Excipients for Lubrication
During tablet and capsule production, lubricants are necessary to improve powder flow and reduce friction and adherence. Lubrication is a critical step since over- or underlubrication is responsible for many production and quality issues. Therefore, lubricant type, quantity, and conditions of use are critical parameters to take into account when developing a formulation.
Advantages of Gattefossé lubricants:
Gattefossé lubricants are recommended for challenging formulations. They are also able to resolve production and quality issues due to these qualities:
- chemical inertness: no reactive groups and no incompatibility with APIs or other excipients
- robustness: resistant particles of homogeneous size ensure constant surface area; mixing time and speed do not change the quality of the lubrication or tablet properties
- effective lubrication that preserves tablet attributes: hardness, disintegration time, and drug release
The information on the topic of lubrication excipients is taken from the chapter
“Excipients for Lubrication” from the Gattefossé website.
Range of lubricants:
Compritol® 888 ATO for challenging pharmaceutical tablets:
- highly reproducible spherical particles having a mean size of 50 µm
- well-defined, highly reproducible plant-based composition
- recommended for use at proportion of 1%–3% (w/w)
- inertness with no reported incompatibility with APIs
- lubrication unaffected by mixing time and speed
- GRAS status and precedence of use with many APIs (FDA IID)
Compritol® HD 5 ATO for water dispersible tablets:
- highly reproducible spherical particles having a mean size of 50 µm
- well-defined, highly reproducible composition including PEG esters to increase aqueous solubility and dispersion properties
- recommended for use at proportion of 1%–3% (w/w)
- can also be used in orodispersible or effervescent tablets
Precirol® ATO 5 for powder capsule filling;
- highly reproducible spherical particles having a mean size of 50 µm
- well-defined, highly reproducible plant-based composition
- improved powder blend flow due to glidant properties
- recommended for use at proportion 1%–3% (w/w)
- GRAS status and precedence of use with many APIs (FDA IID)
Source: Gattefosse Website chapter “Excipients for Lubrication”