Nanostructured lipid carriers complexed with mesoporous silica nanoparticles in encapsulating lipid-insoluble functional substances or volatile compounds
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Many functional substances are hardly dissolved in water or lipid at ambient temperature, which causes some difficulties in product formulation. Therefore, the aim of this research was to develop a novel carrier system by complexing nanostructured lipid carriers (NLC) with mesoporous silica nanoparticles (MSN), which can be used to dissolve lipid-insoluble functional substances or control the release of volatile compounds. A lipid-insoluble antioxidant (quercetin) and a labile volatile compound (limonene) were used as model compounds incorporated into this system. The performance of antioxidant activity of quercetin (QT) on the lipid photo-oxidation of NLC, and the release rate and stability of limonene during the manufacturing process and photo-oxidation were investigated.
The addition of MSN-QT greatly improved the lipid stability of NLC during photo-oxidation. Both sheltering effect and antioxidant activity of MSN enhanced the performance of the added antioxidant against the photo-oxidation of NLC. The release rate of limonene was markedly reduced, and photo-stability of limonene was enhanced in this NLC-MSN system.
Highlights:
- • A novel carrier system (NLC-MSN) can dissolve volatile or lipid-insoluble functional substances.
- • NLC-MSN with antioxidants greatly improve the oxidative stability of NLC during photo-oxidation.
- • NLC-MSN can minimize the evaporative loss of volatile compounds during homogenization.
- • NLC-MSN can reduce the release rate of volatile compounds and enhance their photostability.
Article Information: Author links open overlay panelTsung-Shi Yang, Tai-Ti Liu, Hung-I. Liu; Sciencedirect, 2019.