World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing…
To relief the severe economic and social burdens and patient suffering caused by the increasing incidence of chronic wounds, more effective treatments are urgently needed. In this study, we focused on developing a novel sprayable wound…
Towards next-generation personalization of tacrolimus treatment: a review on advanced diagnostic and…
The benefit of personalized medicine is that it allows the customization of drug therapy – maximizing efficacy while avoiding side effects. Genetic polymorphisms are one of the major contributors to interindividual variability. Currently,…
In situ solvent removal-based Eudragit®L/dimethyl sulfoxide forming gel for periodontal pocket drug…
Periodontitis is a chronic inflammatory disease of gum resulting from Porphyromonas gingivalis infectious at periodontal pockets. In situ forming gel (ISG) effectively delivers the antimicrobial agents to this targeted site. This study was…
Your visit at CPhI worldwide in Milan
CPhI worldwide opens its real doors again after one year of digital trade show! This year in Milan at the Fiera Milano. Next week, from 9th to 11th November, you can finally have a face-to-face chat with visitors and exhibitors again. As…
Development of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization,…
Hypertension is a cardiovascular disease that needs long-term medication. Oral delivery is the most common route for the administration of drugs. The present research is to develop piperine self-nanoemulsifying drug delivery system…
The evaluation of the effect of different superdisintegrants on the drug release from FDM 3D printed…
Paracetamol-loaded tablets were printed by fused deposition modelling technique, using polyvinyl alcohol as a backbone polymer and Affinisol™ HPMC as a plasticizer in all formulations. Four different strategies were applied in order to…
Pharmatrans excipients for improved compactibility and flowability in tablet manufacture
Pharmatrans SANAQ AG specializes in pharmaceutical excipients and active ingredients, harnessing a spirit of innovation and commitment to high quality products based on a solid platform of experience established over almost four decades.…
Optimization and Scale-up Methodology in Preparing Microsponge Loaded with 5-Fluorouracil (5-FU).
The present investigation aims at developing models by response surface methodology (FCCCD) followed by the scale-up method in preparing control release microsponge particles loaded with 5- fluorouracil, a drug used to treat actinic…
Let’s talk about sex: Differences in drug therapy in males and females
Professor Henry Higgins in My Fair Lady said, ‘Why can’t a woman be more like a man?’ Perhaps unintended, such narration extends to the reality of current drug development. A clear sex-gap exists in pharmaceutical research spanning from…
Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle…
3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin.…
Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment
The incorporation of siRNA into nanocarriers is mandatory to facilitate its intracellular delivery, as siRNA itself cannot enter cells. However, the incorporation of these nanocarriers into oral, solid dosage forms and their fate in the…
Impact of co-administered stabilizers on the biopharmaceutical performance of regorafenib amorphous…
Poor solubility of drug candidates is a well-known and thoroughly studied challenge in the development of oral dosage forms. One important approach to tackle this challenge is the formulation as an amorphous solid dispersion (ASD). To reach…
A synthetic antibiotic class overcoming bacterial multidrug resistance
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern1. For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of…
QbD steered fabrication of Pullulan-Terminalia catappa-Carbopol®971P film forming gel for improved…
In present work, a film forming gel (FFG) was developed through ingenious amalgamation of polymers: Pullulan, Terminalia catappa and Carbopol®971P ® for cutaneous delivery of clotrimazole (CTZ) employing D-optimal mixture design. The…
Monosaccharide-induced growth and higher order transitions in TPGS micelles
D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a nonionic surfactant with low critical micelle concentration. It usually forms spherical core-shell micelles in aqueous media. In this work, we show that these spherical…
In Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System…
Aprepitant (APR) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its low aqueous solubility. The objective of the current work is to develop self-nanoemulsifying drug delivery systems (SNEDDS) of APR to…
Population pharmacokinetics of a posaconazole tablet formulation in transplant adult allogeneic stem…
Posaconazole is an antifungal agent extensively used as a prophylaxis for invasive fungal infections (IFIs) in allogeneic stem cell transplant (SCT) recipients. Low posaconazole concentrations have been associated with reduced clinical…
Lamination of pharmaceutical tablets: classification and influence of process parameters
