World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Development of pH-Sensitive Chitosan-g-poly(acrylamide-co-acrylic acid) Hydrogel for Controlled Drug…
The present study aimed to develop a pH-sensitive chitosan-based hydrogel for controlled delivery of an anti-hepatitis B drug, tenofovir disoproxil fumarate (TDF). Free radical polymerization was utilized to graft acrylamide and acrylic…
Shares of Sigachi listed today at BSE & NSE!
Shares of Sigachi listed today at BSE & NSE with an overwhelming response. This is very special day to Sigachi and they would like to thank all investors, shareholders, stake holders and their team which is their backbone and each and…
In-line particle size measurement based on image analysis in a fully continuous granule…
The present paper serves as a demonstration how an in-line PAT tool can be used for rapid and efficient process development in a fully continuous powder to granule line consisting of an interconnected twin-screw wet granulator, vibrational…
Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain…
Rivastigmine, a reversible cholinesterase inhibitor, is frequently indicated in the management of demented conditions associated with Alzheimer disease. The major hurdle of delivering this drug through the oral route is its poor…
Quantification and characterization of water within drug-eluting beads
This work describes the analysis and characterisation of polyvinylalcohol (PVA)-based hydrogel polymer beads, specifically focussing on the quantitative and qualitative aspects of water within such beads in the absence and presence of three…
Development and in-vitro in-vivo characterization of in-situ gelling sustained-release nevirapine…
Nevirapine is a BCS class-II drug used in the treatment and prevention of HIV/AIDS, specifically HIV-1. This study was aimed to develop and evaluate a novel pH-responsive in-situ gelling sustained-release nevirapine pediatric suspension…
Emulgel Approach to Formulation Development: A Review
Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties,…
Formulation, characterization, optimization and in-vivo evaluation of methazolamide liposomal…
The rationale of this study was to formulate topically effective sustained release ophthalmic Methazolamide (MTA) liposomal in-situ gel. Lipid film hydration method was employed for the preparation of MTA liposomes consisting of lecithin…
How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium…
The aim of our study was to explore the potential value of metallic (Ag, Cu, and Zn) salts, polymer/metallic nanoparticles, and chlorhexidine (CHX) for improving the antimicrobial activity of calcium hydroxide (CH) against E. faecalis and …
Emulsion-electrospun polyvinyl alcohol nanofibers as a solid dispersion system to improve solubility…
We attempted to improve the solubility of poorly water-soluble drugs by preparing drug-loaded polyvinyl alcohol (PVA) nanofibers as a solid dispersion system via emulsion electrospinning. Probucol (PBC), a poorly water-soluble drug, was…
Development and Pharmacokinetic Evaluation of a Self-Nanoemulsifying Drug Delivery System for the…
The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased in recent years. These drugs often possess physicochemical properties that result in poor oral bioavailability, and their clinical potential may be…
Design, Development, and Characterization of Amorphous Rosuvastatin Calcium Tablets
This work proposes a methodology for the design, development, optimisation, and evaluation of amorphous rosuvastatin calcium tablets (BCS class II drug). The main goal was to ensure rapid disintegration and high dissolution rate of the…
Enhanced Supersaturation via Fusion-Assisted Amorphization during FDM 3D Printing of Crystalline…
Filaments loaded with griseofulvin (GF), a model poorly water-soluble drug, were prepared and used for 3D printing via fused deposition modeling (FDM). GF was selected due to its high melting temperature, enabling lower temperature hot-melt…
Impressions of the Excipients Hall at CPhI 2021
Today is the last day of the CPhI worldwide in Milan 2021. We want to show you the general look and feel with a few walkthroughs and photos.Walkthrough Excipients Hall 7 at CPhI 2021 in Milan
:Walkthrough Hall P-Mec at CPhI 2021 in…
On the Feasibility of Spray-Dried Eudragit-Trehalose Microparticles for Enteric Drug Delivery
Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year. Because of the global rise in antibiotic-resistant bacteria and the slow development of new…
Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1…
Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR plasmids discovered in 2015 have now been reported worldwide in humans. To keep this…
Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and…
Genistein (GT) is a poorly water-soluble flavonoid and reported for different biological activity. The present work was designed to prepare the inclusion complex using β-Cyclodextrins (β-CDs) as complexing agent and D -α-Tocopherol…
An Improved 2-Step Process for Moisture Sensitive Drugs Using Syloid® FP Silicas
