Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Experimental Investigation on Efficacy of Eudragit RS 100 Polymer in Prolonging Glibenclamide…
Abstract
Background: The amalgamation of targeted transportation and enhancement of the release profile of the active pharmaceutical ingredient is a contemporary trend in the evolution of oral medicinal products. A renowned method to…
Block copolymer micelles as ocular drug delivery systems
Abstract
Block copolymer micelles, formed by the self-assembly of amphiphilic polymers, address formulation challenges, such as poor drug solubility and permeability. These micelles offer advantages including a smaller size, easier…
QbD-based formulation development of resveratrol nanocrystal incorporated into soluble mesoporous…
Resveratrol (RSV) has powerful antioxidant activities. However, the bioavailability is still limited due to low solubility and transport issues. Nanocrystal technology has been introduced to address these issues; however, the bulky…
Solid self-nanoemulsifying drug delivery systems of nimodipine: development and evaluation
Abstract
Background
This study aimed to formulate solid self-nanoemulsifying drug delivery systems (SNEDDS) for nimodipine (NIM). The selection of Cremophor RH 40, Lipoxol 300, and PEG 400 as oil, surfactant, and co-surfactant was based…
Formulation, optimization, and evaluation of non-propellent foam-based formulation for burn wounds…
Abstract
Burn injuries worldwide pose significant health risks due to frequent microbial infections, which worsen complications and increase mortality rates. The conventional antimicrobial formulations are available in the form of…
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Experience the future of Titanium Dioxide (TiO2) replacement!
Discover bright white films and brilliant colors at reasonable weight gains even on your darkest tablet cores!
Enjoy the freedom of choice when banning TiO2 from your…
Integrating bioaccessibility data from the SurroGUT tiny-TIMsg advanced in vitro gastrointestinal…
This poster was presented at CRS 2024 in Bologna
Introduction
The aim of this study was to develop and implement a PBBM to predict the human PK behavior of an orally administered BCS IV drug (compound X) under fasted conditions. The…
Physico-Mechanical and Tableting Properties of Metronidazole Obtained by Crystallo Co-Agglomeration…
Abstract
Background: Due to its simplicity and cost-effectiveness, direct compression has become the approach most frequently used to create tablet. Nonetheless, the active pharmaceutical ingredient should have acceptable flow and good…
Development of monoclonal antibodies in tablet form: A new approach for local delivery
Abstract
Among the various pharmaceutical forms, tablets offer numerous advantages, like ease of administration, cost-effectiveness in production, and better stability of biomolecules. Beyond these benefits, the tablet form opens up…
Importance of β-cyclodextrin substitution level and type for solubilization and stabilization of…
This poster was presented at CRS 2024 in Bologna
Introduction
Parenteral formulations often contain higher concentrations of excipients than active ingredients. These excipients enhance safety, provide solubility, better stability,…
Inclusion complex of 2-phenylethanol in β-cyclodextrin: preparation, characterization, computational…
In the present research, we employed advanced technologies, developing new investigations aiming to obtain simple and inexpensive molecules to reduce pain sensation. For the first time, the inclusion complex of 2-phenylethanol (2-PE) and…
Design, Optimization, and Characterization of Zolmitriptan Loaded Liposomal Gels for Intranasal…
Zolmitriptan is the primary drug for the treatment of Migraine. However, the bioavailability of the drug is low and requires repetitive administration leading to side effects. Zolmitriptan's bioavailability can be improved by incorporating…
A systematic comparison of four pharmacopoeial methods for measuring powder flowability
Abstract
Powder flow is one of the crucial factors affecting several pharmaceutical manufacturing processes. Problems due to insufficient powder flow reduce production process efficiency and cause suboptimum product quality. The U.S.…
Formulation, In-Vitro and In-Vivo Evaluation of Lamivudine-Loaded Solid Lipid Nanoparticles (SLNs)
Background: The solubility and permeability of drugs could be improved using lipid based drug delivery systems (LBDDS). Drugs are usually classified into four groups according to Biopharmaceutical classification system. Lamivudine is a…
Risk-Based Approach for Defining Retest Dates for Active Pharmaceutical Ingredients and Excipients
Abstract
Drug substances and excipients must be stored in recommended storage conditions and should comply with their specifications during the retest period for their use in the manufacture of drug products. The ICH (International Council…
Optimizing Softgel Fill Formulation: Key Considerations
Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes),…
Preparation of nanoparticle and nanoemulsion formulations containing repaglinide and determination…
Abstract
Repaglinide (RPG) belongs to the class of drugs known as meglitinides and is used for improving and maintaining glycemic control in the treatment of patients with Type 2 diabetes. RPG is a Class II drug (BCS) because of its high…
