World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Cellulase as an “active” excipient in prolonged-release HPMC matrices: a novel strategy towards…
Hydrophilic matrices are of utmost interest for oral prolonged release of drugs. However, they show decreasing release rate over time, mainly due to lengthening of the diffusional pathway across the gel formed upon glass-rubber transition…
Recent Development in Pharmaceutical 3D Printing: A Bird’s Eye Perspective
Pharmaceutical product development is constantly witnessing advancements in the creation of novel delivery methods in order to enhance medication therapeutic effectiveness. Furthermore, 3D printing (3DP) has been utilized to produce…
Polymers in Pharmaceutical Additive Manufacturing A Balancing Act Between Printability and Product…
Materials and manufacturing processes share a common purpose of enabling the pharmaceutical product to perform as intended. This review on the role of polymeric materials in additive manufacturing of oral dosage forms, focuses on the…
Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation
The granulation technique and the binder have an essential influence not only on the granules properties, but also on the properties of the final dosage form. Thermoplastic granulation is a process in which solid particles are converted…
Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from…
The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate of water insoluble drugs in a simplistic approach. However, there is no current study on…
Web-Seminar series: Advances In Amorphous Solid Dispersion Technologies: Spray drying
In this series of webinars we will discuss the latest developments in the fields of amorphous solid dispersion (ASD) focusing on Excipient Key Attributes linked to the most popular technologies: Hot Melt Extrusion (HME), Spray Drying and…
Impact of Drug–Polymer Intermolecular Interactions on Dissolution Performance of Copovidone-Based…
For poorly soluble drugs formulated as amorphous solid dispersions (ASDs), fast and complete release with the generation of drug-rich colloidal particles is beneficial for optimizing drug absorption. However, this ideal dissolution profile…
Development of a dry powder for inhalation of nanoparticles codelivering cisplatin and ABCC3 siRNA…
Background: The current study sought to formulate a dry powder inhalant (DPI) for pulmonary delivery of lipopolymeric nanoparticles (LPNs) consisting of cisplatin and siRNA for multidrug-resistant lung cancer. siRNA against ABCC3 gene was…
What Are the Important Factors That Influence API Crystallization in Miscible Amorphous…
In this perspective, the authors examine the various factors that should be considered when attempting to use miscible amorphous API–excipient mixtures (amorphous solid dispersions and coamorphous systems) to prevent the solid-state…
Multiparticulates Part 8: Scale up considerations on the Wurster (bottomspray) fluidized bed process
Scale up of manufacturing processes is an important step in drug development – not to say: a big hurdle! The Wurster (bottomspray) fluidized bed process is based on a clear technical concept. For scale up, configuration of the process…
Lipid Based Formulations in Hard Gelatin and HPMC Capsules: A Physical Compatibility Study
Purpose
To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients.
Methods
The miscibility was investigated for 350 systems…
Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos
A significant proportion of recently approved drug molecules possess poor aqueous solubility which further restrains their desired bioavailability. Poor aqueous solubility of these drugs poses significant hurdles in development of novel…
Temperature Effect on the Adsorption and Volumetric Properties of Aqueous Solutions of Kolliphor®…
Density, viscosity and surface tension of Kolliphor® ELP, the nonionic surfactant aqueous solutions were measured at temperature T = 293–318 K and at 5K interval. Steady-state fluorescence measurements have been also made using pyrene as a…
Solvent mixtures in pharmaceutical development: Maximizing the API solubility and avoiding phase…
Knowing the solubilities of active pharmaceutical ingredients (APIs) in pure solvents and solvent mixtures is essential for several manufacturing aspects of pharmaceutical product development. In this paper, we demonstrate that…
Polymers in Pharmaceutical Additive Manufacturing: A Balancing Act Between Printability and Product…
Materials and manufacturing processes share a common purpose of enabling the pharmaceutical product to perform as intended. This review on the role of polymeric materials in additive manufacturing of oral dosage forms, focuses on the…
Solving Bioavailability Challenges Using A Molecule’s Target Product Profile (TPP)
What is the Target Product Profile (TPP)?
The Target Product Profile (TPP) describes the desired characteristics of the proposed drug product aimed at a particular disease. We consider the TPP to be a living document that may change as…
Lipids for pharmaceutical applications from Merck
Lipids are the most commonly used delivery method for RNA therapeutics and vaccines, and lipid nanoparticles could prove a game changer for COVID-19 and many other diseases.
