Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems. For each formulation ingredient, expert…
Solid dispersions: improving drug performance through tablet micro-structure design
Purpose Solid dispersions formulations manufactured by Hot-Melt-Extrusion (HME) have shown to improve drug release for BCS class II drugs, such as Mefenamic acid (MFA). Drug release for MFA is highly dependent on particle size. Commercially…
Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and…
Lipid nanoparticles have been widely investigated for their use as either carriers for poorly water soluble actives or as (Pickering) emulsion stabilisers. Recent studies have suggested that the fabrication of lipid nanostructures that can…
An in vitro approach to study the absorption of a new oral formulation of berberine
Background
Berberine (BBR) possesses several biological activities in humans, but the poor water solubility and low oral bioavailability preclude its pharmacological use. To overcome these limitations, several formulations have been…
Mesoporous silica nanoparticles for pulmonary drug delivery
Over the last years, respiratory diseases represent a clinical concern, being included among the leading causes of death in the world due to the lack of effective lung therapies, mainly ascribed to the pulmonary barriers affecting the…
Flowing properties of spray-dried powders before and after granulation
Abstract
We study the flowing properties, the density and the packing dynamics of spray-dried powders produced with different nozzels and different airflow rates. At the exception of one powder, the obtained grains are small and have a low…
Evaluation of two novel co-processed excipients for direct compression of orodispersible tablets and…
Pediatric, geriatric, and other patients who suffer from swallowing difficulties represent a special patient group, where an increased need in appropriate formulation development is required. To overcome these mostly swallowability linked…
Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential…
At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin…
Ionic Liquid-Based Catanionic Vesicles: A De Novo System to Judiciously Improve the Solubility,…
Highlights
• Ester functionalized surface active ionic liquids were synthesized.
• Biodegradable and biocompatible catanionic vesicles were prepared.
• Analytical techniques were used to study the structure of catanionic…
Single-crystal Drying: Development of a Continuous Drying Prototype to Optimize Particle Flow and…
Purpose
In the pharmaceutical industry, there has been a growing interest in continuous manufacturing in recent years. Many efforts have been made to implement new process equipment for various production steps. One step which is not yet…
Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer
Highlights
• Microneedles are promising devices used for painless transdermal drug delivery.
• Biological effects of therapeutic agents can be improved by tuning their release behavior.
• Microneedles can be…
Fluidization characterization in the ConSigma 25 dryer via process data – A method of advanced…
Highlights
• Model based approach to quantify fluidization quality, exclusively using the temperature profile.
• Approach is suited for drying end-point detection in real-time due to low computational complexity.
• Systematic…
A “cluster bomb” oral drug delivery system to sequentially overcome the multiple absorption barriers
Oral drugs have been widely used in clinical therapy, but their developments were severely limited by the side effects of drug exposure as well as the multiple biological barriers. In this study, we constructed a “cluster bomb” oral drug…
Development of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery…
The role of mushroom polysaccharides and probiotics as pharmaceutical excipients for development of nanocarriers has never been explored. In the present study an attempt has been made to explore Ganoderma lucidum extract powder (GLEP)…
Inhalable bedaquiline-loaded cubosomes for the treatment of non-small cell lung cancer (NSCLC)
Highlights
• Bedaquiline-loaded cubosomes (BQLC) displayed excellent particle size, zeta potential, and aerosolization behavior suitable for NSCLC treatment.
• BQLCs were efficiently internalized by lung cancer cells and decreased…
Implementing risk-based quality by design for development and optimization of flavored oral…
Paediatric patients differ from adult in various aspects of pharmacotherapy, including the abilities of drug admistration, medicine related toxicity and taste partialities. It is very much important that paediatrics drugs should best fit…
Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible…
Minitablets in orodispersible form constitute a flexible drug delivery tool for paediatric and geriatric population as they eliminate the risk of chocking and do not require drinking water in the application. Due to their direct contact…
Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates…
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in…
Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion…
The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid…
Solid self Nano-Emulsifying system for the enhancement of dissolution and bioavailability of…
Prasugrel Hydrochloride (PHCl) is an antiplatelet drug. It is a class II drug with variable bioavailability. The objective of this work was to enhance the solubility and hence the bioavailability and efficacy of PHCl. A Self…
Surfactants influence polymer nanoparticle fate within the brain
Drug delivery to the brain is limited by poor penetration of pharmaceutical agents across the blood-brain barrier (BBB), within the brain parenchyma, and into specific cells of interest. Nanotechnology can overcome these barriers, but…
Artificial intelligence based design of 3D-printed tablets for personalised medicine
Highlights
• Computational design of 3D-printed pharmaceutical tablets with multiple active ingredients.
• Evolutionary algorithm implemented for solving the inverse problem of tablet dissolution.
• Design space effectively…
Identifying the most relevant tablet regions in the image detection of counterfeit medicines
This paper proposes a novel image-based approach to detect counterfeit medicines and identify the most relevant regions of the tablet in the task of classification. Images of medicine tablets undergo an initial pre-processing step which (i)…
Solventless-mixing layering using a high shear mixer for preparing drug pellets: A feasibility study…
Our aim was to investigate the feasibility of mechanical-mixing layering using a high shear mixer, which can produce drug pellets by simply mixing drug crystals and inactive seed particles without the need for solvents or binders.…
Exploring the unexpected behavior of HPMC matrix tablets in dissolution media with SDS
In the case of poorly soluble drugs, a surfactant is often added to dissolution media to increase drug release. In this study, diclofenac sodium (DF-Na) release from hydroxypropyl methylcellulose (HPMC) matrix tablets was explored in…
Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients
The development of personalised paediatric dosage forms using 3D printing technologies has gained significant interest over the last few years. In the current study extruded filaments of the highly bitter Diphenhydramine Hydrochloride (DPH)…
Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of…
Background: The purpose of this study was to screen various drug delivery systems for improving the aqueous solubility and oral bioavailability of sildenafil. Three representative techniques, solid self-nanoemulsifying drug delivery systems…
Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery
A variety of polymer:polymer blends was used to prepare hot melt extrudates and empty capsules (bodies and caps) by injection molding using a benchtop extruder (Babyplast). Kollidon SR:inulin and Carbothane:inulin blends were investigated.…
Lipid-based formulations of microemulsion-loaded oleogels for the oral delivery of carvedilol
This work aimed to develop controlled-release lipid-based formulations of microemulsion-loaded oleogels for the oral delivery of the poorly soluble drug carvedilol (CARV). The microemulsion-loaded oleogels were prepared by the oleogelator…
Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between…
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid…
N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic…
N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and biomedical fields. In this study, TMC was used as a mucoadhesive adjuvant to enhance the oral…
Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
Microphysiological in vitro systems are platforms for preclinical evaluation of drug effects and significant advances have been made in recent years. However, existing microfluidic devices are not yet able to deliver compounds to cell…
Review: Continuous Manufacturing of Small Molecule Solid Oral Dosage Forms
Continuous manufacturing (CM) is defined as a process in which the input material(s) are continuously fed into and transformed, and the processed output materials are continuously removed from the system. Continuous manufacturing can be…
Evaluation of the Antitumor Effect and Immune Response of Micelles Modified with a Polysialic…
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has shown potential applications in cancer therapy owing to its attractive properties, including reversal of multi-drug resistance and synergistic effects with antitumor drugs.…
Bioavailability enhancement of nanostructured microparticles of carvedilol
A high throughput encapsulation technique termed as electrospraying assisted by pressurized gas technology (EAPG) was used to produce nano-within-micro structures of a Biopharmaceutics Classification System (BCS) Class II model drug. …