World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Preparation of solid dispersions with respect to the dissolution rate of active substance
Solid dispersions (SDs) are one of the successfully applied methods to improve the solubility and dissolution rates of poorly water-soluble drugs. SDs are commonly API-polymer systems, where API is molecularly dispersed in a polymeric…
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Have you ever wondered how much you know about excipients and formulations?
Try our new quiz now and get the answer!…
Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and…
Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to…
Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair
The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area…
Mucoadhesion and Mucopenetration of Cannabidiol (CBD)-Loaded Mesoporous Carrier Systems for Buccal…
Transmucosal drug delivery represents a promising noninvasive option when drugs are employed which have a low oral bioavailability like CBD. However, this concept can only be successful as long as the formulation provides sufficient buccal…
An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems
Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and…
Dapsone-Loaded Microsponge Gel for Acne Management: Preparation, Characterization and Anti-Microbial…
Background: Acne vulgaris is a chronic inflammatory disorder involving Propionibacterium acnes and activation of lymphocytes and neutrophils. Dapsone (sulfone drug) possesses potent anti-microbial activities and hence, it is used to cure…
Investigating microcrystalline cellulose crystallinity using Raman spectroscopy
Microcrystalline cellulose (MCC) is a semi-crystalline material with inherent variable crystallinity due to raw material source and variable manufacturing conditions. MCC crystallinity variability can result in downstream process…
Considerations for Dosing Accuracy in a New Carrier for Dry Powder Inhalation
Inhalation drug delivery methods are attractive, noninvasive routes when rapid onset of action, minimal side effects and excellent bioavailability are desired. However, not many drugs are administered this way and accurate dosing can be a…
Twin-screw Melt Granulation as alternative Granulation Strategy
Melt granulation is an interesting alternative technique to produce both, immediate and controlled-release final products using twin-screw extruders. The aim of this current work was to gain a deeper understanding of the granule’s…
Theoretical and experimental validation of praziquantel with different polymers for selection of an…
The selection of an appropriate matrix for the preparation of amorphous extrudate in hot-melt extrusion (HME) deals with the study of various solid-state properties of drugs and polymers. Therefore, it is necessary to have an appropriate…
Vinyl Polymer-based technologies towards the efficient delivery of chemotherapeutic drugs
The application of synthetic polymers as delivery systems of chemotherapy drugs has opened a very prospective field for research in cancer therapy. Due to their unique and attractive properties - biocompatibility, non-carcinogenicity,…
Nanostructured Fluids For Polymeric Coatings Removal: Surfactants Affect the Polymer Glass…
Hypothesis: Nanostructured fluids (NSFs) based on water, organic solvents and surfactants are a valid alternative to the use of neat unconfined organic solvents for polymer coatings removal in art conservation. The physico-chemical…
Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human…
In 2019, France made the decision to completely ban TiO2 in the nutraceutical sector from January 1, 2020. Now, the EFSA panel concluded, that E171 (TiO2) can no longer be considered as safe when used as a food additive in Europe on the…
Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms
Orodispersible dosage forms are attractive and innovative drug delivery systems that can fulfill individual patient needs, especially in children, elderly and among dysphagic patients. Indeed, they rapidly disperse in the mouth upon contact…
Formulation and Characterization of Eplerenone Mucoadhesive Buccal Tablets
Mucoadhesive drug release system is a preferably unidirectional release system where mucosal epithelial exterior is enclosed by the mucus deposit that interacts with the bio-adhesive drug delivery system and swelling time of the buccal…
Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for…
Diazepam is commonly used in the management of epileptic seizures, although it has limitations that can be overcome by using formulations that are easier to administer and capable of directing the drug to the brain. In this field, it has…
Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous…
This research demonstrates the influence of laser speed and the drug particle size on the manufacturing of amorphous solid dispersions (ASD) and dosage forms thereof using selective laser sintering 3-dimensional (3D) printing. One-step…