Lipids for passive and active targeting
Surface modification on…
Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug…
Among many methods to mitigate the solubility limitations of drug compounds, amorphous solid dispersion (ASD) is considered to be one of the most promising strategies to enhance the dissolution and bioavailability of poorly water-soluble…
Drug–Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous…
The bioavailability of insoluble crystalline active pharmaceutical ingredients (APIs) can be enhanced by formulation as amorphous solid dispersions (ASDs). One of the key factors of ASD stabilization is the formation of drug–polymer…
Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutic
Diabetes mellitus is a major health problem with increasing prevalence at a global level. The discovery of insulin in the early 1900s represented a major breakthrough in diabetes management, with further milestones being subsequently…
Dual Loaded Nanostructured Lipid Carrier of Nano-Selenium and Etravirine as a Potential Anti-HIV…
There is a dire need for dual-long-acting therapy that could simultaneously target different stages of the HIV life cycle and providing a dual-prolonged strategy for improved anti-HIV therapy while reducing oxidative stress associated with…
Subcutaneously Injectable Hyaluronic Acid Hydrogel for Sustained Release of Donepezil with Reduced…
The daily oral administration of acetylcholinesterase (AChE) inhibitors for Alzheimer’s disease features low patient compliance and can lead to low efficacy or high toxicity owing to irregular intake. Herein, we developed a subcutaneously…
Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions…
In the presented study, we report development of a stable, scalable, and high-quality curcumin-loaded oil/water (o/w) nanoemulsion manufactured by concentration-mediated catastrophic phase inversion as a low energy nanoemulsification…
Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular…
Oral insulin delivery could change the life of millions of diabetic patients as an effective, safe, easy-to-use, and affordable alternative to insulin injections, known by an inherently thwarted patient compliance. Here, we designed a…
SIMALINE™ L80 – Liquid emulsifier for Geltrap™ “Gel-in-oil” and traditional W/O emulsion from…
The value proposition for formulation scientists is:
A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients
Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to…
Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in…
Lipid-based formulations, such as self-microemulsifying drug-delivery systems (SMEDDSs), are promising tools for the oral delivery of poorly water-soluble drugs. However, failure to maintain adequate aqueous solubility after coming into…
Enhancing the Stabilization Potential of Lyophilization for Extracellular Vesicles
Extracellular vesicles (EV) are an emerging technology as immune therapeutics and drug delivery vehicles. However, EVs are usually stored at −80 °C which limits potential clinical applicability. Freeze-drying of EVs striving for long-term…
Antimicrobial Excipient-Induced Reversible Association of Therapeutic Peptides in Parenteral…
New classes of therapeutic peptides are being developed to prosecute biological targets which have been inaccessible to other modalities. Higher potency and longer half-life peptides have given rise to multiuse injectable formulations that…
FAQ about the EFSA decision on titanium dioxide (E171)
Lately, we've kept reporting on the latest TiO2 developments, from the 2019 ban in France, to the 2021 EFSA decision in food and feed.
To clarify the basic questions about the EFSA decision on TiO2, we provide a titanium dioxide FAQ:…
Lipid Nanoparticles – From Liposomes to mRNA Vaccine Delivery, a Landscape of Research…
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in…
Tribology provides an in vitro tool that correlated to in vivo sensory data on the mouthfeel of…
Tribology is an emerging technique in the pharmaceutical field for texture and mouthfeel studies. Due to its relevance to oral sensory perception, tribology supports the development of novel products in the food industry. This study…
Evaluation of Transmission Raman spectroscopy and NIR Hyperspectral Imaging for the assessment of…
The objective of the present study was to explore and compare fast and non-destructive Transmission Raman Spectroscopy (TRS) and Near Infrared Hyperspectral imaging (NIR HSI) for the development of predictive quantitative methods to…
See the overview of Parteck® Functional Excipients
When you design a solid dosage form, there are many factors to consider: the active ingredient, bioavailability enhancement, release kinetics, specific dosage, packaging, shelf life, and more.
Our Parteck® excipients were designed with…
Design and Development of Taste Masked Formulations of Model Drug by Using Eudragit L-100: A Recent…
Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor medication with a very bitter taste that plays an essential role in patient compliance in the oral dosing form. In this study, an attempt was made to mask the…