Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems. For each formulation ingredient, expert…
Stability, pharmacokinetics, and biodistribution in mice of the EPAC1 inhibitor (R)-CE3F4 entrapped…
(R)-CE3F4, a specific inhibitor of EPAC1 (exchange protein directly activated by cAMP type 1), has been demonstrated in vitro and in vivo to reduce hypertrophic signaling contributing to heart failure or to control arrhythmia and has shown…
Experimental evaluation of protection and immunogenicity of Streptococcus suis bacterin-based…
Streptococcus suis is an important swine pathogen responsible for economic losses to the swine industry worldwide. There is no effective commercial vaccine against S. suis. The use of autogenous (“bacterin”) vaccines to control S. suis …
Formulation, Optimization and Evaluation of Luteolin-Loaded Topical Nanoparticulate Delivery System…
In the present study, luteolin (LT)-loaded nanosized vesicles (LT-NVs) were prepared by a solvent evaporation–hydration method using phospholipid and edge activator. The formulation was optimized using three factors at a three-level…
Oral colon delivery platform based on a novel combination approach: Design concept and preliminary…
An oral colon delivery platform based on a novel combination strategy, leveraging multiple physiological characteristics of the intestine, is proposed. The system comprises a drug core, a water-swellable/soluble inner layer based on a…
Efficient Development of Sorafenib Tablets with Improved Oral Bioavailability Enabled by…
An amorphous solid dispersion (ASD) of sorafenib (SOR) in hydroxypropyl methylcellulose acetate succinate (HPMC-AS), prepared by coprecipitation, was used to develop an immediate release tablet with improved oral bioavailability. An ASD of…
Smartphone-enabled 3D printing of medicines
3D printing is a manufacturing technique that is transforming numerous industrial sectors. Within healthcare, it is empowering the small-scale development of personalised medicines that meet the individual needs of patients. 3D printing…
Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications
Cellulose, the most abundant natural polymer, is a versatile polysaccharide that is being exploited to manufacture innovative blends, composites, and hybrid materials in the form of membranes, films, coatings, hydrogels, and foams, as well…
A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions
A total of 378 novel drugs and 27 biosimilars approved by the U.S. Food and Drug Administration (FDA) between 2010 and 2019 were evaluated according to approval numbers by year, therapeutic areas, modalities, route of administration,…
Manufacturing and Examination of Vaginal Drug Delivery System by FDM 3D Printing
Vaginal drug delivery systems can provide a long-term and constant liberation of the active pharmaceutical ingredient even for months. For our experiment, FDM 3D printing was used to manufacture the vaginal ring samples from thermoplastic…
A Critical Overview of FDA and EMA Statistical Methods to Compare In Vitro Drug Dissolution Profiles…
A drug dissolution profile is one of the most critical dosage form characteristics with immediate and controlled drug release. Comparing the dissolution profiles of different pharmaceutical products plays a key role before starting the…
Interspecies differences in gastrointestinal physiology affecting the in vivo performance of oral…
Various physiological factors in the gastrointestinal (GI) tract affect the in vivo performance of orally administered dosage forms. In this review article, we summarize the formulation-related interspecies differences (particularly under…
Enteric-coated bacteriophage tablets for oral administration against gastrointestinal infections
Intestinal Pseudomonas aeruginosa is highly problematic in immunocompromised patients such as those in intensive care units in hospitals. Phage therapy is an attractive alternative or supplementary therapy to antibiotics as it not only…
Effects of the controlled temperature in the production of high-shear granulated protein-containing…
During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, and during high-shear granulation the impeller and chopper speeds can induce elevated temperatures and…
Development of a 3D-Printed Dosing Platform to Aid in Zolpidem Withdrawal Therapy
The long-term use of benzodiazepine receptor agonists (BZRAs) is associated with multiple side effects, such as increased sedation, hangover or an elevated risk of dependency and abuse. Unfortunately, the long-term use of BZRAs is reaching…
The right spray-dried lactose product for direct compression
Spray-drying (SD) opened the door for lactose in Direct Compression (DC) and had a major impact on tableting technology. After initial quality problems, SD lactose has become a very frequently used, robust excipient grade in pharmaceutical…
UNGAP best practice for improving solubility data quality of orally administered drugs
An important goal of the European Cooperation in Science and Technology (COST) Action UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www.ungap.eu) is to improve standardization of methods relating to the study of oral…
Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using…
Purpose: This study aimed to formulate an orally disintegrating tablet (ODT) containing both baclofen and meloxicam together for treating osteoarthritis.
