Fast Dissolving Tablets – An Updated Review
Fast dissolving tablets (FDTs) is one of the most widely accepted and popular dosage form, especially for paediatric and geriatric patients. Conventional solid dosage forms like tablets and capsules are facing the problems like difficulty in swallowing (dysphasia), resulting in many incidences of non-compliance.
FDTs have benefits such as accurate dosing, easy portability, and ease of manufacturing; good physical and chemical stability. FDTs are designed in such a way that, they are dissolved rapidly in the saliva less than 60 sec. Direct compression method is preferred among all the other conventional methods of their preparation. Compared to the conventional tablets the amount of drug that is subject to first pass metabolism is reduced, thereby increase the bioavailability of the drug.
Various patented technologies and marketed FDTs are updated in this review. Due to its potential market and advantages, many drugs (e.g. neuroleptics, CVS, analgesics, antihistamines and erectile dysfunction) will be developed as FDTs in the future.
Article Information: Ashok Thulluru, K. Saravanakumar, Ch. S. Phani Kumar, Nawaz Mahammed, D. Sreeja, G. Bhuvanesh, N. Vamsi Chowdary, Nayeema Khowser Shaik; Res. J. Pharma. Dosage Forms and Tech.2019; 11(4):296-303.