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Dry Powder Inhalers (DPI)
Inhalable dry powder mRNA vaccines based on extracellular vesicles
Respiratory diseases are a global burden, with millions of deaths attributed to pulmonary illnesses and dysfunctions. Therapeutics have been developed, but they present major limitations regarding pulmonary bioavailability and product stability. To circumvent such limitations, we developed…
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Development of excipients free inhalable co-spray-dried tobramycin and diclofenac formulations for…
This study aims to investigate the effect of physicochemical properties and aerosol performance of two (2FN) and three-fluid nozzles (3FN) on the inhalable co-formulation of tobramycin and diclofenac dry powders. Combination formulations of tobramycin and diclofenac at 2:1 and 4:1 w/w ratios were…
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Engineered inhalable micro-balloon shaped drug particles for carrier-free dry powder inhalation…
The study presents inhalable balloon-like hollow spherical salbutamol sulfate micro-particles (SSμb) as potential carrier-free alternative to drug-excipient formulation for dry powder inhalation. SSμb is engineered from commercial salbutamol sulfate (SS, active pharmaceutical ingredient) through…
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Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a…
Purpose
This study evaluated the in vitro aerosol performance of a dry powder antibiotic product that combined a highly dispersible tobramycin powder with a previously optimized pediatric air-jet dry powder inhaler (DPI) across a subject age range of 2–10 years.
Methods
An excipient enhanced…
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High dose nanocrystalline solid dispersion powder of voriconazole for inhalation
In the current work, we aimed to deliver high dose of voriconazole (VRC) to lung through dry powder for inhalation (DPIs). Furthermore, the research tested the hypothesis that drug nanocrystals can escape the clearance mechanisms in lung by virtue of their size and rapid dissolution. High dose…
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Development of a novel method for the continuous blending of carrier-based dry powders for…
Twin-screw extruders are useful in tuning certain product characteristics due to the ability to greatly modify screw profiles as well as operating parameters. However, their use has not yet been applied to dry powder inhalation. In this study the feasibility of using a twin-screw extruder to blend…
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Capsule-Based dry powder inhaler evaluation using CFD-DEM simulations and next generation impactor…
Capsule-based, single-dose dry powder inhalers (DPIs) are commonly-used devices to deliver medications to the lungs. This work evaluates the effect of the drug/excipient adhesive bonding and the DPI resistances on the aerosol performance using a combination of empirical multi-stage impactor data and…
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State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the…
Commercially available dry powder inhalers (DPIs) are usually devices in a fixed combination with the intended formulation, and a change in medication by the physician often forces the patient to use a different device, requiring the patient to relearn how to use it, resulting in lower adherence and…
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Simultaneous Spray Drying for Combination Dry Powder Inhaler Formulations
Spray drying is a particle engineering technique used to manufacture respirable pharmaceutical powders that are suitable for delivery to the deep lung. It is amenable to processing both small molecules and biologic actives, including proteins. In this work, a simultaneous spray-drying process,…
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Lactose – a muti-talent Excipient
Meggle took a closer look at the multi-functional excipient lactose. Have a look at the background information for lactose as a pharmaceutical excipient:
Multi-talent milk – Components at a glance
Besides fat, minerals, proteins, and water, a very specific sugar is one of the main components of…
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