World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of…
Background: Ziyuglycoside I (ZgI), an active ingredient isolated from traditional Chinese medicine Sanguisorba officinalis L, has been demonstrated to increase the leucocytes and protect hematopoietic stem cells. However, the poor…
Preliminary study for the development of potent hydrogels for local drug delivery applications
Currently, design and development of formulations for the oral cavity and local application is a rather challenging process since the components should be non-irritant and provide relief. Hydrogels-based drug delivery systems have been…
Monitoring the microenvironment inside polymeric micelles using the fluorescence probe…
6-propionyl-2-dimethylaminonaphthalene (PRODAN) is a fluorescent molecule with sensitivity to environmental polarity and hydrogen bond interactions. Although it has been extensively used to study organized systems such as vesicles and…
Predicting the particle size distribution in twin screw granulation through acoustic emissions
A non-destructive process analytical technology for monitoring the complex particle size distributions inherent to twin screw granulation (TSG) was presented, based on acoustic emissions (AE). AE spectra were collected during the wet…
New Glatt webinar: The impact of coronavirus on comparator sourcing in clinical trials
Monday, 18 October 2021 – 03:00 PM CEST | 09:00 AM EST
In this presentation there will be a critical review of the impact that the Coronavirus pandemic has had on comparator studies and to a lesser extent clinical trials in general.
We…
Solid Dispersion Product Families
The right solution for your formulation challenges
Equipped with an in-depth understanding of multiple industries, technologies and applications, BASF has the skills and resources to make drug manufacturing more efficient, robust, and…
Connected Healthcare: Improving Patient Care using Digital Health Technologies
Now more than ever, traditional healthcare models are being overhauled with digital technologies of Healthcare 4.0 being increasingly adopted. Worldwide, digital devices are improving every stage of the patient care pathway. For one,…
Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing
Quercetin (QCT) is an effective antioxidant, antifibrotic and wound healing agent. Silver nanoparticles (AgNPs) are an effective antimicrobial and wound healing agent and considered as gold standard for wound treatment especially diabetic…
Spray (micro) encapsulation of sensitive substances in matrix form: An overview of essential oil and…
Phytochemicals are increasingly found in many food, chemical and agricultural items. Product and process optimization is becoming ever-more important in all of these industries, with a focus on quality, manufacturing efficiency, stability…
Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in…
Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling…
Opposing Effects of Additives in Dry Milling and Tableting of Organic Particles
Applying additives and excipients during the dry processing of fine particles is a common measure to control the particle–particle interactions, to specifically influence the powder properties and to enhance the process efficiency or…
Tacrolimus Encapsulated Mesoporous Silica Nanoparticles Embedded Hydrogel for the Treatment of…
Atopic dermatitis (AD) is a repetitive inflammatory skin disorder with limited treatment options. Innovative targeted therapies are gaining significant interest and momentum towards disease control including better ways to deliver drugs…
Nanoparticle-Based Drug Delivery System: The Magic Bullet for the Treatment of Chronic Pulmonary…
Chronic pulmonary diseases encompass different persistent and lethal diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), asthma, and lung cancers that affect millions…
Cyclodextrin-based supramolecular low melting mixtures: efficient absorbents for volatile organic…
Cyclodextrins (CDs) and deep eutectic solvents (DESs) are emerging absorbent materials for the removal of volatile organic compounds (VOCs). In this study, we have used combination of modified CDs and levulinic acid to form four DESs…
pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A…
Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting…
Surface tailored zein as a novel delivery system for hypericin: Application in photodynamic therapy
Zein is an FDA-approved maize protein featured by its manipulative surface and the possibility of fabrication into nanomaterials. Although extensive research has been carried out in zein-based technology, limited work is available for the…
Webinar: Multiparticulates Part 8: Scale up considerations on the Wurster (bottomspray) fluidized…
Scale up of manufacturing processes is an important step in drug development – not to say: a big hurdle! The Wurster (bottomspray) fluidized bed process is based on a clear technical concept. For scale up, configuration of the process…
Ultrasound-Responsive Smart Drug Delivery System of Lipid Coated Mesoporous Silica Nanoparticles
The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid…
Machine learning predicts 3D printing performance of over 900 drug delivery systems
Three-dimensional printing (3DP) is a transformative technology that is advancing pharmaceutical research by producing personalized drug products. However, advances made via 3DP have been slow due to the lengthy trial-and-error approach in…
Webinar: Stress-induced excipient function-switching: Neusilin transformation from glidant to binder…
Register now for the new & free webinar from Fuji Chemical Industries!
