Investigating the benefits of delivering gastric resistant functionality to a tablet by applying a colourless top-coat based on Kollicoat® MAE 30 DP
![Cracks in the MAE top-coat, formulation containing 10 % TEC](https://www.pharmaexcipients.com/wp-content/uploads/2020/08/Cracks-in-the-MAE-top-coat-formulation-containing-10-TEC.png)
In the field of gastric resistant film-coating, a lot of obstacles can occur during formulation development. Some pharmaceutical actives (e.g. omeprazole) are prone to interactions with the functional polymer poly(methacrylic acid-co-ethyl acrylate) (MAE). Yet, one should consider that the coating material itself is also vulnerable to interactions with excipients (such as pigments or colourants) present in the coating formulation.
This work was set to investigate whether the gastric resistant functionality can be applied with a colourless film, coated onto a tablet bearing a coloured instant release sub-coat.
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