Syloid® XDP silica – New Application Note on Solid delivery of PEG drug solubilizers – Whitepaper
Syloid® XDP silica: Carrier for liquid drug solubilizers in solid dosage form.
Materials
Nifedipine was used as model poorly soluble drug. The Syloid® XDP 3050 silica used was from W. R. Grace & Co. All other excipients and chemicals used were Pharma grade and from leading manufacturers. The saturated solution of Lifedipine was prepared in PEG 400. The obtained solution (1.5ml) was adsorbed on 1gm of Syloid® XDP silica in a beaker with simultaneous mixing. On a larger scale, the solution can be sprayed on Syloid® XDP silica to ensure uniform adsorption. The obtained powder was evaluated by dissolution study using USP apparatus II.