World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review
Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused…
Explicating the Applications of Quality by Design Tools in Optimization of Microparticles and…
Quality by design (QbD) can also contribute to design, manufacturing, and producing highly finished goods. To better explain the manufacturing processes, the FDA focused QbD in the healthcare industry, based on a comprehensive understanding…
A novel electronic tongue using electropolymerized molecularly imprinted polymers for the…
The combination of chemometrics and electrochemical sensors modified with molecularly imprinted polymers (MIPs) towards the development of MIP-based electronic tongues (ETs) was explored herein. To demonstrate the potential of such an…
3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery
3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound…
Understanding the Importance of Capsules in Dry Powder Inhalers
Pulmonary drug delivery is currently the focus of research and development because of its potential to produce maximum therapeutic benefit to patients by directing the drug straight to the lung disease site. Among all the available delivery…
The technology of transdermal delivery nanosystems: from design and development to preclinical…
Transdermal administration has gained much attention due to the remarkable advantages such as patient compliance, drug escape from first-pass elimination, favorable pharmacokinetic profile and prolonged release properties. However, the…
Formulation development and evaluation of taste masked anthelmintics chewable tablets by using…
The aim of the current study is to develop and evaluate patient friendly taste masked anthelmintics chewable tablets for pediatrics and geriatrics use. However, the chewable tablets have to disintegrate in the mouth before swallowing, which…
Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for…
Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability.…
Approaches of 3D printing in current drug delivery
Three-dimensional printing (3DP) is predicted to be one of the most progressive innovations within the pharmacy. Nowadays, the use of 3D printing technologies in drug delivery systems has exponentially expanded, due to its potential…
ExciPerience – Overview & explanation of our event around excipients
What is the ExciPerience? - A short summary
ExciPerience is the virtual event around every aspect of pharmaceutical excipients. ExciPerience covers all areas from basic or advanced research and formulation to manufacturing and regulatory.…
Developing mRNA for therapy – Not Warp Speed – Reichstein Award Lecture 2021 by Prof.…
It is the stated goal of SAPhS to promote pharmaceutical sciences and scientists. This includes promoting their perception and recognition among the population. The awarding of the Reichstein Medal should contribute to this. It is…
Nanocrystal-based 3D-printed tablets: Semi-solid extrusion using Melting solidification printing…
This is the first report on the inclusion of nanocrystals (NCs) within 3D-printed oral solid dosage forms – 3D-printed tablets or printlets – produced by the Melting Solidification Printing Process (MESO-PP) 3D printing technique. This…
Characterization of excipients to improve pharmaceutical properties of sirolimus in the…
Enhanced drug release and bioavailability of poorly soluble active pharmaceutical ingredient (API) can be achieved via a fluidized bed coating integrated with supercritical anti-solvent (SAS-FB) – a process of precipitating drug particles…
Binder jetting 3D printing of challenging medicines: from low dose tablets to hydrophobic molecules
Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation…
Part III of the series – Encapsulating cannabinoids in lipid-based nanoparticles: THC vs. CBC
Enhancing cannabinoids’ therapeutic efficacy
In our previous technical note, we reported on the encapsulation of CBD vs THC (1) into lipid-based nanoparticles. The work here-in continues on that theme in terms of studying the differences…
Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-Nanoparticle…
Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the…
Enhancing bioaccessibility and bioavailability of carotenoids using emulsion-based delivery systems
The consumption of foods rich in antioxidants, vitamins, minerals including carotenoids etc. can boost the immune system to help fight off various infections including SARS- CoV 2 and other viruses. Carotenoids have been gaining attention…
Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders
Purpose
Accurate and reliable feeding of small quantities of powder is crucial in many industries. It is particularly true in the case of pharmaceutical manufacturing. First, the exact dosage of highly potent active pharmaceutical…
Optimization study of combined enteric and time-dependent polymethacrylates as a coating for colon…
Formulation design for colon-specific delivery of 5-aminosalicylic acid (5-ASA) could bring some therapeutic benefits in the treatment of ulcerative colitis (UC).
