World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Viscosity Reduction Platform by Merck
Carrying out intended dosing regimens often require highly concentrated protein formulations that may be too viscous for subcutaneous administration or other routes of administration that are limited by volume. While reducing…
In vivo evaluation of a novel zero order drug releasing transdermal system of rotigotine
Background: Rotigotine is a new non-ergolinic dopamine agonist used in the treatment of Parkinson's disorder and restless legs syndrome. It has extensive pre-systemic metabolism and administration of rotigotine through transdermal route is…
Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds
Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility,…
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation…
Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through…
Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral…
There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery…
Preparation and Characterization of Ibrutinib Amorphous Solid Dispersions: a Discussion of…
The aim of this study was to improve the solubility and dissolution of Ibrutinib (IBR), a biopharmaceutical classification system (BCS) class II drug, by preparing binary and ternary amorphous solid dispersions (ASDs). The physicochemical…
Impressions from Vitafoods 2021
The time has come! The first live events are starting again, including Vitafoods in Geneva. Unlike usual, Vitafoods is a hybrid event. Participants can decide if they want to participate online only or visit the halls in Geneva as well.…
Phospholipids – Nature’s Versatile All-Rounders Showing Excellent Tolerability
Phospholipids (PLs) are essential building blocks of all biological membranes exhibiting a huge variety of functions. They play an essential role in the natural digestive process of food and are excreted as component of bile by the liver.…
Lipopolysaccharide Nanosystems for the Enhancement of Oral Bioavailability
Nanosystems that incorporate both polymers and lipids have garnered attention as emerging nanotechnology approach for oral drug delivery. These hybrid systems leverage on the combined properties of polymeric and lipid-based nanocarriers…
Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms
A variety of dosage forms have been developed in order to achieve effective and safe drug delivery in topical or systemic drug administrations. In this review, formulation research and process issues related to a popular oral dosage form,…
Role of Permeability on the Biopredictive Dissolution of Amorphous Solid Dispersions
An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect physicochemical, physiological, and hydrodynamic conditions which accurately represent in vivo dissolution. However, this is confounded by the evolution of…
Crystalline material: Definition and explanation by Pharma Drama
In this video Pharma Drama looks at the basic definition of a crystalline material - how they are defined, what unit cells and polymorphs are, and why they have different physical properties.
Watch the video here:…
Development of a technology for producing a stable injectable dosage form of a hydrophobic…
Objective: Development of a technology for production of a stable injectable dosage form (IDF) of indolocarbazole derivative LHS-1269.
Methods: LHS-1269 is an active pharmaceutical ingredient that was synthesized in the N.N. Blokhin…
The interactions in ternary system made of xanthan gum, Carbopol 940 and anionic/nonionic surfactant
The development and optimization of systems consist of polymers and surfactants are strongly related to the presence of interactions between them. Therefore, the interpolymer complexes between biopolymer xanthan gum and synthetic polymer…
Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies
In the field of oncology, a lot of improvements in nanotechnology creates support for better diagnosis and therapeutic opportunities, and due to their physical and chemical properties, gold nanoparticles are highly applicable. We performed…
Effervescent formulations with galenIQ™
Many patients and consumers have difficulty to swallow standard-sized tablets. For these persons, a more convenient form is to provide the medicine or supplement as an effervescent tablet or effervescent powder!
