PLGA Nanoparticles Based Mucoadhesive Nasal In Situ Gel for Enhanced Brain Delivery of Topiramate
Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,abdominal pain, and fluctuations in plasma levels. The purpose of this research was to develop an intranasal in situ gel based system comprising Topiramate polymeric nanoparticles and evaluate its potential both in vitro and in vivo. Poly (lactic-co-glycolic…
Lecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human…
In previous studies, lecithin-based nanoemulsions (NEs) have been shown to be skin friendly drug carrier systems. Due to their nontoxic properties, NEs might also be suitable as wound healing agents. Hence, different O/W NEs based on …
Pharma Drama Video: Probiotics for constipation and gut health in children and young people with…
In this video Simon Gaisford, Pharma Drama, explains a research project that he is running in partnership with Down's Syndrome UK, Down's Syndrome Research Foundation UK, 21 Together and a major probiotics manufacturer. The aim is to…
Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line…
The influence of different tableting process parameters on lead-lag was studied by collecting in-line near-infrared (NIR) spectra in the filling chamber of the tablet press feed frame and off-line NIR tablet data. Lead-lag is defined as the…
The impact of quantity of lipid based formulations with different compositions on the oral…
In this study, the effect of the quantity of lipid-based formulations (LBFs) on the oral absorption of ritonavir (RTV), a model for poorly water-soluble drugs, was investigated. Two types of LBFs, comprising short- and medium-chain lipids…
Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded…
Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug…
Development of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor…
Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as…
Impact of Surface Properties of Core Material on the Stability of Hot Melt-Coated Multiparticulate…
Hot melt coating (HMC) of an active pharmaceutical ingredient (API) powder with lipid-based excipients is an innovative method for manufacturing patient-convenient dosage forms. However, drug release instability is still its main industrial…
Are lipid nanoparticles really superior? A holistic proof of concept study
Lipid nanoparticles are a successful carrier system for dermal drug delivery. They possess various beneficial properties, i.e., increased chemical stability for chemically labile compounds, increased dermal penetration of active compounds,…
Lipid Nanoparticles for Drug Delivery
Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the same time, lipid nanoparticles have also demonstrated…
Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion…
The Effect of Capsule-in-Capsule Combinations on In Vivo Disintegration in Human Volunteers: A…
Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules…
Design and optimization of process parameters of polyvinyl alcohol-graft-lactic acid films for…
The objective was to apply a simplex lattice design to determine the properties of polyvinyl alcohol-graft-lactic acid (PVA-g-LA) with different values for two independent variables: curing time (X1) and LA ratio (X2). Each independent…
The polysorbate containing AstraZeneca COVID-19 vaccine is tolerated by polyethylene glycol (PEG)…
Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. We previously demonstrated PEG allergy was a cause of severe anaphylaxis to the Pfizer/BioNTech COVID-19 vaccine. PEG is widely used in many household products,…
Omyanutra® 300 DC – Direct compressible, porous excipient for nutraceuticals
Producing nutraceuticals in solid dosage form is complex and faces many challenges. In production, manufacturers choose either wet or dry granulation, or, which is becoming more popular, direct compression. Direct compression (DC) results…
Comparative evaluation of mechanical properties of lactose-based excipients co-processed with…
The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of co-processed…
Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat…
The purpose of present study was to prepare transdermal therapeutic system that could enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin permeation. Solubility studies screened triacetin as oil,…
Spray layering of human immunoglobulin G: Optimization of formulation and process parameters
Spray layering is a technique used to apply drug or functional polymers onto carrier beads; in addition, it can be used as an alternative method for protein drying and to layer protein on a multiparticulate delivery system. In this study,…
Chitosan hydrogel for topical delivery of ebastine loaded solid lipid nanoparticles for alleviation…
Ebastine, is an antihistamine drug that exerts its effect upon oral administration in humans for the treatment of allergic contact dermatitis (ACD), it also has some systemic side effects like gastric distress, headache, drowsiness, and…
Phase behaviour and characterization of micelles of graft copolymer Soluplus® and non-ionic…
The present study deals with the self-assembly of a pure graft copolymer: Soluplus® and a non-ionic surfactant: Solutol® HS15 and focuses on their clouding behaviour in the presence of different additives viz. inorganic salts (NaF, NaCl,…
Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous…
Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development,…
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a…
Quality by Design applied to the development of soft gelatin capsules
The pandemic we are experiencing made us realize the impact and need for medication in patients' lives. These, in turn, are substances that contain drugs in their composition, the so-called active principles responsible for alleviating…
Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational…
The multi-drug resistance of Pseudomonas aeruginosa is an overwhelming cause of terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy has been shown for colistin and ivacaftor, and our study…
Emerging Theranostic Nanomaterials in Diabetes and Its Complications
Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar…
Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder…
Liquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin were prepared by dissolving them in isotropic mixture of Labrafil M1944CS®, Capmul MCM®, Tween-80® and Transcutol P®. The prepared L-SNEDDS were…
Understanding the Effect of Energy Density and Formulation Factors on the Printability and…
Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy…
Programmable microbial ink for 3D printing of living materials produced from genetically engineered…
Living cells have the capability to synthesize molecular components and precisely assemble them from the nanoscale to build macroscopic living functional architectures under ambient conditions. The emerging field of living materials has…
The Influence of Relative Humidity and Storage Conditions on the Physico-chemical Properties of…
Dry powder inhalers (DPIs) are favorable devices for the delivery of dry formulations to the lungs; still, they largely fail to deliver higher doses of active pharmaceutical ingredient (API) to the lower airways. Addition of fine particles…
Acceptability of different oral dosage forms in paediatric patients in hospital setting
Objective The understanding of acceptability of existing dosage forms is limited in most of the world and hinders the development of acceptable, age‐appropriate medicines. The attributes of paediatric medicine acceptability may differ…
Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component…
An important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric excipients. The excipients can be selected, among others, by compatibility studies since…
Clinical Demonstrations of Controlled-Release Tablets Constructed by the Combined Usage of Shellac…
A new tablet system was examined for an intestinal delivery system using hydroxypropyl methylcellulose (HPMC) and shellac. HPMC was incorporated into the inside of the tablet, and shellac was coated on the surface, which was evaluated for…
Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni…
Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for…
Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher. Microbial drug depletion is often…
Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review
Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused…