Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches: Potential for enhanced treatment of osteoporosis
Abstract
As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) are the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has the potential to overcome GI irritation by facilitating the transdermal delivery of BPs. This…
Formulation of Chewable Tablets Containing Carbamazepine-β-cyclodextrin Inclusion Complex and F-Melt…
Due to its low solubility, carbamazepine (CBZ) exhibits slow and incomplete release in the gastrointestinal tract and, hence, variable pharmacokinetics and pharmacodynamic effect. Lots of methods have been devised to improve its solubility,…
The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using…
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to…
Accelerating transdermal delivery of insulin by ginsenoside nanoparticles with unique permeability
Diabetes is a metabolic disease caused by insufficient insulin secretion, action or resistance, in which insulin plays an irreplaceable role in the its treatment. However, traditional administration of insulin requires continuous…
3D printed hollow microneedles array using stereolithography for efficient transdermal delivery of…
A 3D printed assembly of hollow microneedles (HMNs) array, conjoined with a reservoir void, was designed and additively manufactured using stereolithography (SLA) technology utilizing a proprietary class-I resin. The HMNs array was utilized…
Introduction to LUBRI-PREZ – the new Magnesium Stearate
Introduction
Lubricants play a critical role in the development process of tableting and capsule filling. For decades, magnesium stearate has been the most commonly used lubricant in pharmaceutical and nutraceutical tablet formulations,…
Shaping the Future of Formulation Development with Melt-based 3D Printing Technologies
Three-dimensional (3D) printing is a powerful technology that has wide-ranging applications, including many in the pharmaceutical industry. Among the approaches that are being explored in the production of pharmaceutical dosage forms…
Galenic Lab-on-a-Chip concept for lipid nanocapsules production
The continuous production of drug delivery systems assisted by microfluidics has drawn a growing interest because of the high reproducibility, low batch-to-batch variations, narrow and controlled particle size distributions and scale-up…
Titanium dioxide: no longer considered safe as feed additive
Now, Titanium dioxide can no longer be considered safe when used as an additive in animal feed, EFSA has concluded. The assessment by EFSA’s Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) follows the conclusion…
Antihypertensives’ Rock around the Clock
Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has…
Solubility Enhancement of Diclofenac Using Solid Dispersions
The phenomenon which gives rise to a homogenous system, formed by the dissolution of solute in a solvent is known as solubility. Low solubility is the limiting factor in formulation development. Diclofenac being BCS class II drug have low…
New Characterization Measures of Pore Shape and Connectivity Applied to Coatings used for Controlled…
Pore geometry characterization-methods are important tools for understanding how pore structure influences properties such as transport through a porous material. Bottlenecks can have a large influence on transport and related properties.…
Dual-Acting Zeta-Potential-Changing Micelles for Optimal Mucus Diffusion and Enhanced Cellular…
Context: Overcoming the intestinal mucosal barrier can be a challenge in drug delivery. Nanoemulsions with negative zeta potentials can effectively permeate the mucus layer, but those with positive zeta potentials are better taken up by…
Segmented intravaginal ring for the combination delivery of hydroxychloroquine and anti-CCR5 siRNA…
Vaginal drug delivery has been shown to be a promising strategy for the prevention of sexually transmitted infections. Therapy delivered at the site of infection has many advantages including improved therapeutic efficacy, reduction in…
Mucoadhesive and mucus-penetrating Interpolyelectrolyte complexes for nose-to-brain drug delivery
Nasal administration offers a possibility of delivering drugs to the brain. In the present work, nasal drug delivery systems were designed based on cationic Eudragit® EPO (EPO) and anionic Eudragit® L100–55 (L100–55) methacrylate…
Evaluation of solid carvedilol-loaded SMEDDS produced by the spray drying method and a study of…
In this study, various formulations of solidified carvedilol-loaded SMEDDS with high SMEDDS loading (up to 67% w/w) were produced with the spray drying process using various porous silica-based carriers. The process yield was improved with…
Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin…
Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) were recently developed. In the present study, the storage stability of CNL powders consisting of lyoprotectant (i.e. sucrose or…
Non-dispersive impact technology for powder flow characterization
