Design of Experiments for the Development of Topical Drug Products
The systematic development of pharmaceutical products using quality tools is highly essential for attaining robust performance by minimizing variability. Design of experiment (DoE) is now considered as an indispensable tool in pharmaceutical development to obtain quality products. Among a variety of dosage forms, the topical dosage forms are useful for providing a localized therapeutic effect of the drugs.
Such dosage forms include liposomes, ethosomes, niosomes, transfersomes, and many more, where the manufacturing of such dosage forms includes multifunctional excipients and a number of unit operations. Hence, the use of DoE provides greater flexibility and is highly effective for the efficient development of topical products with ultimate savings of the resources. The present chapter, therefore, provides a holistic account on the implementation of DoE approach for the manufacturing of topical drug products and also highlights the current challenges and opportunities associated with them.
Article information: Chaurawal N., Raza K. (2021) Design of Experiments for the Development of Topical Drug Products. In: Beg S. (eds) Design of Experiments for Pharmaceutical Product Development. Springer, Singapore. https://doi.org/10.1007/978-981-33-4351-1_3