A non-hygroscopic…
Web-Seminar series: Advances In Amorphous Solid Dispersion Technologies: Downstream Processing
In this series of webinars we will discuss the latest developments in the fields of amorphous solid dispersion (ASD) focusing on Excipient Key Attributes linked to the most popular technologies: Hot Melt Extrusion (HME), Spray Drying and…
Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case…
Fuse deposition modelling (FDM) has emerged as a novel technology for manufacturing 3D printed medicines. However, it is a two-step process requiring the fabrication of filaments using a hot melt extruder with suitable properties prior to…
Cyclodextrins-modified metallic nanoparticles for effective cancer therapy
Cancer, a disease of unknown origin is the second most common reason of death worldwide after heart attacks and therefore is a major threat to human beings. Currently, chemotherapy is the only approach for delivering anti-cancer drugs but…
Novel graphene oxide loaded sodium alginate hydrogels cross-linked with tetraethyl orthosilicate for…
In this work, novel graphene oxide (GO) loaded (0–40 mg), sodium alginate (Na-Alg) hydrogels were prepared using tetraethyl orthosilicate (TEOS) as a silane cross-linker and then characterized by FTIR and XRD analysis, TGA and SEM analysis,…
Strategies for the delivery of antidiabetic drugs via intranasal route
Diabetes is a metabolic disorder defined by higher blood glucose levels in the body generally controlled by antidiabetic agents (oral) and insulin (subcutaneous). To avoid the limitations of the conventional routes such as lower…
Big family of nano- and microscale drug delivery systems ranging from inorganic materials to…
Traditional drug administration routs suffer from low selective distribution, poor solubility, fast elimination and damaging adjacent healthy tissues (especially in cancer therapy). Thus, drug delivery systems (DDSs) which could deliver…
Self-assembled tacrolimus-loaded lecithin-chitosan hybrid nanoparticles for in vivo management of…
Lecithin-chitosan hybrid nanoparticles are emerging as a promising nanocarrier for topical drug delivery. They could achieve a maximized encapsulation of hydrophobic drugs due to the lipophilic nature of lecithin that comprises the core…
Nanocarriers for oral delivery of biologics: small carriers for big payloads
Biologics have gained immense popularity in the past two decades as new and personalized medicines. Yet, the majority of the approved biologics are administered via the parenteral route (i.e., via injections).
Biologics therapy is…
Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of…
Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine. However, their potential in the field of drug delivery was not yet explored. We thus prepared lauroyl hyaluronan films…
Physiologically relevant model to establish the in vivo-in vitro correlation for etamsylate…
Background
In vivo-in vitro correlation (IVIVC) are used during product development for optimization of drug formulations and can serve as a surrogate for bioequivalence studies.
Aim
This research was performed to investigate the…
The Effect of PVP Viscosity on the Binding Performance in Naproxen Tablets
Certain active ingredients can present flow and compactability challenges, requiring wet granulation to enable high-speed tableting. This study aimed to compare the performance of VIVAPHARM® PVP K25, VIVAPHARM® PVP K30, and VIVAPHARM® PVP…
Digital Twin of Low Dosage Continuous Powder Blending – Artificial Neural Networks and…
In this paper we present a thorough description of the digital twin development for a continuous pharmaceutical powder blending process in accordance with the Process Analytical Technologies (PAT) and Quality by Design (QbD) guidelines. A…
Encapsulating cannabinoids in lipid-based nanoparticles: THC vs. CBD – Part 2 of the series
Enhancing cannabinoids’ therapeutic efficacy
In our previous technical note, we reported on the encapsulation of CBD vs CBDA (1). The work here-in continues on that theme in terms of studying the differences in encapsulating different…
Enhance the solubility of poorly soluble drugs with AFFINISOL™
Looking to enhance the solubility of poorly soluble drugs?
Consider AFFINISOL™, a water-soluble polymer that optimizes solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
It’s been…
RespiCellTM: An Innovative Dissolution Apparatus for Inhaled Products
To overcome some of the shortfalls of the types of dissolution testing currently used for pulmonary products, a new custom-built dissolution apparatus has been developed. For inhalation products, the main in vitro characterisation required…
Road map to the treatment of neglected tropical diseases: Nanocarriers interventions
Neglected tropical disease (NTD) is a set of 20 deadliest endemic diseases which shows its presence in most of the developing countries worldwide. Nearly 1 billion of the population are affected by it and suffered from poverty yearly. These…
Deformation potential and tensile strength of tablets of a dry granulated formulation
The increase in solid fraction (SF) of a packed granule bed with pressure applied during the in-die compression process results in an evolution of the tablet's matrix and mechanical strength. In this case study, the tensile strength (TS) of…
Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based…
Betulinic acid (3β-Hydroxy-20(29)-lupaene-28-oic acid, BA) has excellent anti-cancer activity but poor solubility and low bioavailability. To improve the antitumor activity of BA, a polyvinyl caprolactam–polyvinyl acetate–polyethylene…