Application of near-infrared spectroscopy in detecting residual crystallinity in carbamazepine –…
Amorphous solid dispersions can improve the solubility and dissolution rate of poorly soluble drugs. However, residual crystallinity can adversely affect the dissolution in formulations design to be in amorphous state. This study aimed to…
pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active…
Nano-drug delivery systems (nano-DDSs) with an existing specific interaction to tumor cells and intelligent stimulus-triggered drug delivery performance in a tumor microenvironment (TME) remain hotspots for effective cancer therapy. Herein,…
Solvent influence on manufacturability, phase behaviour and morphology of amorphous solid…
Bead coating or fluid-bed coating serves as an auspicious solvent-based amorphous solid dispersion (ASD) manufacturing technique in respect of minimization of potential physical stability issues. However, the impact of solvent selection on…
Designing a unique feedback mechanism for hydrogel-forming microneedle array patches: a concept…
Although microneedle array patch (MAP) technology is reaching ever closer to regulatory approval, it remains imperative that approaches to further improve patient acceptance are still explored. Addressing this perception, a water-filled…
Newly designed punch for scored tablets: Evaluation by an expert system based on quality by design
Scored tablets enable modulation of the drug dose and intake by elderly, pediatric and dysphagic patients. However, they are known to involve difficulties in splitting, problems of mass uniformity of portions and loss of mass on breaking. A…
The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets:…
Within this study, tablets microstructure was investigated by X-ray microtomgraphy. The aim was to gain information about their microstructure, and thus, derive deeper interpretation of tablet properties (mechanical strength, component…
Enhanced Bioavailability of AC1497, a Novel Anticancer Drug Candidate, via a Self-Nanoemulsifying…
AC1497 is an effective dual inhibitor of malate dehydrogenase 1 and 2 targeting cancer metabolism. However, its poor aqueous solubility results in low bioavailability, limiting its clinical development. This study was conducted to develop…
Hybrid polylactic acid/Eudragit L100 nanoparticles: A promising system for enhancement of…
Luteolin is a valuable natural drug for the treatment of oxidative stress associated diseases, but its use is hindered by gastric instability and poor bioavailability. Given that hybrid polymeric nanoparticles may have potential…
INSTACOAT T2F from Ideal Cures
Ideal Cures are continuously innovating to meet their customer’s demands. Responding to customer demand and current market trend of clean label ingredients, Ideal Cures launched a new product: Talc and Titanium dioxide free coating…
Design of experiment of redispersible spray dried powder of fatty acid-nanostructured lipid carriers…
Fatty acid such as lauric and oleic acid have been used extensively either in cosmeceutical or pharmaceutical products as an emollient or moisturiser. In this study, fatty acids which combine lauric and oleic acids have been formulated into…
SheffCoat™ TF – The new ready-to-use film coating system without the need for Titanium Dioxide…
At Kerry, we recognize the need to continually evolve our film coatings to ensure we meet our customer needs who require market appeal, as well as for ease of regulatory compliance. Introducing SheffCoat™ TF.
In the global dietary…
Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying…
Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying…
Exploring the affluent potential of glyceryl mono oleate – myristol liquid crystal nanoparticles…
This study aimed to design and characterize Tofacitinib (TF)-loaded lyotropic liquid crystalline nanoparticles (TF-LCNP) gel using quality by design-driven approach to enhance the skin delivery of TF. The present work investigated the…
Binder-free twin-screw melt granulation: an effective approach to manufacture high-dose API…
This study investigates the use of twin-screw binder-free melt granulation (BFMG) in the development of high-dose solid dose formulations for low melting point thermally stable drugs. Both ibuprofen and guaifenesin are examined. By…
Self-Assembling Dioscorea bulbifera loaded mixed micelles: Formulation optimization, in-vitro…
Dioscorea bulbifera (DB)is one among the traditionally used medicinal plant which has been reported to have anticancer property and capable of inducing apoptosis of tumors, but the poor water solubility restricts its pharmacological…
Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on…
Psoriasis is an autoimmune, inflammatory and chronic skin disease in which cell growth and proliferation are increased, causing erythema, lesions and skin's peeling. Oral methotrexate (MTX) is the first-choice drug when phototherapy or …