Lamination is a common industrial problem during the production of pharmaceutical tablets. It corresponds to a failure of the tablet in one or several planes parallel to the surface and passing through the tablet band. But different kinds…
Exploration of theoretical and practical evaluation on Kollidon®SR matrix mediated amorphous…
The selection of an appropriate polymer for the preparation of amorphous solid dispersions via hot-melt extrusion (HME) deals with the study of various solid-state properties of drugs and polymers. Hence, before going to HME, it is…
A comparison of emulsifiers for the formation of oil-in-water emulsions: stability of the emulsions…
Objective
To provide a basis for the selection of suitable emulsifiers in oil-in-water emulsions used as tissue analogs for MRI experiments. Three different emulsifiers were investigated with regard to their ability to stabilize…
Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity
Vaccination is an essential public health measure for infectious disease prevention. The exposure of the immune system to vaccine formulations with the appropriate kinetics is critical for inducing protective immunity. In this work, faceted…
Synthesis of Eudragit® L100-coated chitosan-based nanoparticles for oral enoxaparin delivery
Enoxaparin is an effective biological molecule for prevention and treatment of coagulation disorders. However, it is poorly absorbed in the gastrointestinal tract. In this study, we developed an Eudragit® L100 coated chitosan core shell…
Development of Self-Microemulsifying Drug Delivery System to Improve Nisoldipine Bioavailability:…
The authors attempted to fabricate a novel lipid-based formulation of a lipophilic drug, nisoldipine (NISO). As NISO belongs to BCS class 2 drug, it suffers from low bioavailability (5%). Hence, the research was intended to ameliorate oral…
Photo-triggerable liposomes based on lipid-porphyrin conjugate and cholesterol combination:…
Lipid-porphyrin conjugates are considered nowadays as promising building blocks for the conception of drug delivery systems with multifunctional properties such as photothermal therapy (PTT), photodynamic therapy (PDT), phototriggerable…
Polysaccharide/mesoporous silica nanoparticle-based drug delivery systems: A review
Mesoporous silica nanoparticles (MSNs) have been well-researched in the design and fabrication of advanced drug delivery systems (DDSs) due to their advantages such as good biocompatibility, large specific surface area and pore volume for…
Combination of lipid nanoparticles and iontophoresis for enhanced lopinavir skin permeation: Impact…
Nanostructured lipid carriers (NLC)-loaded with lopinavir (LPV) were developed for its iontophoretic transdermal delivery. Electronic paramagnetic resonance (EPR) spectroscopy of fatty acid spin labels and differential scanning calorimetry …
Development of buccal film formulations and their mucoadhesive performance in biomimetic models
When developing buccal films for oromucosal drug administration, adhesion is essential to ensure sufficient time for permeation of the active ingredient(s) through the oral mucosa and avoid the detachment and subsequent swallowing of the…
Therapeutic efficacy and gastrointestinal biodistribution of polycationic nanoparticles for oral…
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world and is the second leading cause of cancer related deaths. New cases are increasingly diagnosed every day, but current therapeutic options are still…
Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated…
This study describes the preparation and evaluation of two formulations, a hydrogel and a nanostructured system, containing ketorolac tromethamine as an anti-inflammatory agent for the local therapy against the inflammatory process derived…
Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of…
The solution behavior and membrane transport of multidrug formulations were herein investigated in a biorelevant medium simulating fasted conditions. Amorphous multidrug formulations were prepared by the solvent evaporation method.…
Tableted hydrophilic electrospun nanofibers to promote meloxicam dissolution rate
This study investigated the ability of hydrophilic electrospun nanofibers to enhance the dissolution rate of poorly soluble drug Meloxicam (MLX). The drug was loaded into polyvinylpyrrolidone (PVP), polyvinyl caprolactam–polyvinyl…
White Paper: Refined Sesame Oil IV-1
SIO Presentation
ADM-SIO, is a global manufacturer of injectable-grade pharmaceutical oils - used as API’s or excipients for oil-soluble drugs. We offer an extensive range of highly purified oils, derived from vegetable origins that meet…
Development of curcumin and docetaxel co-loaded actively targeted PLGA nanoparticles to overcome…
The aims of this study were to develop and characterize curcumin (CCM) and docetaxel (DTX) co-loaded poly lactide-co-glycolide (PLGA) nanoparticles (NPs) to overcome blood brain barrier. The cytotoxicity of the obtained curcumin and…
Development and characterization of Novel topical oil/PEG creams of voriconazole for the treatment…
Voriconazole (VRC), a second generation triazole derivative emerged as a promising candidate for the treatment of fungal infections. Voriconazole is commercially available as oral and intravenous formulations, however administration through…