Kinetically stable propofol emulsions with reduced free drug concentration for intravenous delivery
Purpose
Intravenous injections of propofol emulsions are accompanied by pain likely due to the interaction of the dissolved drug with endothelial cells of the vasculature. It is commonly hypothesized that reducing the aqueous phase concentration of propofol could reduce pain.
http://www.sciencedirect.com/science/article/pii/S0378517315002732