From lead to investigational new drug

The new e-Guide covers successful preclinical studies with Gattefossé excipients. Gattefossé developed a guideline to help formulate molecules with poor solubility and oral bioavailability into more drug-like compounds. The approaches described will provide effective strategies to obtain the target dose, sufficient to allow the characterization and optimization of the pharmacokinetic, efficacy and safety profile. The aim is to help formulators work with Gattefossés excipients to get the best results possibly reducing the risk of failure later on during development.

See the video here:

Kolliphor® CS 12 and Kolliphor® CS 20 – emulsifiers by BASF

Use of Poly(vinyl alcohol) in Spray-Dried Dispersions: Enhancing Solubility and Stability of Proteolysis Targeting Chimeras

Blend uniformity monitoring in a continuous manufacturing mixing process for a low-dosage formulation using a stream sampler and near infrared spectroscopy

The Guideline covers

Enabling strategies for efficacy, PK and safety evaluation
Safety and tolerability information
Handling and dosing recommendations
Excipient summary tables

Get a copy of the guideline