World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Biomedical Applications of Biodegradable Polymers in Wound Care
According to the World Health Organization, it is estimated that 180,000 deaths occur annually due to burns. In the United States, it is expected that chronic wounds (e.g., diabetic and pressure ulcers) affect 6.5 million people. Thus, skin…
Crust breakage in production of fine particles using pulse combustion drying: Experimental and…
The mechanism that leads to fine particle production during pulse combustion drying is still unclear. Although droplet breakup could happen, it cannot result in particles below micron-size. Here production of fine particles during pulse…
Manufacturing of 3D-Printed Microfluidic Devices for the Synthesis of Drug-Loaded Liposomal…
Microfluidic technique has emerged as a promising tool for the production of stable and monodispersed nanoparticles (NPs). In particular, this work focuses on liposome production by microfluidics and on factors involved in determining…
Exploration of a transdermal nanoemulgel as an alternative therapy for postmenopausal osteoporosis
The study investigated the ability of a transdermal nanoemulgel formulation to enhance the bioavailability and anti-osteoporotic efficacy of raloxifene hydrochloride (RH) using recent techniques such as micro-CT, SEM-EDX analysis. The…
3D Printed Intragastric Floating and Sustained-release Tablets with Air Chambers
This work aimed to use hot-melt extrusion (HME) and dual fused deposition modeling (FDM) 3D printing technology to develop a novel intragastric floating and sustained-release drug delivery system. The intragastric floating and…
Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery…
NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies…
Effect of processing conditions and material attributes on the design space of lysozyme pellets…
The present work aimed to investigate the impact of the critical material attributes on the design space of the production of lysozyme pellets with suitable biological and physical properties for the subsequent coating process. The effect…
Time-controlled release by the incorporation of superdisintegrants within the coat of zein dry…
The aim of this work was to develop zein-based press coated tablets for delayed, time-controlled drug release. Press coated tablets containing dextrates and chlorpheniramine maleate (BCS class 1 drug) in the core, and zein and either NaCl,…
Preparation of seeded granules to improve mechanical properties and various drug loading for…
The present work explores the pharmaceutical application of a novel seeded granulation to develop properties-improved, high drug-loaded, and sustained-release tablets using hydroxypropylcellulose (HPC) as a binder. Itraconazole,…
Design, optimization and pharmacokinetic evaluation of Piribedil loaded solid lipid nanoparticles…
Piribedil (PBD) is an anti-Parkinson’s drug that gained interest recently due to its unique pharmacological profile. But its clinical use is severely limited by drug delivery issues like high dosing frequency (up to 5 tablets/day), low oral…
Microneedle array with a pH-responsive polymer coating and its application in smart drug delivery…
For successful wound treatment, therapeutics must be delivered directly to the wound. Various issues restrict the delivery of antibiotics to wounds, including the barrier mannered by necrotic tissue and biofilms, which create an…
Formulation Development of Celecoxib Loaded Microsponges using Eudragit and Ethyl Cellulose
Background: Microsponge is a class of dosage form containing porous nature containing drug that is targeted to achieve sustained action for prolong period. Microsponge based delivery system results in drug localization on skin surface and…
Encapsulation of Phenolic Compounds from a Grape Cane Pilot-Plant Extract in Hydroxypropyl…
Grape canes, the main byproducts of the viticulture industry, contain high-value bioactive phenolic compounds, whose application is limited by their instability and poorly solubility in water. Encapsulation in cyclodextrins allows these…
Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based…
Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in…
Current status of nanoscale drug delivery and the future of nano-vaccine development for…
The study of tropical diseases like leishmaniasis, a parasitic disease, has not received much attention even though it is the second-largest infectious disease after malaria. As per the WHO report, a total of 0.7–1.0 million new…
Improved oral bioavailability, cellular uptake and cytotoxic activity of zingerone via nano-micelles…
Herein, a nano-micelle drug delivery system was developed to orally improved zingerone’s bioavailability and its antitumor effect. Indeed, zingerone-loaded D-α-tocopheryl polyethylene glycol succinate micelles (ZTMs) were effectively…
Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution
Abstract
Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition…
Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for…
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration. P-gp inhibitors,…
Tuning of Paroxetine 3D-Printable Formulations for Fused Deposition Modelling
This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing…
3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs
Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms.
In the present study,…
Omya launches new excipients for nutraceutical tablets
Minerals supplier Omya International AG (Switzerland) announced it will launch two new nutraceutical tablet excipients at this year’s Vitafoods Europe trade show taking place in October. Both new excipients are designed to overcome…
Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts
Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and,…
3D printing of drugs: expanding the options for child-tailored pharmacotherapy
Lack of age-appropriate commercially available drugs hinders adequate pharmacotherapy in children. The European Union Paediatric Regulation (EC No1901/2006) and the establishment of the EU Paediatric Committee PDCO (2007) were aimed to…
Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation…
For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide. However, there is no suitable paediatric formulation on the market,…
Pharmacotechnical and Analytical Preformulation Studies for Cannabidiol Orodispersible Tablets
Obtaining orodispersible tablets (ODT) containing substances from the 2nd Biopharmaceutical Class has raised concerns as the dissolution test is challenging. This study aimed to select suitable excipients for developing orodispersible…
Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film
Micro-reservoir based drug delivery systems have the potential to provide targeted drug release locally in the intestine, i.e. at the inflamed areas of the intestine of patients with inflammatory bowel disease (IBD). In this study,…
Screening of Surfactants for Improved Delivery of Antimicrobials and Poly-Lactic-co-Glycolic Acid…
Topical wound management is often a challenge due to the poor penetration of antimicrobials in wound tissue and across the biofilm matrix where bacteria are embedded. Surfactants have been used for decades to improve the stability of…
Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design
Herbal antioxidant like curcumin holds great potential to treat neurodegenerative disease like Alzheimer's disease. However, its therapeutic potency is obstructed due to rapid metabolism, poor solubility, GI susceptibility, enzymatic…
Oil adsorption with Fuji excipients
Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. We spray-dry our excipients to produce free-flowing granules and unique internal structures that enhance…
Enhanced Delivery of Neuroactive Drugs via Nasal Delivery with a Self-Healing Supramolecular Gel
This paper reports the use of a self-assembling hydrogel as a delivery vehicle for the Parkinson's disease drug l-DOPA. Based on a two-component combination of an l-glutamine amide derivative and benzaldehyde, this gel has very soft…
Sex Differences in Respiratory Viral Pathogenesis and Treatments
Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome…
Structure and Fate of Nanoparticles Designed for the Nasal Delivery of Poorly Soluble Drugs
Nanoparticles are promising mediators to enable nasal systemic and brain delivery of active compounds. However, the possibility of reaching therapeutically relevant levels of exogenous molecules in the body is strongly reliant on the…
3D printing technology on the verge to create booming growth in pharmaceuticals
1. Pharmaceutical 3D printing
Recent advancements in the area of 3D printing (3DP) have prompted scientists to test and evaluate the technology's applicability in the medical sector. Drug delivery systems, tissue engineering, tissue and…
Polymeric microneedles for transdermal delivery of nanoparticles: Frontiers of formulation,…
With the launch of few products in the market, transdermal drug delivery through microneedles (MNs) has evidenced a major leap. Interest in MNs is growing exponentially as it overcomes the limitations accompanying other delivery routes.…