Methods: Direct compression method was used to prepare ODTs using three types of…
Dry Powder Mixing Is Feasible in Continuous Twin Screw Extruder: Towards Lean Extrusion Process for…
Using discrete element method (DEM) modeling and near-infrared (NIR) spectroscopy, the feasibility of powder mixing in the initial pre-melting zones of a twin screw extruder using two independent feeders was studied. Previous work in the…
Downstream processing of spray-dried ASD with hypromellose acetate succinate – Roller compaction and…
Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-dried amorphous solid dispersion (ASD) drug products, little information is available in the references on downstream processing of spray-dried…
Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to…
One of the most striking characteristics of 3D printing is its capability to produce multi-material objects with complex geometry. In pharmaceutics this translates to the possibility of dosage forms with multi-drug loading, tailored dosing…
How to Tame Recalcitrant Ingredients with Technological Processes
Among the currently trending functional ingredients, interest in natural sources such as turmeric and its polyphenol, curcumin, has been increasing for years. The spice is not only in demand in the culinary world, but has also found great…
Amorphous Solid Dispersions (ASDs): The Influence of Material Properties, Manufacturing Processes…
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral absorption leading to poor bioavailability. Several approaches exist that improve the oral absorption of such compounds by enhancing the aqueous…
Pharmaceutical oils for Cannabinoid drug products from ADM-SIO
Medicinal Cannabinoids
There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy…
Surface energy considerations in ternary powder blends for inhalation
The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery. Well-established formulations like carrier-based blends still show a lack of efficiency. The addition of extrinsic fine excipients is…
Impact of solvents during wet stirred media milling of cross-linked biopolymer suspensions
The aim of this study was to examine the impact of solvents during the wet stirred media milling of cross-linked biopolymers considering breakage kinetics, physical stability of the suspensions, and microhydrodynamics. To this end, a model…
F-CAD Cloud brings formulation design to your desktop
F-CAD Cloud is a web software platform for in silico pharmaceutical formulation design based on the latest GPU-powered massively parallel computing paradigm. F-CAD Cloud reduces the laboratory work needed to design a new solid dosage…
Overcoming challenges in effervescent dosage manufacturing
Easy to use and with improved technical properties, BENEO’s galenIQ™ 721 filler-binder optimizes the production of fizzy tablets and powders
To improve the taste and stability of effervescent tablets and powders, BENEO presents galenIQ™…
Supramolecular Organization of Polymer Prodrug Nanoparticles Revealed by Coarse-Grained Simulations
Drug–polymer conjugates that can self-assemble into nanoparticles are promising drug delivery systems that improve the drug bioavailability and allow their controlled release. However, despite the possibility of reaching high drug loadings,…
Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled…
Polycarbophil (POL), a polyacrylic acid cross-linked with divinyl glycol, is widely used in semisolid and solid dosage forms. When undergoing a thermal treatment in the range 120–160 °C, POL shows interesting morphological modifications,…
Gelucire® 59/14, solid surfactant for oral bioavailability enhancement
Gattefossé widens its range of functional excipients for oral bioavailability enhancement with a new grade of Gelucire®: Gelucire® 59/14, a mixture of lauroyl PEG-32 glycerides EP/NF and PEG 6000 EP/NF.
Gelucire® 59/14 is a…
Oil adsorption – The Interview with Fuji Chemical
Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. They spray-dry their excipients to produce free-flowing granules and unique internal structures that enhance…
Hepatoprotective, antioxidant and anti-inflammatory potentials of Vit-E/C@SeNPs in rats: Synthesis,…
This study aimed to synthesize a nano-structure between selenium, Vit. C, and Vit. E (Vit-E/C@SeNPs) as a promising protective and therapeutic agent for hepatocellular carcinoma. Vit-E/C@SeNPs were characterized using TEM and DLS and its…
Development of Mucoadhesive Film-Forming Systems Containing Black Ginger Extract for Aphthous Ulcers
Film-forming systems (FFSs) were developed by using Eudragit® E100 as a film former. Kaempferia parviflora (black ginger) extract was used as an anti-inflammatory agent for aphthous ulcers. The FFS could rapidly form a thin film in only 5 s…
DEVICE DEVELOPMENT – Selecting Drug Delivery Systems for Higher Doses, Higher Viscosities &…
The development of new parenteral biologics with high-volume, high-viscosity formulations (> 1 mL, >15 cP) is triggering the need for devices that can deliver these therapies with the ease, safety, and low injection time required for…