World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic…
N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and biomedical fields. In this study, TMC was used as a mucoadhesive adjuvant to enhance the oral…
Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
Microphysiological in vitro systems are platforms for preclinical evaluation of drug effects and significant advances have been made in recent years. However, existing microfluidic devices are not yet able to deliver compounds to cell…
Review: Continuous Manufacturing of Small Molecule Solid Oral Dosage Forms
Continuous manufacturing (CM) is defined as a process in which the input material(s) are continuously fed into and transformed, and the processed output materials are continuously removed from the system. Continuous manufacturing can be…
Evaluation of the Antitumor Effect and Immune Response of Micelles Modified with a Polysialic…
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has shown potential applications in cancer therapy owing to its attractive properties, including reversal of multi-drug resistance and synergistic effects with antitumor drugs.…
Bioavailability enhancement of nanostructured microparticles of carvedilol
A high throughput encapsulation technique termed as electrospraying assisted by pressurized gas technology (EAPG) was used to produce nano-within-micro structures of a Biopharmaceutics Classification System (BCS) Class II model drug. …
Development of Chitosan/Cyclodextrin Nanospheres for Levofloxacin Ocular Delivery
Levofloxacin (LVF) is an antibacterial drug approved for the treatment of ocular infections. However, due to the low ocular bioavailability, high doses are needed, causing bacterial resistance. Polymeric nanospheres (NPs) loading antibiotic…
NIR spectroscopy for monitoring of the critical manufacturing steps and quality attributes of…
The present work aimed to develop near-infrared (NIR) methods for the in-line monitoring of the powder blending process and off-line prediction of paliperidone tablets quality attributes.
The powder blending monitoring method was developed…
3D printing and enteric coating of a hollow capsular device with controlled drug release…
This work focuses on the extrusion of a brittle, tacky, cationic copolymer i.e., Eudragit® E-100 to prepare filament and subsequent 3D printing of hollow capsular device using the extruded filament. An optimum amount of talc and triethyl…
Statistical design of experiment-based formulation development and optimization of 3D printed oral…
Purpose
Producing several controlled- release 3D printed tablets from polymer blends with the required target product profile has been a challenge. Thus, experimental design could be applied to rationally explore the impact of the…
Vitamin E-tocopheryl polyethylene glycol succinate decorated drug delivery system with synergistic…
To overcome cancer drug resistance and to reverse tumor immunosuppression, a vitamin E-tocopheryl polyethylene glycol succinate (TPGS) decorated polymer-based drug delivery system was developed. The effects of the drug delivery system on…
Biocompatibility studies of polyurethane electrospun membranes based on arginine as chain extender
Electrospun polymers are an example of multi-functional biomaterials that improve the material-cellular interaction and aimed at enhancing wound healing. The main objective of this work is to fabricate electrospun polyurethane membranes…
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Controlled brimonidine release from nanostructured lipid carriers-laden silicone contact lens to…
A novel brimonidine-loaded nanostructured lipid carriers (Br-NLCs)-laden silicone contact lenses were designed for control ocular delivery of brimonidine for effective treatment of glaucoma. The Br-NLCs were found to be spherical in shape…
Poloxamer 188 Exerts Direct Protective Effects on Mouse Brain Microvascular Endothelial Cells in an…
Traumatic Brain Injury (TBI), the main contributor to morbidity and mortality worldwide, can disrupt the cell membrane integrity of the vascular endothelial system, endangering blood–brain barrier function and threatening cellular…
Kolliphor® HS 15-cyclodextrin Complex for the Delivery of Voriconazole: Preparation,…
Background: This study aimed to reduce the amount of sulfobutylether-β-cyclodextrin (SBECD) used in the marketed voriconazole injections to meet the clinical needs of patients with moderate-to-severe renal impairment (creatinine clearance…
Development of agomelatine nanocomposite formulations by wet media milling
Nanocrystal formulations of the BCS class II agomelatine, were developed by wet media milling. The most suitable stabilizer was identified and effects of process and formulation variables on the nanocrystal size and ζ-potential were…
Self-dispersing self-assembling systems for controlled oral delivery of gliclazide
Self-microemulsifying systems undergo self-dispersion to form microemulsion with subsequent self-assembly to form liquid crystalline (LC) and/or gel phases. These transitions modulate the release and absorption pattern of loaded drug.…
Effervescent floating matrix tablets of a novel anti-cancer drug neratinib for breast cancer…
The main purpose of this study was to develop a novel gastro-retentive drug delivery system via effervescent technique for the treatment of breast cancer. Neratinib (NTB) is a novel anticancer drug, poorly soluble at higher pH, was been…
Recent and Relevant Methodology in the Advancement of Solid Dispersion
Most of the promising drugs in development channels are poorly water-soluble drugs which limit formulation approaches, clinical application because of their low dissolution and bioavailability. And the major current challenges of the…
Ask the Expert – Q&A with Dr Maj-Britt Cepok about the latest excipient trends!
