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Dry Powder Inhalers (DPI)
Stepping into small shoes: Gaining user perspective on appropriate administration devices for…
A cross sectional pan-India study about use of administration devices for paediatric oral and inhalation medicines was conducted with a diverse pool of participants of various age groups. Via 634 respondents from more than 15 states in India, this study has identified the administration devices…
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Evaluation of the Effects of Storage Conditions on Spray-Dried siRNA-LNPs Before and after…
In an ideal world, pharmaceutical drugs would have infinite shelf life, no susceptibility to degradation, chemical reactions or loss of efficacy. In reality, these processes occur, however, making it desirable to extend a drugs’ shelf life. Nucleic acid-based drugs are most commonly stored as…
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Integrated continuous manufacturing of inhalable remdesivir nanoagglomerate dry powders: design,…
While inhalable nanoparticle-based dry powders have demonstrated promising potential as next-generation respiratory medicines, erratic particle redispersibility, and poor manufacturing reproducibility remain major hurdles hindering their translation from bench to bedside. We developed a one-step…
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Inhalable dry powder product (DPP) of mRNA lipid nanoparticles (LNPs) for pulmonary delivery
Abstract
Pulmonary delivery of mRNA via inhalation is a very attractive approach for RNA-based therapy for treatment of lung diseases. In this work, we have demonstrated successful development of an mRNA-lipid nanoparticle (LNP) dry powder product (DPP), wherein the LNPs were spray dried using…
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Putting children first: Understanding caregivers’ and children’s perspectives on the usability of…
A multi-national online survey was developed to obtain feedback on users’ experiences of administration devices for oral and inhaled paediatric medicines. The questionnaire was divided into two identical parts: 1) for caregivers looking after children aged 0–18 years, and 2) for children aged 10 …
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Inhalable dry powder containing lipid polymer hybrid nanoparticles of Nintedanib esylate: In vitro…
The key objective of this research work was to develop and evaluate dry powder for inhalation containing lipid polymer hybrid nanoparticles (LPHNPs) loaded with Nintedanib esylate (NE) to target deep lung for the treatment of idiopathic pulmonary fibrosis (IPF). NE loaded LPHNPs (NE-LPHNPs) were…
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Advancement of a High-Dose Infant Air-Jet Dry Powder Inhaler (DPI) with Passive Cyclic Loading:…
There is a current medical need for a dry powder aerosol delivery device that can be used to efficiently and consistently administer high dose therapeutics, such as inhaled antibiotics, surfactants and antivirals, to the lungs of infants. This study considered an infant air-jet dry powder inhaler…
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Spray Dried Progesterone Formulations for Carrier Free Dry Powder Inhalation
Low oral absorption and extensive first pass metabolism of progesterone is reported for many oral formulations which warrants investigation into other routes of administration. It is the aim of this study to investigate the generation of inhaled formulations of progesterone though a spray drying…
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Lipid-based particle engineering via spray-drying for targeted delivery of antibiotics to the lung
Pulmonary delivery of antibiotics for the treatment of tuberculosis provides several benefits compared to conventional oral and parenteral administration. API-loaded particles delivered directly to alveolar macrophages, where Mycobacterium tuberculosis resides, can reduce the required dose and…
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Porous Particle Technology: Novel Approaches to Deep Lung Delivery – Chapter 5
Pulmonary Drug Delivery Systems: Material and Technological Advances
See the new book, edited by Piyush Pradeep Mehta and Vividha Dhapte -Pawar
Description:
Brings new technologies & material advances together in pulmonary drug delivery systems
Emphasis on critical aspects of…
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