27th September 2021 - 10:00 AM CEST
Key discussions:
Neusilin behaviour
Free flowing powder
Acts as a glidant
Neusilin acts as a binder under…
Interview with Ilias El Aita about the current developments and the future of 3D-printing
3D printing is one of the current hot topics in the pharmaceutical industry. There are so many different applications and new ones are being added almost daily. Many companies are doing their own trials and producing materials and…
From oral formulations to drug-eluting implants: using 3D and 4D printing to develop drug delivery…
Since the start of the Precision Medicine Initiative by the United States of America in 2015, interest in personalized medicine has grown extensively. In short, personalized medicine is a term that describes medical treatment that is tuned…
Bioadhesive liquid crystal systems for octyl methoxycinnamate skin delivery
Excessive exposure to ultraviolet radiation stemmed from sunlight can cause harm to human skin. An alternative to avoid and reduce the effects of ultraviolet radiation is the use of sunscreens. The sunscreen octyl methoxycinnamate (OMC) is…
Modulated approaches for strategic transportation of proteins and peptides via ocular route
The influence of macromolecules in major eye disorders including retinal neovascularization, retinopathy, age-related macular degeneration, choroidal neovascularization, etc. offers substantial advantages in the development of formulations,…
Ellagic acid-loaded, tween 80-coated, chitosan nanoparticles as a promising therapeutic approach…
Aims
Among polyphenolic phytoconstituents with anticancer properties, Ellagic acid (EA) is widely reported for its translational potential in vitro but efficient in vivo delivery of EA has been a challenge. We, for the first time, used a …
Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of…
The aim of this study was to develop and optimize a self-emulsifying drug delivery system (SEDDS) containing an extract of calyces from Physalis peruviana with high mucus permeating properties to increase the bioavailability and the …
Formulation development and in-vitro evaluation of dexlansoprazole loaded double walled microspheres
In the present work, double walled microspheres of Dexlansoprazole using Sodium alginate, HPMC E15, Xanthan gum, Ethyl cellulose as copolymers and along with Carbopol were formulated to deliver Dexlansoprazole through oral route. Details…
3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular…
Monitoring of high-load dose formulations based on co-processed and non co-processed excipients
This work presents the evaluation of a co-processed material for high-load dose formulations and its real-time monitoring by near-infrared (NIR) spectroscopy at the tablet press feed frame. The powder and tableting properties of…
Resveratrol Loaded Cubic Phase Nanoparticles with Enhanced Oral Bioavailability
Resveratrol (RES), a naturally occurring hydrophobic polyphenolic compound, has shown potential anticancer activity. However, due to low aqueous solubility and extensive first pass metabolism (primarily by cytochrome enzymes), it shows poor…
Artificial Neural Networks to Predict the Apparent Degree of Supersaturation in Supersaturated…
In response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent degree of…
Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms
The pediatric population suffers from a lack of age-appropriate medicines leading to unsafe situations when off-labelled or unlicensed drugs are used. Assessing the best option to administrate medicines when manipulations are required is…
Electrophoretic Deposition and Characterization of Chitosan/Eudragit E 100 Coatings on Titanium…
Currently, a significant problem is the production of coatings for titanium implants, which will be characterized by mechanical properties comparable to those of a human bone, high corrosion resistance, and low degradation rate in the body…
Development of dexamethasone-loaded mixed polymeric micelles for nasal delivery
Our study aimed to formulate a novel dexamethasone (DXM)-loaded, mixed polymeric micelle-based drug delivery system, focusing on the auspicious nose-to-brain pathway, as a key delivery route to treat central nervous system (CNS) associated…