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Dry Powder Inhalers (DPI)
Exploring the influence of magnesium stearate content and mixing modality on the rheological…
Since carrier-based dry powder inhalers (DPIs) suffer from inadequate drug deposition in the lung, an increasing number of marketed products have added magnesium stearate (MgSt) to improve the aerosolization, dispersion, and stability against moisture of DPI. However, for carrier-based DPI, there is…
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Fixed-dose dry powder for inhalation of nintedanib, pirfenidone and mycophenolic acid by thin-film…
Nintedanib and pirfenidone have been approved to treat idiopathic pulmonary fibrosis (IPF) by delaying progression of the disease. Recently, mycophenolic acid has also been used as an additive treatment for IPF. This study aims to produce and evaluate fixed-dose combinations (i.e., two-drug and…
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Elucidation of the using condition and working mechanism of tertiary lactose in dry powder…
Tertiary lactose has been shown to improve aerosolization performance of carrier-based dry powder inhalation formulations. The working mechanism of the tertiary lactose, however, is still unclear, even the optimal working condition of the lactose fines. Two strategies to incorporate the tertiary…
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Development of an ethanol-free salbutamol sulfate metered-dose inhaler: Application of molecular…
Abstract
Introduction
More than fifty years after the commercialization of the Ventolin metered-dose inhaler (MDI), its constituent active ingredient, salbutamol sulfate (SS), remains the most prescribed short-acting beta agonist for the first-line treatment of acute asthma attacks and the…
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A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances,…
Abstract
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug delivery. However, designing DPIs with adequate physicochemical properties is challenging. The development of novel pulmonary drug delivery systems requires the selection of suitable particle…
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MEGGLE’s sieved, milled and micronized alpha-lactose monyhydrate for dry powder inhalation: InhaLac®
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible immediate and sustained release pharmaceutical solid dosage…
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MEGGLE presents the new DPI product InhaLac® 180 at RDD Europe 2023
Wasserburg, Germany, May, 2023:
Pharmaceutical lactose specialist MEGGLE Excipients will launch its latest inhalable milled lactose grade, InhaLac® 180 at May’s Respiratory Drug Delivery (RDD) in the South of France.
InhaLac® 180 is tailored to dry powder inhalation (DPI) applications with a…
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Twin-screw continuous mixing: Effect of mixing elements and processing parameters on properties of…
Twin-screw continuous mixing was used to prepare aerosol powders containing 1% budesonide, 0.3% magnesium stearate, and 98.7% α-lactose monohydrate. The effect of mixing configuration was studied using three screw profiles containing either a combing element, 30° forward kneading element, or a 60° …
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A ready-to-use dry powder formulation based on protamine nanocarriers for pulmonary drug delivery
The use of oral antibiotic therapy for the treatment of respiratory diseases such as tuberculosis has promoted the appearance of side effects as well as resistance to these treatments. The low solubility, high metabolism, and degradation of drugs such as rifabutin, have led to the use of combined…
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Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of…
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