Application of Insoluble Excipients in Solid Dispersion of Chinese Medicines
In recent years, as the great success of arteannuin in the area of antimalarial treatment and commercial benefit, traditional Chinese medicine (TCM) has received great attention. However, most of the active pharmaceutical ingredients (API) of Chinese medicines are hydrophobic, which causes the low oral bioavailability of Chinese medicine and extremely limits their application. To ameliorate the solubility of the hydrophobic ingredients, many strategies have been developed.
Solid dispersion is considered as dosage forms with good industrial feasibility, and some of the solid dispersions have been already commercially available. In the technologies/researches of solid dispersions, excipients play a vital role by affecting the interaction of excipients-drugs and the in vitro and in vivo fate of preparations by influencing the preparation process, stability, dissolution, and finally absorption and then enhancing the oral bioavailability. Most of the researches and commercially available productions of solid dispersion focused on the hydrophilic excipients such as PEG, PVP, etc.
However, some of the hydrophobic excipients used in the solid dispersions could lead to unexpected result such as improvement of the dissolution rate, the fluidity, and the storage stability of the powder and then increase the feasibility of further industrial processing into solid dosage form of tablets or capsules. Thus, here we focus on the application of hydrophobic excipients in solid dispersion of Chinese medicine and elaborate it from three aspects including excipient types, preparation methods, and application forms.
Article information: Wu H., Lv H., Zhang Z. (2021) Application of Insoluble Excipients in Solid Dispersion of Chinese Medicines. In: Feng N., Yang Z. (eds) Novel Drug Delivery Systems for Chinese Medicines. Springer, Singapore. https://doi.org/10.1007/978-981-16-3444-4_12