World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Nano Spray-Dried Drugs for Oral Administration: A Review
Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional…
INSTACOAT 4G: Innovative tablet coating formulation
INSTACOATTM 4G is a ready-mixed powder that can be rapidly reconstituted in water, for the film coating of solid oral dosage forms. It contains polymer, plasticizer, pigments, etc. in optimal ratios to achieve significant benefits in terms…
Amorphous material: Definition and explanation by Pharma Drama
In this video Pharma Drama looks at the basic definition of an amorphous material - how they are defined, why they should really be considered as viscous liquids, and why they have different physical properties from crystalline materials.…
Analysis of Endoscopic Injectability and Post-Ejection Dripping of Yield Stress Fluids: Laponite,…
Yield stress fluids, which show reversible gel–sol transition and a decrease in viscosity via shear, are expected for endoscopic applications. However, quantitative analyses of such fluids, including pressure drop during endoscopic catheter…
Thin-film freeze-drying of a bivalent Norovirus vaccine while maintaining the potency of both…
A bivalent Norovirus vaccine candidate has been developed that contains Norovirus strain GI.1 Norwalk-virus like particles (VLP) and strain GII.4 Consensus VLPadsorbed on aluminum (oxy)hydroxide. The Norwalk and Consensus antigens have…
Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing…
One of the challenges for developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating…
Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification…
Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum…
Application of commercially available mesoporous silica for drug dissolution enhancement in oral…
Due to the high number of poorly water-soluble active pharmaceutical ingredients, oral drug delivery development has become challenging. One of the strategies to enhance drug solubility and to achieve high oral bioavailability is to…
Chitosan-encapsulated niosomes for enhanced oral delivery of atorvastatin
Atorvastatin is the most commonly used hypolipidemic drug. It provides excellent protection against cardiovascular disease especially in subjects having high risk factors. However, atorvastatin has problematic biopharmaceutical…
Orodispersible films: Conception to quality by design
Orodispersible films (ODFs) are pharmaceutical dosage forms that do not need water to be ingested. Perfect for paediatrics and geriatrics
Recent trends in nanocarrier based approach in the management of dry eye disease
Dry eye disease (DED) represents a major public health issue worldwide. Conventional ophthalmic preparations usually have a short pre-corneal residence time, require frequent and prolonged administration of drugs, lead to poor medication…
Quantitative characterisation of extended release tablets with quetiapine using NIR chemometric…
This study aims to develop and validate NIR-chemometric methods for quantifying the API (quetiapine) and two excipients in extended-release tablets without sample preparation. The calibration samples were prepared following an experimental…
Suspensions and Solutions by IFF Pharma Solutions
Improving patient experience and compliance
Better drug design and delivery options can help improve the likelihood that patients will be more willing to take their medications as prescribed.
Suspensions are defined as finely divided…
Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering…
Oral delivery of peptides is a challenge due to their instability and their limited transport and absorption characteristics within the gastrointestinal tract. In this work, we used layering techniques in a fluidized bed dryer to create a…
Sensing technologies and experimental platforms for the characterization of advanced oral drug…
Complex and miniaturized oral drug delivery systems are being developed rapidly for targeted, controlled drug release and improved bioavailability. Standard analytical techniques are widely used to characterize i) drug carrier and active…
Study of solid-state transitions and its impact on solubility and stability of Repaglinide
The aim of this research was to study the impact of melting and quenching approach on solid-state characteristics of amorphous dispersion and its impact on dissolution and solubility of Repaglinide, a BCS Class II drug. Solid dispersions of…
Nanocarrier-hydrogel composite delivery systems for precision drug release
Hydrogels are a class of biomaterials widely implemented in medical applications due to their biocompatibility and biodegradability. Despite the many successes of hydrogel-based delivery systems, there remain challenges to hydrogel drug…
Investigation on Formulation Strategies to Mitigate Compression-Induced Destabilization in…
Compression-induced destabilization was investigated in various celecoxib amorphous solid dispersions containing hydroxypropyl methylcellulose (HPMC), poly(vinylpyrrolidone)/vinyl acetate copolymer (PVP/VA), or poly(vinylpyrrolidone) (PVP)…
Fabrication of Injectable Chitosan-Chondroitin Sulfate Hydrogel Embedding Kartogenin-Loaded…
Ultrasound-responsive microspheres (MPs) derived from natural polysaccharides and injectable hydrogels have been widely investigated as a biocompatible, biodegradable, and controllable drug delivery system and cell scaffolds for tissue…
Ophthalmic Nanoemulsions: From Composition to Technological Processes and Quality Control
Nanoemulsions are considered as the most promising solution to improve the delivery of ophthalmic drugs. The design of ophthalmic nanoemulsions requires an extensive understanding of pharmaceutical as well as technological aspects related…
Pharmatrans adds SANAQ® SP205 and SP206 to Direct Compression excipients range
Pharmatrans Sanaq has added SANAQ® SP 205/206 to its DiCom range of Co-Processed Excipients supporting Direct Compression (DC) applications.
