Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches: Potential for enhanced treatment of osteoporosis
Abstract
As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) are the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has the potential to overcome GI irritation by facilitating the transdermal delivery of BPs. This…
Application of Design Space, Uncertainty, and Risk Profile Strategies to the Development and…
Background: Counterfeit medicines are an increasing scourge that are difficult to identify and they have become industrialized and widespread through highly organized illegal channels.
Objective: This research aims to develop a robust…
The development and qualification of liquid adsorption chromatography for poloxamer 188…
Poloxamer 188 (P188) is formulated in proteinaceous therapeutics as an alternative surfactant to polysorbate because of its good chemical stability and surfactant properties, which enable interfacial protection, preventing visible and…
Effect of pH modifiers on the solubility, dissolution rate, and stability of telmisartan solid…
The aim of the current study was to investigate the dual effect of an amorphous solid dispersion generated by hot melt extrusion and the addition of pH modifiers on the solubility and stability of telmisartan. Hydroxypropyl methylcellulose…
Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester…
Background: The drug release of antiparkinsonian drugs is an important issue during the formulation process because proper release kinetics can help to reduce the off periods of Parkinson’s disease. A 2-factor, 3-level (32) full-factorial…
Preparation and characterization of Eudragit L 100-55/chitosan enteric nanoparticles containing…
Background and purpose: Omeprazole (OMP) is broadly used for the treatment of gastroesophageal reflux and other acid-related diseases. The current study aimed to prepare enteric-coated nanoparticles containing OMP to achieve a stable powder…
Orodispersible Film Loaded with Enterococcus faecium CRL183 Presents Anti-Candida albicans Biofilm…
Background: Probiotic bacteria have been emerging as a trustworthy choice for the prevention and treatment of Candida spp. infections. This study aimed to develop and characterize an orodispersible film (ODF) for delivering the potentially…
A Trusted Solutions Provider To Adress Poor Drug Solubility
THE DRUG SOLUBILITY SPECIALIST FOR SOLID DISPERSIONS, PARTICLE ENGINEERING AND SILICA TECHNOLOGIES
Almost half of currently marketed drug products, and around 90 % of those in clinical development are associated with poor drug solubility…
Development of a BCS Class II Drug Microemulsion for Oral Delivery: Design, Optimization, and…
Our work is aimed at exploring the composition and the properties of microemulsion (ME), as a drug delivery system, to enhance the permeability across the gastrointestinal (GI) barrier of fenofibrate, a BCS class II drug. It is a prodrug…
Tetrahydrocurcumin encapsulation in cyclodextrins for water solubility improvement: synthesis,…
The solubility of the scarcely water-soluble molecule tetrahydrocurcumin (THC), a promising curcumin derivative to be used as biopesticide, was enhanced through the formation of inclusion complexes with different cyclodextrins (CDs).…
Effects of humidity and glidants on the flowability of pharmaceutical excipients. An experimental…
Granular materials are part of the design, production and final products of different industrial sectors. Powder flowability is a major topic in manufacturing and transport as it is closely related to process feasibility. Nonetheless, the…
Media Partnership APV and Pharma Excipients
APV and Pharma Excipients have agreed on a media partnership, starting 1st of July 2021.
APV is the independent, international and interdisciplinary scientific organisation focusing on pharmaceutical technology and industrial pharmacy.…
Formulating better medicines for children – 13th EuPFI Conference 2021 virtual
22.09. - 23.09.2021 | online platform, Germany
Dear Colleagues,
The EUPFI is delighted to announce its 13th annual (virtual) scientific conference and excited to bring you some of the interesting presentations and sessions you were…
Investigating the Influence of Excipients on the Stability of Levothyroxine Sodium Pentahydrate
A range of tablet excipients were evaluated for their influence on the physical form and chemical stability of levothyroxine sodium pentahydrate (LSP; C15H10I4NNaO4·5H2O). LSP–excipient binary powder blends were stored under two conditions:…
Structural and thermal analysis of cannabidiol orodispersible formulation
Cannabidiol (CBD) is an alkaloid that can be found in the Cannabis species, currently used in United States of America under the name of Epidiolex®, which was approved by Food and Drug Administration (FDA) for seizures treatment. The…
Webinar Recording: Hot Melt Extrusion (HME) with Shin-Etsu, Leistritz and the St. Johns University
Hot Melt Extrusion is a well established technology used in ASDs. Besides the advantage of being a solvent free method some attributes of the API and polymer have to be considered like glass transition temperature and decomposition…
Biopharmaceutical and rheometric studies in the development of a gel composition with dimethindene…
Every year there is an increase in the number of cases of hypersensitivity to bites from various insects. A local allergic reaction to bites occurs within a few minutes and is accompanied by acute pain at the site of the bite, severe…
An ultrasonographic assisted investigation for the enhancement of duodenal/cecal motility of…
Gastrointestinal (GI) disorders affect millions of people and are considered a major cause of global morbidity. Mosapride citrate (MOS) is a prokinetic agent with antiemetic effect. The drug suffers from poor bioavailability that is induced…
Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to…
Background
Nutraceuticals often referred as medicinally or nutritionally functional foods has drawn extensive attention in recent years because of their wide array of pharmacological activities. It has been well established that the…
Influence of excipients in Protein a chromatography and virus inactivation
The purification of monoclonal antibodies and Fc fusion proteins consist of several unit operations operated commonly as a platform approach, starting with Protein A chromatography. The first capture step, the following low pH virus…
Potentially harmful excipients in neonatal medications: a multicenter nationwide observational study…
Background
A multicenter investigation of neonate exposure to potentially harmful excipients (PHEs) in neonatal intensive care units (NICUs) in Japan has not been conducted.