This study developed a tester where the powder flow was characterized using a low sample mass (2 g) and impact instead of dispersion mechanism to mitigate test space constraint. An impact chamber was established where the test powder bed of…
TPLS as predictive platform for twin-screw wet granulation process and formulation development
In recent years, the interest in continuous manufacturing techniques, such as twin-screw wet granulation, has increased. However, the understanding of the influence of the combination of raw material properties and process settings upon the…
Improving the Bioavailability of Challenging APIs using Hot Melt Extrusion with Polyvinyl Alcohol
New molecular entities (NMEs) are becoming larger and more lipophilic and, as a result, less soluble. While approximately 40% of active pharmaceutical ingredients (APIs) currently on the market show poor solubility, it is estimated that…
Encapsulation of phenolic compounds within nano/microemulsion systems: A review
Phenolic compounds (phenolics) have received great attention in the food, pharmaceutical and nutraceutical industries due to their health-promoting attributes. However, their extensive use is limited mainly due to their poor water…
Dexamethasone-Loaded Nanostructured Lipid Carriers for the Treatment of Dry Eye Disease
Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation, discomfort and visual disturbance, and standard treatment…
Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly…
Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve the solubility of slowly dissolving drugs. A variety of pharmaceutically compatible additives using different emerging technology is used for preparing…
Pectin based multi-particulate carriers for colon-specific delivery of therapeutic agents
In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme-triggered release approach has several advantages over other approaches due to unique microbial ecosystem in the colon. Multiple-unit carriers…
Film-Forming Systems for Dermal Drug Delivery
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the…
Topical Nanoemulgel for the Treatment of Skin Cancer: Proof-of-Technology
The present study is a mechanistic validation of ‘proof-of-technology’ for the effective topical delivery of chrysin nanoemulgel for localized, efficient treatment of melanoma-affected skin.
Background: Currently available treatments for…
Hot-Melt Extrusion: a Roadmap for Product Development
Hot-melt extrusion has found extensive application as a feasible pharmaceutical technological option over recent years. HME applications include solubility enhancement, taste masking, and sustained drug release. As bioavailability…
Microfibrous cyclodextrin boosts flame retardancy of poly(lactic acid)
2-hydroxypropyl-β-cyclodextrin (HP-β-CD) microfibres with diameters ranging between 3-7 µm were prepared by aqueous solution based high-speed electrospinning (HSES) technique and then used as carbonising agent at 3 wt% loading besides…
A Review of Emerging Technologies Enabling Improved Solid Oral Dosage Form Manufacturing and…
Tablets are the most widely utilized solid oral dosage forms because of the advantages of self-administration, stability, ease of handling, transportation, and good patient compliance. Over time, extensive advances have been made in…
PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up
Nanomedicines based on poly(lactic-co-glycolic acid) (PLGA) carriers offer tremendous opportunities for biomedical research. Although several PLGA-based systems have already been approved by both the Food and Drug Administration (FDA) and…
Effects of Different Capsule Types for Oral Application of Active Substances – Investigations with…
1.1. Background: A capsule is a solid dosage form that delivers a defined dose of an active ingredient. Most capsules are made for oral application by mouth with subsequent swallowing. Capsule materials for the shell are not only of…
Polymer-mediated drug supersaturation – a spotlight on the interplay between phase-separated…
Hypothesis
Colloidal aggregation phenomena have been found responsible for the supersaturation of poorly water-soluble drugs, potentially leading to bioavailability enhancements. Unlike coarse precipitates, phase separation in the form…
Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of…
The current study evaluated the effect of location and amount of various superdisintegrants on the properties of tablets made by twin-screw melt granulation (TSMG). Sodium-croscarmellose (CCS), crospovidone (CPV), and sodium starch…
Diving into 3D (bio)printing: A revolutionary tool to customize the production of drug and…
The incorporation of 3D printing technologies in the pharmaceutical industry can revolutionize its R&D, by providing a simple and rapid method to produce tailored one-off batches, each with customized dosages, different compounds,…
The influence of moisture on the storage stability of co-amorphous systems
Co-amorphization has been utilized to improve the physical stability of the respective neat amorphous drugs. However, physical stability of co-amorphous systems is mostly investigated under dry conditions, leaving the potential influence of…