Browsing Category
Dry Powder Inhalers (DPI)
Novel dry powder inhaler formulation containing antibiotic using combined technology to improve…
25. July 2018 Dry Powder Inhaler (DPI) could offer a propellant-free, easy-to-use powder form ensuring better stability than liquid dosae forms. Therefore the development of traditional…
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Dosing challenges in respiratory therapies
07. July 2018
The pulmonary route of administration has been commonly used for local lung conditions such as asthma and chronic obstructive pulmonary disease (COPD). Recently, with the advent of new technologies available for both formulation and device design,…
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Inhalation Insights – DPI Technology Symposium
19. June 2018
2018 | July 5 | Kuala Lumpur | Malaysia
Why attend?
First-hand knowledge related to DPI technology along the complete process chain (from powder characteristics and formulations, filling technologies, device design assembly and packaging)…
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Formulation Techniques for High Dose Dry Powders
23. May 2018 Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases. Though DPIs are widely used for thepulmonary deposition of…
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Influence of excipients on physical and aerosolization stability of spray dried high-dose powder…
23. April 2018 The aim of this study is to investigate the influence of excipients on physical and aerosolization stability of spray dried Ciprofloxacin dry powder inhaler formulations. The model drug, Ciprofloxacin hydrochloride,…
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Limitations of high dose carrier based formulations
15. April 2018 This study was performed to investigate how increasing the active pharmaceutical ingredient (API) content within a formulation affects the dispersion of particles and the aerosol performance efficiency of a carrier…
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The influence of lactose on the powder behavior and aerodynamic performance of bosentan…
13. March 2018 Abstract In this study, we prepared carrier-based formulations for dry powder inhalers by mixing bosentan microparticles with carrier, prepared in three separate types of lactose. Spray-dried, milled and sieved…
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Sodium stearate for moisture protection of hygroscopic spray-dried powders
06. March 2018 Abstract Amorphous powders are thermodynamically unstable, significantly impacting the processing, storage and performance of a product. Therefore, stabilization of the amorphous contents is in demand. In this…
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Permeability and the Performance of Carrier-Based Dry Powder Inhalation Mixtures
26. February 2018 The permeability of a powder bed reflects its particle size distribution, shape, packing, porosity, cohesivity, and tensile strength in a manner relevant to powder fluidization. The relationship between the…
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Dry-powder formulations of non-covalent protein complexes
10. February 2018
Abstract
Pulmonary delivery of protein therapeutics has considerable clinical potential for treating both local and systemic diseases. However, poor protein conformational stability, immunogenicity and protein degradation by proteolytic enzymes in the lung are…
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