lot of attention as promising drug delivery systems. Functions of porous particles are directly related to their surface properties, specific surface area, morphology, size and pore size distribution.[2] Our previous works have shown that porous functionalized calcium carbonate particles are a prototype material with several functions, i.e., they can be used as filler, disintegrant, tablet hardness enhancer, and encapsulation carrier at the same time. Besides the multifunctionality, it is a biocompatible, biodegradable, and non-toxic compound. On the other hand, we have identified some downsides, such as a limited encapsulation efficiency.[3-4] The latter results in drug depositions on the carrier’s surface, which leads to a loss of material multifunctionality as the physicochemical properties change.

Aim

Galvita provides a novel easy-loadable inorganic carrier material for paediatric drug delivery:
Template-InvertedParticles(TIP).

Concept

Clinical evaluation

Ivermectin loaded TIP

Less inter subject variability in drug exposure[5]
Excellent palatability and acceptability
On going clinical studies: NCT05894057, NCT04716335 and NCT04508166

Drug loading

The cavity of TIP is loaded with API using a solvent evaporation approach. Loading is preferably performed using a fluidized bed equipment or a rotary evaporator.

Characterization of drug-loaded TIP. a)FIB-SEM cross-section of ibuprofen (IBU) loaded TIP. Drugload 45% (v/v). b) Drug release from drug-loaded TIP (red) compar fed to drug TIP mixtures in artificial saliva. c) Drug release from drug-loaded TIP (red) compared to drug TIP mixtures in simulated gastric fluid.

Tablet characterization

Tensile strength & Disintegration time

Tablet features

Conclusion

TIP isa monomaterial, consistingofpure tricalciumphosphatein theform ofhydroxyapatite
Template InvertedParticles(TIP) microcapsulesarea platformtechnologyforthedevelopmentofODTs
Drug-loadedTIP microcapsuleshavean excellentcompactability
The maximal drugloadingcapacityis45% (v/v)
TIP tabletsarewellacceptedin patients, particularlyin paediatrics, and havelessintersubjectvariabilityin drugexposure

See the full poster on “Calcium phosphate microcapsules” here

(click the picture to download the poster)

Source: Galvita, J. Kost, J. Huwyler, M. Puchkov, poster “Calcium phosphate microcapsules”

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