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Dry Powder Inhalers (DPI)
Inhaled dry powder cisplatin increases antitumour response to anti-PD1 in a murine lung cancer model
Despite advances in targeted therapies and immunotherapy in lung cancer, chemotherapy remains the backbone of treatment in most patients at different stages of the disease. Inhaled chemotherapy is a promising strategy to target lung tumours and to limit the induced severe systemic toxicities.…
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Correlation of brittle matrix powder properties to aerodynamic performance of inhaled nintedanib…
Nintedanib is a drug approved to treat idiopathic pulmonary fibrosis (IPF) and all chronic progressive fibrosing interstitial lung diseases. Delivery by dry powder inhalation appears to be a potential route to improve efficacy and safety over the oral administration. Inhaled nintedanib powders…
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Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations
The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved…
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Phospholipids in Pharmaceutical Form Line Extensions
The pharmaceutical industry has two main ways to generate new products. The first option is to look for new drug substances. A second option is to employ better formulations of an existing drug product. Such reformulated products are called Pharmaceutical Form Line Extensions. As part of such a…
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Amorphicity and Aerosolization of Soluplus-Based Inhalable Spray Dried Powders
Soluplus is a polymer that has been explored to prepare nanocomposites for pulmonary drug delivery and is non-toxic. However, its aerosolization attributes when spray-dried have not been investigated. Hence, this work aimed to investigate the aerosol performance of soluplus-based spray-dried…
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The General Court annuls the Commission Delegated Regulation of 2019 in so far as it concerns the…
Judgment of the General Court in Joined Cases T-279/20, T-288/20 and T-283/20 | CWS Powder Coatings
and Others v Commission
First, the Commission made a manifest error in its assessment of the reliability and acceptability of the study on which the classification was based and, second, it…
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Elucidation of the effect of added fines on the performance of dry powder inhalation formulations
Dry powder inhalers (DPIs) are regularly used to treat respiratory diseases. Adding extrinsic fine excipient particles to the blend of active pharmaceutical ingredient (API) and carrier is an established strategy to improve aerosolization efficiency during pulmonary drug delivery. Different amounts…
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MicroceLac® 100 – MEGGLE’s co-processed lactose grades for direct compression
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible immediate and sustained release pharmaceutical solid dosage…
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Milled and Sieved Lactose – MEGGLE’s crystalline alpha-lactose monohydrate grades
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible immediate and sustained release pharmaceutical solid dosage…
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Development of a High-Dose Infant Air-Jet Dry Powder Inhaler (DPI) with Passive Cyclic Loading of…
Purpose
The objective of this study was to incorporate a passive cyclic loading strategy into the infant air-jet dry powder inhaler (DPI) in a manner that provides high efficiency aerosol lung delivery and is insensitive to powder mass loadings and the presence of downstream pulmonary mechanics.…
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