In the current study, a 32 full factorial design was used to predict optimum…
Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed…
Crosslinking is an established treatment to alter the physicochemical and functional properties of polymers through the creation of bonds between the polymer chains. Polymers can be crosslinked via radiation in the presence of…
Towards a Better Understanding of Verapamil Release from Kollicoat SR:IR Coated Pellets Using…
The aim of this study was to gain deeper insight into the mass transport mechanisms controlling drug release from polymer-coated pellets using non-invasive analytical tools. Pellet starter cores loaded with verapamil HCl (10% loading, 45%…
Plant-Derived Saponins: A Review of Their Surfactant Properties and Applications
In response to increasing natural surfactant demand and environmental concerns, natural plant-based surfactants have been replacing synthetic ones. Saponins belong to a class of plant metabolites with surfactant properties that are widely…
Oral insulin delivery by epithelium microenvironment-adaptive nanoparticles
Oral protein drug delivery using nano-based systems remains challenging, as contradictory surface properties are required for efficient navigation through the intestinal mucus and epithelium barriers. Therefore, new nanoplatforms with…
Evaluation of the Disintegrant Properties of Silicified Oryza sativa Starch Co-Processed with…
Starch is a readily available excipient which finds application in the pharmaceutical industry as binders, diluents and disintegrants. The use of starch is however limited by its poor flow characteristics. Co-processing exploits the…
Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA 64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid…
New BENEO webinar: From powder to DC oral solid dosage forms
galenIQ™ is a sweet-tasting water soluble filler binder derived from sugar beet. It is available in several different morphological forms which are suitable for the formulation and manufacture of oral solid dosage forms including tablets,…
VIVACOAT® seal – The Unique Multifunctional Film Coating!
VIVACOAT® seal is a clear Ready-to-Use Coating system based on shellac. It is dedicated for the use on nutritional supplements.
Why is VIVACOAT® seal a multifunctional coating? The performance of VIVACOAT® seal depends on the thickness…
Application of a liquisolid technique to Cannabis sativa extract compacts: Effect of liquid vehicles…
This work describes the application of the liquisolid technique to enhance cannabinoid dissolution from Cannabis sativa L. (CS) compacts. The effects of five vehicles, namely, volatile (ethanol) and nonvolatile (caprylocaproyl…
Omyanutra® 300 Flash – The all-in-one solution for ODTs and FDTs
The world of nutraceutical tablet formulation is complex and many critical values have to be considered during development - like dissolution properties, shelf-life stability, or exposure to environmental challenges (oxygen, light, humidity…
Injectable Liposome Based Supramolecular Hydrogels for the Programmable Release of Multiple Protein…
Directing and manipulating biological functions is at the heart of next-generation biomedical initiatives such as tissue and immuno-engineering. Yet, the ambitious goal of engineering complex biological networks requires the ability to…
A systematic approach for assessing the suitability of enteral feeding tubes for the administration…
Enteral nutrition plays an important role for patients who are unable to properly swallow food. In such patients, enteral feeding tubes are often used, through which food, but often also oral medications, are administered. However, this can…
Integration of 3D Printing Technology in Pharmaceutical Compounding: Progress, Prospects, and…
A significant limitation of current medication development and usage is the reliance on the 'one-size-fits-all' approach. 3D printing technology is an innovative strategy for customizing medication design and preparation. In this review, we…
Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology
The aim of this study was to prepare HY-038 solid dispersions (SDs) with single carrier at high drug loading and then forming a tablet to enhance solubility, dissolution, and bioavailability via spray drying technology. At the same time, we…
New all-in-one tableting solution with filler, binder, disintegrant and lubricant: Kollitab™ DC 87 L
How can Kollitab™ DC 87 L help you?
Superior flowability
High tablet strength at broad compression forces
Fast disintegration
Order Kollitab™ DC 87 L here!
Key benefits
Manufacturing
Enables fast tablet…