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Dry Powder Inhalers (DPI)
Challenge to optimize a powder/DPI combination for inhalation delivery of a bi-component generic…
08. February 2018 Development of bi-component generic orally inhaled product (OIP) delivered from dry powder inhaler (DPI) is challenging due to the necessity to demonstrate the similarity of size distribution of both APIs in…
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Dry Powder Inhaler: Probing the Particulate Microstructure of the Aerodynamic Particle Size in…
03. January 2018 Abstract The in vitro aerosol performance of two combination dry powder inhaler (DPI) products, Foster® NEXThaler® and Seretide® Diskus® were investigated with single particle aerosol mass spectrometry (SPAMS).…
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Novel spray-dried lactose-leucine tailored to enhance the aerosolization performance in DPI…
24. December 2017 Abstract Spray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10%…
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Mechanism of Magnesium Stearate to Modify Aerosol Performance in DPI Formulations
20. December 2017 Abstract The potential of the force control agent (FCA) magnesium stearate (MgSt) to enhance the aerosol performance of lactose-based dry powder inhaled (DPI) formulations was investigated in this study. The…
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Powder flow analysis: A simple method to indicate the ideal amount of lactose fines in DPI…
06. November 2017 Abstract Many efforts have been made in the past to understand the function of lactose fines which are given as a ternary component to carrier-based dry powder inhaler formulations. It is undisputed that fines…
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Dry powder inhaler for pulmonary drug delivery
17. October 2017
Pulmonary drug delivery is the promising delivery route to treat not only respiratory diseases but also systemic diseases and has proven as a potential delivery route for complex drugs that cannot be delivered orally. Development of dry powder inhalation…
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Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the…
03. May 2017 Abstract An optimum carrier rugosity is essential to achieve a satisfying drug deposition efficiency for the carrier based dry powder inhalation (DPI). Therefore, a non-organic spray drying technique was firstly…
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Dry powder inhalation: past, present and future
24. March 2017 Abstract Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficient…
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Optimizing drug delivery in COPD: The role of inhaler devices
29. January 2017 Background Inhaled medication is the cornerstone of the pharmacological treatment for patients with asthma and chronic obstructive pulmonary disease (COPD). Several inhaler devices exist, and each device has…
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