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Dry Powder Inhalers (DPI)
Evaluation of the stability of a spray-dried tuberculosis vaccine candidate designed for dry powder…
Particle engineering via spray drying was used to develop a dry powder presentation of an adjuvanted tuberculosis vaccine candidate. This presentation utilizing a trileucine-trehalose excipient system was designed to be both thermostable and suitable for respiratory delivery. The stability of the…
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Pulmonary Drug Delivery of Antimicrobials and Anticancer Drugs Using Solid Dispersions
It is well established that currently available inhaled drug formulations are associated with extremely low lung deposition. Currently available technologies alleviate this low deposition problem via mixing the drug with inert larger particles, such as lactose monohydrate. Those inert particles are…
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The Development of Thin-film Freezing and Its Application to Improve Delivery of Biologics as Dry…
While the formulation of pharmaceuticals as liquids is common practice, powders are associated with enhanced stability, avoidance of the cold chain, lower dosing requirements, and more convenient administration. These are particularly critical for proteins, as they are expensive and complicated to…
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Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin…
Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) were recently developed. In the present study, the storage stability of CNL powders consisting of lyoprotectant (i.e. sucrose or lactose), lipids, ciprofloxacin (CIP), and magnesium…
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Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier…
Purpose
Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle engineering processes to produce D-mannitol carriers for…
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Does Magnesium Stearate influence the electrical charge of lactose powder?
GranuTools was present in 2 sessions at the #PBPWorldMeeting. Granutools highlighted the dramatic influence of electrostatic charges in pharmaceutical processes. The GranuCharge, developed by GranuTools, can help the industry to measure the triboelectric properties of powders and to investigate the…
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Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for…
To develop stable and inhalable dry powder formulations with long shelf life, polyplexes consisting of siRNA and a polyethylenimine (PEI)‐based block copolymer in presence of mannitol or trehalose are spray dried. The effect of inlet (T‐In) and outlet (T‐Out) temperature on the recovery of siRNA and…
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World Asthma Day 2021
World Asthma Day (WAD) (May 5, 2021) is organized by the Global Initiative for Asthma, (GINA) (www.ginasthma.org), a World Health Organization collaborative organization founded in 1993. WAD is held each May to raise awareness of Asthma worldwide.
WHO recognizes that asthma is of major public…
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Preparation and evaluation of vancomycin spray dried powders for pulmonary delivery
The aim of the current study was to achieve a dry powder formulation of vancomycin by spray drying whilst evaluating the effect of pH and excipient type and percentage used in formulation on particle characteristics and aerosolization performance. A D-optimal design was applied to optimize the…
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A meticulous overview on drying-based (spray-, freeze-, and spray-freeze) particle engineering…
Drying is an indispensable operation in the preparation of pharmaceutical powders and always remained one of the energetic tasks in the pharmaceutical industry. Improving the stability, solubility, and dissolution of pharmaceutical products are being prime objectives of the drying process, intending…
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