World AIDS Day 2024
World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease's ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS.
The World AIDS Conference theme was…
Excipient combinations to manage protein viscosity for highly concentrated formulations
Purpose: When delivered via the subcutaneous route of application the volume of a drug is restricted to approx. 2 mL. For therapeutic proteins, such as mAbs or plasma proteins, this restriction requires the use of high protein…
Topical nanocarriers for management of Rheumatoid Arthritis: A review
Rheumatoid arthritis (RA) is a systemic autoimmune disease manifested by chronic joint inflammation leading to severe disability and premature mortality. With a global prevalence of about 0.3%–1% RA is 3–5 times more prevalent in women than…
High-Pressure Dielectric Studies—a Way to Experimentally Determine the Solubility of a Drug in the…
In this work, we employed broad-band dielectric spectroscopy to determine the solubility limits of nimesulide in the Kollidon VA64 matrix at ambient and elevated pressure conditions. Our studies confirmed that the solubility of the drug in…
Development of a thermostable oxytocin microneedle patch
Oxytocin is a nonapeptide hormone used in labor to initiate uterine contractions and to prevent and treat postpartum hemorrhage. Oxytocin is currently administered by injection and requires refrigerated transport and storage, which limits…
New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug…
The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. The novel…
Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug…
We seek to further address the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and…
Encapsulating cannabinoids in lipid-based nanoparticles: CBD vs. CBDA
Enhancing cannabinoids’ therapeutic efficacy
Cannabinoids have a long history in medicine given their therapeutic effects (1). However, due to their lipophilic nature, they are poorly absorbed by the digestive system which hinders their…
Women-specific routes of administration for drugs
The woman’s body presents a number of unique anatomical features that can constitute valuable routes for the administration of drugs, either for local or systemic action. These are associated with genitalia (vaginal, endocervical,…
Evaluation of the stability of a spray-dried tuberculosis vaccine candidate designed for dry powder…
Particle engineering via spray drying was used to develop a dry powder presentation of an adjuvanted tuberculosis vaccine candidate. This presentation utilizing a trileucine-trehalose excipient system was designed to be both thermostable…
Potential pharmacokinetic interaction between orally administered drug and osmotically active…
Poorly absorbable sugar alcohols (e.g., mannitol, sorbitol, and maltitol) are the excipients frequently contained in pediatric dosage forms. Due to their osmotically active properties, certain amount of sugar alcohols reportedly reduces…
Fused deposition modeling (FDM)-mediated 3D-printed mouth-dissolving wafers loaded with…
Localized delivery of drugs or nanoparticles for oral cancer is always preferred. Additive manufacturing (AM)-driven 3D-printed wafers to deliver nanoparticles offers a new dimension to the cutting-edge delivery perspective. Nanostructured…
Pulmonary Drug Delivery of Antimicrobials and Anticancer Drugs Using Solid Dispersions
It is well established that currently available inhaled drug formulations are associated with extremely low lung deposition. Currently available technologies alleviate this low deposition problem via mixing the drug with inert larger…
Optimized Taste-Masked Microparticles for Orally Disintegrating Tablets as a Promising Dosage Form…
The objective of this research was to optimize the tasted-masked microparticles for orally disintegrating tablets containing donepezil hydrochloride using quality risk assessment and design of experiment approaches. The double emulsion…
Hierarchical Particle Approach for Co-Precipitated Amorphous Solid Dispersions for Use in…
Amorphous solid dispersions (ASD) have become a well-established strategy to improve exposure for compounds with insufficient aqueous solubility. Of methods to generate ASDs, spray drying is a leading route due to its relative simplicity,…
Molecular Dynamics Simulations to Elucidate Translocation and Permeation of Active from Lipid…
One of the most realistic approaches that could deliver actives (pharmaceuticals/cosmetics) deep into skin layer is encapsulation into nanoparticles (NP). Nonetheless, molecular-level understanding into the mechanism of active delivery from…
Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized…
Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible carrier that permits the thermal processing of the mixture at temperature levels that are safe…
Application of SeDeM Expert System in the development of novel directly compressible co-processed…
Background
Computer-aided formulation design is gaining fantastic attention in chemical engineering of high functionality pharmaceutical materials for dosage form manufacture. To accelerate development of novel formulations in a…
Self-assembled micelles enhance the oral delivery of curcumin for the management of alcohol-induced…
Curcumin (CUR) shows great potential in the management of alcohol-use disorders. However, the hydrophobicity and poor oral bioavailability result in the limited therapeutic efficacy of CUR against alcohol-induced tissue injury. Here,…
The Formulation Finder for Topicals module is now available in ZoomLab™
This new, interactive module addresses both chemical and patient compatibility concerns, guiding ZoomLab™ users to the most suitable base cream formulations.