DiCom SANAQ® SP205 and SP206 are both based on microcrystalline cellulose (MCC), co-processed…
Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin
Vancomycin (Van) is a key antibiotic of choice for the treatment of systemic methicillin resistant Staphylococcus aureus (MRSA) infections. However, due to its poor membrane permeability, it is administered parenterally, adding to the cost…
Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process…
Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is…
Lipid nanostructures for targeting brain cancer
Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to…
3D Printing: an appealing technology for the manufacturing of solid oral dosage forms
Objectives
The traditional manufacturing methods of solid oral dosage forms (SODFs) are reported to be time-consuming, highly expensive and not tailored to the patient’s needs. Three-dimensional printing (3DP) is an innovative emerging…
Effects of Surface Pretreatment of Titanium Substrates on Properties of Electrophoretically…
The preparation of the metal surface before coating application is fundamental in determining the properties of the coatings, particularly the roughness, adhesion, and corrosion resistance. In this work, chitosan/Eudragit E 100 (chit/EE100)…
Rectal bioavailability of amoxicillin sodium in rabbits: Effects of suppository base and drug dose
In this paper, rectal absorption and tissue tolerance of amoxicillin sodium (AS) suppositories prepared in a hydrophilic base, polyethylene glycol (PEG) or lipophilic base, Suppocire® NA 15 (SNA 15), were investigated. Following in vitro …
Predicting Drug Release from 3D Printed Oral Medicines Based on the Surface Area to Volume Ratio of…
3D printing offers the advantage of being able to modify dosage form geometry, which can be exploited to modify release characteristics. In this study, we investigated the influence of the surface area to volume ratio (SA/V) to change and…
Tunable multi-responsive nano-gated mesoporous silica nanoparticles as drug carriers
Tunable multi-responsive mesoporous silica nanoparticles were prepared by post-condensation/surface modification of MCM-41 nanoparticles. Surface grafting of a poly(N,N-dimethylaminoethyl methacrylate)-based polymer containing disulfide…
Use of nanosystems to improve the anticancer effects of curcumin
Curcumin (CUR) is a phenolic compound that is safe for human consumption. It exhibits chemopreventive, antiproliferative, antiangiogenic, and antimetastatic effects. However, these benefits can be hampered due to the lipophilic nature,…
Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients:…
The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation of orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties of four lactose-based CPEs -…
Topical ocular delivery of vancomycin loaded cationic lipid nanocarriers as a promising and…
Vancomycin (VCM) is a drug of choice for treating infections caused by Staphylococcus species, reported being the most causative agent of bacterial endophthalmitis. However, the ocular bioavailability of topically applied VCM is low due to…
Impact of Alkanediols on Stratum Corneum Lipids and Triamcinolone Acetonide Skin Penetration
Alkanediols are widely used as multifunctional ingredients in dermal formulations. In addition to their preservative effect, considering their possible impact on drug penetration is also essential for their use. In the present study, the…
Development of Glimepiride Loaded Sustained Release Microparticles Using Tubular Microreactor
Background: Glimepiride is a third-generation, oral anti-diabetic sulfonylurea drug, generally recommended for the treatment of type–II diabetes. A biocompatible polymer, Eudragit RS 100 is widely used for the preparation of targeted and…