Methods
A multicenter nationwide observational study was…
The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In…
Laser radiation has been shown to be a promising approach for in situ amorphization, i.e., drug amorphization inside the final dosage form. Upon exposure to laser radiation, elevated temperatures in the compacts are obtained. At…
Structured edible lipid-based particle systems for oral drug-delivery
Oral administration is the most popular and patient-compliant route for drug delivery, though it raises great challenges due to the involvement of the gastro-intestine (GI) system and the drug bioavailability. Drug bioavailability is…
3D Printing of Dapagliflozin Containing Self-Nanoemulsifying Tablets: Formulation Design and In…
The 3D printing techniques have been explored extensively in recent years for pharmaceutical manufacturing and drug delivery applications. The current investigation aims to explore 3D printing for the design and development of a…
Nanostructured Valsartan Microparticles with Enhanced Bioavailability Produced by High-Throughput…
The high-throughput drying and encapsulation technique called electrospraying assisted by pressurized gas (EAPG) was used for the first time to produce nanostructured valsartan within microparticles of excipients. Valsartan, a poorly…
Assessment of a Once-Daily Controlled-Release Ibuprofen Matrix Tablets Prepared Using…
Introduction
Hydrophilic polymers that swell or dissolve in aqueous media can have the potential to prepare controlled/sustained dosage forms for weakly acidic, poorly soluble drugs.
Objective
The main objective of this study is to…
Solvent Emulsification Evaporation and Solvent Emulsification Diffusion Techniques for Nanoparticles
Nowadays, there has been an increased demand of nanoparticulate-based drug delivery as nanoparticles (NPs) generally give more advantages over the conventional drug carriers for targeting in various parameters like more drug encapsulation,…
The Development of Thin-film Freezing and Its Application to Improve Delivery of Biologics as Dry…
While the formulation of pharmaceuticals as liquids is common practice, powders are associated with enhanced stability, avoidance of the cold chain, lower dosing requirements, and more convenient administration. These are particularly…
The pourability of ARBOCEL® products!
JRS cellulose products come in various shapes and structures.
For their customers, it is not only essential, to receive excellent functionality in their applications, but also to understand how they can incorporate the fibers in their…
IPEC Europe Excipient Conference 2021
22.09. - 23.09.2021 | LIVE ONLINE, Germany
Dear Colleagues,
IPEC Europe and APV are delighted to invite you to our 9th annual conference on pharmaceutical excipients.
The conference will focus on regulatory topics relating to…
Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct…
In pharmaceutical manufacturing, the utmost aim is reliably producing high quality products. Simulation approaches allow virtual experiments of processes in the planning phase and the implementation of digital twins in operation. The…
Insights into the Control of Drug Release from Complex Immediate Release Formulations
The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release process,…
On-Demand webinar: Multiparticulates 7 – Next Generation ODTS with high dosed Multiparticulates
In this webinar Norbert Pöllinger and Tom West presented the unique opportunities offered by the combination of 3D printing and multiparticulates to achieve novel solutions in ODT application. They demonstrated how swallowing issues of high…
Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant
The emergence of multidrug resistance (MDR) in malignant tumors is the primary reason for invalid chemotherapy. Antitumor drugs are often adversely affected by the MDR of tumor cells. Treatments using conventional drugs, which have specific…
Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a…
Phenytoin is a low aqueous solubility antiepileptic drug, but its phosphate ester prodrug fosphenytoin is soluble, although less permeable. In a previous study, the intranasal administration of aqueous-based formulations of fosphenytoin led…