Q: When choosing a pharmaceutical excipient, what should I pay attention to and what’s currently driving the excipients market?
A: Dr Maj-Britt Cepok, Head of Business Development Pharma at BENEO, says:
The global pharmaceutical…
Cellulose derivatives as effective recrystallization inhibitor for ternary ritonavir solid…
Amorphous solid dispersions (ASDs) are regarded as one of the most promising techniques for poorly-soluble active pharmaceutical ingredients (API). However, the thermodynamic instability of ASDs at supersaturated state makes them easy to…
Development of a furosemide-containing expandable system for gastric retention
More than 50 years ago, the first gastroretentive dosage forms came up. Since then, no practical and at the same time reliable gastroretentive system is available on market. A major obstacle in the development of novel gastroretentive…
Big family of nano- and microscale drug delivery systems ranging from inorganic materials to…
Traditional drug administration routs suffer from low selective distribution, poor solubility, fast elimination and damaging adjacent healthy tissues (especially in cancer therapy). Thus, drug delivery systems (DDSs) which could deliver…
Aqueous Film Coating the Current Trend
The presentation of this work aims to update professionals involved with aqueous film coating (AFC) of pharmaceuticals on facts associated with film coating (FC) based on aqueous solvent (AS). Initially sugar coating (SC) was the first…
In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion…
Amorphous solid dispersion (ASD) dosage forms can improve the oral bioavailability of poorly water-soluble drugs, enabling the commercialization of new chemical entities and improving the efficacy and patient compliance of existing drugs.…
Nanofibers in Drug Delivery System
The possible applications of electrospun fibers in drug delivery systems (DDS) are critically examined in this study. Nanofibers are among the most desirable resources in some kind of a variety of scenarios due to their operational…
Devices for drug delivery in the gastrointestinal tract: a review of systems physically interacting…
The delivery of macromolecules via the gastrointestinal (GI) tract remains a significant challenge. A variety of technologies using physical modes of drug delivery have been developed and investigated to overcome the epithelial cell layer…
Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun…
Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell…
Formulation of pH responsive multilamellar vesicles for targeted delivery of hydrophilic antibiotics
Fight against antimicrobial resistance calls for innovative strategies that can target infection sites and enhance activity of antibiotics. Herein is a pH responsive multilamellar vesicles (MLVs) for targeting bacterial infection sites. The…
Natural and bioinspired excipients for dry powder inhalation formulations
Pulmonary drug delivery can have several advantages over other administration routes, in particular when using dry powder formulations. Such dry powder inhalation formulations generally include natural and bio-inspired excipients, which,…
Stabilizing proteins with high-purity excipients
Shield your protein of interest from challenging conditions throughout the manufacturing process and increase shelf life with Merck's high purity stabilizers. Learn how you can minimize regulatory and quality-associated risks in your…
Production of lipophilic nanogels by spontaneous emulsification
Nanosized gel particles, so-called nanogels, have attracted substantial interest in different application fields, thanks to their controllable and three-dimensional physical structure, good mechanical properties and potential…
Improved Bioavailability with Dry Powder Cannabidiol Inhalation: A Phase 1 Clinical Study
Oral cannabidiol (CBD) is approved by the Food and Drug Administration (FDA) to treat patients with Dravet and Lennox-Gastaut syndromes, and tuberous sclerosis complex. The therapeutic potential of oral CBD formulations is limited by…
Using a material database and data fusion method to accelerate the process model development of high…
High shear wet granulation (HSWG) has been wildly used in manufacturing of oral solid dosage (OSD) forms, and process modeling is vital to understanding and controlling this complex process. In this paper, data fusion and multivariate…