Introduction: Several APIs are sensitive to moisture, and formulating these drugs into stable oral dosage forms can pose quite a challenge to formulators. There are several potential problems associated with moisture sensitive drugs, such…
Using Residence time distribution in pharmaceutical solid dose manufacturing – a critical review
While continuous manufacturing (CM) of pharmaceutical solid-based drug products has been shown to be advantageous for improving the product quality and process efficiency in alignment with FDA’s support of the quality-by-design paradigm…
Development and characterization of multiparticulate system as an alternative to unit dosage forms…
Background
Currently, the Bilayer tablets, Tablet in tablet and Inlay tablets composed of Glimepiride (GMP) and Pioglitazone (PGH) as immediate release part, and Metformin (MFH) as sustained-release part are available for the treatment of…
Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release
Data-enriched edible pharmaceuticals (DEEP) is an approach to obtain personalized medicine, in terms of flexible and precise drug doses, while at the same time containing data, embedded in quick response (QR) codes at a single dosage unit…
Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum…
The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder…
Effect of binder type and lubrication method on the binder efficacy for direct compression
The effect of different binders for direct compression on tablet critical quality attributes was investigated. Dicalcium phosphate, lactose and microcrystalline cellulose were used as fillers and combined with ten binders (10, 20 and 30%…
Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl…
Highlights
• The mechanical and rheological properties are limiting steps for FFF.
• Increasing the VA content showed lower buckling stress, elastic and flexural modulus.
• The inadequate flow during FFF was due to the…
Lipid-microparticles for pulmonary delivery of active pharmaceutical ingredients: Impact of lipid…
Spray-drying is an extensively used technology for engineering inhalable particles. Important technical hurdles are however experienced when lipid-based excipients (LBEs) are spray-dried. Stickiness, extensive wall deposition, or simply…
See the new organic certified tableting premix from Biogrund – CompactCel® FLO Organic.
CompactCel FLO Organic helps to ensure a stable and consistent powder flow during the tableting and capsule filling process. Plus it reduces the interparticle friction.
CompactCel® FLO is a flow agent for loosening powder mixtures and…
Sustained-release capsules coated via thermoforming techniques
Capsule coatings have a wide range of applications as they afford protection to active pharmaceutical ingredients. However, few studies have focused on capsule coating owing to the sensitivity of hard gelatin shells to solvents and high…
Regulation of the Use of Pharmaceutical Excipients in India
Excipients are inactive substances formulated along with the active pharmaceutical ingredient(s) (APIs) of medication for bulking up of formulations or to give a therapeutic enhancement of API in the final dosage form. Almost of all the…
Have a look at this years World Diabetes Day!
On the 14th of November is the annual World Diabetes Day.
This year’s theme is “Access to Diabetes Care“. Millions of people with diabetes around the world do not have access to diabetes care. People with diabetes require ongoing care…
Development of a Scalable Process of Film-Coated bi-Layer Tablet Containing Sustained-Release…
The development of new drugs that combine active ingredients for the treatment hypertension is critically essential owing to its offering advantages for both patients and manufacturers. In this study, for the first time, detailed…
Pseudo-3D Subsurface Imaging of Pharmaceutical Solid Dosage Forms Using Micro-spatially Offset…
A new combinatory Raman subtechnique of low-frequency and micro-spatially offset Raman spectroscopy (denoted micro-SOLFRS) is demonstrated via analysis of pharmaceutical solid dosage forms. A variety of different (multilayer/multicomponent)…
Acceptability of small-sized oblong tablets in comparison to syrup and mini-tablets in infants and…
Objective
There is limited evidence for the acceptability of various drug formulations holding the potential to improve medicines administration to children. Suitable formulations need to meet the requirements of pediatric patients.…
Impact of Formulation on the Quality and Stability of Freeze-dried Nanoparticles
Freeze-drying is an effective approach to improve the long-term stability of nanomedicines. Lyoprotectants are generally considered as requisite excipients to ensure that the quality of nanoparticles is maintained throughout the…
Development of Fully Redispersible Dried Nanocrystals by Using Sucrose Laurate as Stabilizer for…
There is much interest in converting poorly water-soluble drugs into nanocrystals as they provide extremely high surface area that increases dissolution rate and oral bioavailability. However, nanocrystals are prepared as aqueous…