Quality-by-design-based microemulsion of disulfiram for repurposing in melanoma and breast cancer…
Abstract
Aim: The current study aims to develop and optimize microemulsions (ME) through Quality-by-Design (QbD) approach to improve the aqueous solubility and dissolution of poorly water-soluble drug disulfiram (DSF) for repurposing in…
Exploring the potential of native and modified starch and starch nanocrystals in Pickering…
Abstract
Nanocrystals derived from organic particles, such as starch, can be produced through acid or enzymatic hydrolysis reactions to serve as stabilizers in Pickering emulsions. Starch nanocrystals (SNCs) offer the advantage of…
Investigation of the Electrokinetic Potential of Granules and Optimization of the Pelletization…
Abstract
The preparation of pellets using a high-shear granulator in a rapid single-step is considered a good economic alternative to the extrusion spheronization process. As process parameters and material attributes greatly affect pellet…
Fungal Infections: Effect of Eudragit RL-100 Based Miconazole Film Forming Spray
ABSTRACT
Background: Miconazole nitrate, a BCS class II drug which is used for treatment of fungal infections. To minimize the disadvantages of sticky creams and ointments and their tendency to rub off, an intelligent dosage regimen…
Process analytical technology in Downstream-Processing of Drug Substances – A review
Abstract
Process Analytical Technology (PAT) has revolutionized pharmaceutical manufacturing by providing real-time monitoring and control capabilities throughout the production process. This review paper comprehensively examines the…
Quality Assesment and Stability Studies of Metronidazole Tablets Formulations Obtained via Crystallo…
Abstract
Stability studies are essential for assessing the quality, safety, and efficacy of pharmaceutical products, ensuring they maintain their properties over time. This study aimed to assess the stability of metronidazole tablets…
Design of berberine hydrochloride sustained-release cold sol using hydroxypropyl methyl cellulose…
Abstract
In this study, berberine hydrochloride (Ber) was used as model drug to prepare a sustained-release cold sol using hydroxypropyl methyl cellulose (HPMC) to achieve superior drug dissolution and transdermal absorption effects. For…
SOLBIOTE (TM)- Bringing Sustainable Solutions to Biopharmaceuticals
SOLBIOTE (TM) – Injectable-grade Saccharide Excipients for Biopharmaceuticals
Nagase Viita, the first company in the world to mass produce Trehalose, has launched a new product brand SOLBIOTE (TM). This brand features high-purity,…
Learn and enhance your skills in formulation and tableting thanks to STYL’One Nano
In the rapidly evolving field of pharmaceutical sciences, innovative tools and technologies are essential to advancing research and development. One such innovative instrument is the STYL'One Nano, offered by MEDELPHARM. This compact yet…
Preparation and Evaluation of Berberine-Excipient Complexes in Enhancing the Dissolution Rate of…
Berberine is used in the treatment of metabolic syndrome and its low solubility and very poor oral bioavailability of berberine was one of the primary hurdles for its market approval. This study aimed to improve the solubility and…
Flexible modelling of the dissolution performance of directly compressed tablets
In this study, a compartmental disintegration and dissolution model is proposed for the prediction and evaluation of the dissolution performance of directly compressed tablets. This dissolution model uses three compartments (Bound,…
Impact of Excipients Blending on Sugar-Stabilized Therapeutic Proteins
Abstract
Sugars have long been used as stabilizing excipients for protein-based therapeutics during the development and production process. Incorporating stabilizing agents, such as sucrose and trehalose into dry formulations is a common…
Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review
Abstract
Alginate is a natural polymer with good biocompatible properties and is a potential polymeric material for the sustainable development and replacement of petroleum derivatives. However, the non-spinnability of pure alginate…
Bilayer chitosan-based patches for steroidal drug delivery on the oral mucosa
Abstract
Clobetasol-17-proprionate (CP) is the most potent, highly lipophilic topical corticosteroid, used for the treatment of immune-mediated muco-cutaneous diseases. No commercial preparations are available for oral cavity and galenic…
Hydrophobic deep eutectic solvent (HDES) as oil phase in lipid-based drug formulations
There is increasing pharmaceutical interest in deep eutectic solvents not only as a green alternative to organic solvents in drug manufacturing, but also as liquid formulation for drug delivery. The present work introduces a hydrophobic…
Smart laser Sintering: Deep Learning-Powered powder bed fusion 3D printing in precision medicine
Abstract
Medicines remain ineffective for over 50% of patients due to conventional mass production methods with fixed drug dosages. Three-dimensional (3D) printing, specifically selective laser sintering (SLS), offers a potential solution…
Unlocking the Potential of Softgel Capsules: Types and Formulations
Softgel capsules are a popular choice for delivering a wide range of compounds, from pharmaceuticals to nutritional supplements. Their versatility and efficacy hinge on the type of fill material used. Let's explore the three primary types…