Topical formulation development is a complex process that requires consideration…
Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from…
The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate of water insoluble drugs in a simplistic approach. However, there is no current study on…
Lyophilization Preserves the Intrinsic Cardioprotective Activity of Bioinspired Cell-Derived…
Recently, bioinspired cell-derived nanovesicles (CDNs) have gained much interest in the field of nanomedicine due to the preservation of biomolecular structure characteristics derived from their parent cells, which impart CDNs with unique…
Recent Advances in Mesoporous Silica Nanoparticles for Targeted Drug Delivery applications
Nanotechnology provides the means to design and fabricate delivery vehicles capable of overcoming physiologically imposed obstacles and undesirable side effects of systemic drug delivery. This protocol allows maximal targeting effectiveness…
The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets:…
Within this study, tablets microstructure was investigated by X-ray microtomgraphy. The aim was to gain information about their microstructure, and thus, derive deeper interpretation of tablet properties (mechanical strength, component…
Hierarchical Bayesian approach applied to the formulation of sustained-release suppositories and…
The hierarchical Bayesian modeling approach was used to select the appropriate empirical kinetics model of sustained release and to optimize the in vitro dissolution rate of the sustained-release suppository by controlling the composition…
Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube…
The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method. To choose optimal excipient composition providing the sufficient…
Impact of Matrix Surface Area on Griseofulvin Release from Extrudates Prepared via Nanoextrusion
We aimed to examine the impact of milling of extrudates prepared via nanoextrusion and the resulting matrix surface area of the particles on griseofulvin (GF, a model poorly soluble drug) release during in vitro dissolution. Wet-milled GF…
The Development of Floating Multiple Unit Mini Tablets of Bosentan Using QbD: Characterisation and…
Background: Multiple dosing is required for bosentan in order to achieve steady-state concentration. Hence formulating bosentan controlled release formulation could be an approach to solve this issue.
Objective: The objective is to…
Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed…
Although hot melt extrusion (HME) has been used in combination with fused deposition modelling (FDM) three-dimensional printing (3DP), suitable feedstock materials such as polymeric filaments with optimum properties are still limited. In…
Drying in a continuous wet granulation line: Investigation of different end of drying control…
Continuous manufacturing in the pharmaceutical industry has been gaining traction in the past few years. To fully understand and optimise continuous manufacturing processes it is important not only to focus on the single units which act as…
Polymer nanoparticles-preparations, applications and future insights: a concise review
Nanosized particles have appealing attributes, which have gotten impressive consideration in the last few decades. Polymeric nanoparticles (PNP)s are particles or particulate materials with size at least in the range of 10–100 nm in one…
Characterization and Optimization of Oral Solid Supersaturable Self-emulsifying Drug Delivery System…
Objective: This study aimed to prepare tablets containing solid supersaturable self-emulsifying drug delivery system (S-SEDD) of cilostazol for oral use.
Method: To improve drug dissolution and so bioavailability for cilostazol (calss II…
Spray coating of cellulose aerogel particles in a miniaturized spouted bed
Aim of this work is to apply protective and homogeneous shellac coating layers on the surface of hydrophilic open-pore cellulose aerogel particles with low densities ≤ 0.1 g/cm3 and high specific surface areas in the range of ~ 400–450 m2/g…
Effects of Transcutol P and Precirol ATO-5 on Percutaneous Absorption of Flutamide from Emulgels
Background: Flutamide is a non-steroidal anti-androgenic agent which is not only used in treating prostate cancer but also can be effective in some disorders such as androgenic alopecia and male pattern baldness. Several serious side…
Application of Design Space, Uncertainty, and Risk Profile Strategies to the Development and…
Background: Counterfeit medicines are an increasing scourge that are difficult to identify and they have become industrialized and widespread through highly organized illegal channels.
Objective: This research aims to develop a robust…