Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches: Potential for enhanced treatment of osteoporosis
Abstract
As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) are the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has the potential to overcome GI irritation by facilitating the transdermal delivery of BPs. This…
Predictive Approach to Understand and Eliminate Tablet Breakage During Film Coating
Pharmaceutical tablets can be susceptible to damage such as edge chipping or erosion of the core during the tablet coating process. The intersection of certain process parameters, equipment design, and tablet properties may induce more…
Development of Gelucire® 48/16 and TPGS Mixed Micelles and Its Pellet Formulation by Extrusion…
The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption. Herein, the study describes formulation of curcumin-loaded mixed micelles of Gelucire® 48/16 and TPGS for its dissolution…
Enhanced Eradication of Mucin-Embedded Bacterial Biofilm by Locally Delivered Antibiotics in…
Bacterial biofilm-related infections are difficult to eradicate and require repeated treatments with high doses of antibiotics. Thus, there is an urgent need for new treatment strategies that minimize the use of antibiotics while enhancing…
Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance
Platinum drugs are commonly used in cancer therapy, but their therapeutic outcomes have been significantly compromised by the drug resistance of cancer cells. To this end, intensive efforts have been made to develop nanoparticle-based…
Recent Advancement of Biopolymers and Their Potential Biomedical Applications
Recently, the advantages of biopolymers over conventional plastic polymers are unprecedented, provided that they are used in situations in which they raise the functionality and generate extra benefits for human life. Therefore, biopolymers…
Fabrication and Characterization of Fast-Dissolving Films Containing Escitalopram/Quetiapine for the…
Major depressive disorder (MMD) is a leading cause of disability worldwide. Approximately one-third of patients with MDD fail to achieve response or remission leading to treatment-resistant depression (TRD). One of the psychopharmacological…
New Opportunities for Oral Sustained Release Formulations with Polyvinyl Alcohol
Achieving the appropriate release kinetics for an active pharmaceutical ingredient (API) is essential to ensure success of the therapeutic. For example, for sustained release formulations, a consistent API dose over a prolonged period…
Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier…
Purpose
Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle…
Physico-chemical Modification of Gelatine for the Improvement of 3D Printability of Oxidized…
This work explored 3D bioplotting to mimic the intrinsic hierarchical structure of natural articular cartilage. Alginate dialdehyde-gelatine (ADA-GEL) was used as a hydrogel ink to create hierarchically ordered scaffolds. In comparison to…
Real-time Monitoring of Powder Mass Flowrates for Plant-wide Control of a Continuous Direct…
While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet manufacturing, in continuous operation, it is an important additional critical process…
Three-dimensional printing of tablets – a potential approach to on-clinical-site extemporaneous…
The oral route is the most common form of drug administration, being a safe and convenient, particularly for solid oral dosage forms. Current large-scale manufacturing techniques mostly result in fixed dose units and allow a limited choice…
Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared…
Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several studies, however,…
Enabling the direct compression of metformin hydrochloride through QESD crystallization
Metformin hydrochloride is a drug used in the treatment of type 2 diabetes. It shows very poor flowability and agglomeration under storage so that a direct compression of the material into tablets has not yet been successfully realized. In…
Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide
Purpose
Successful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane permeability. While lipid-based formulations (LBF) have the potential to overcome these…
Exploring the Myth of Inert Excipients
Introduction
Stable active pharmaceutical ingredients (APIs) represent a critical success factor for drug formulation for four main reasons.
Firstly, the potential instability of APIs can represent a critical threat to patient safety.…
Development and evaluation of a composite dosage form containing desmopressin acetate for buccal…
Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP accelerated a shift to alternative routes of administration like nasal and…
3D-printed construct from hybrid suspension as spatially and temporally controlled protein delivery…
Protein delivery systems have been extensively applied in controlled releasing of protein or polypeptides for therapeutic treatment or tissue regeneration. While 3D printing technology shows great promise in novel dosage form with tailoring…
Understanding the Impact of Protein–Excipient Interactions on Physical Stability of Spray-Dried…
Mannitol, leucine, and trehalose have been widely used in spray-dried formulations, especially for inhalation formulations. The individual contribution of these excipients on protein physical stability in spray-dried solids was studied here…
Anti-counterfeiting protection, personalized medicines − development of 2D identification methods…
Counterfeiting of the products for healing is as old as trading, and it is difficult to quantify the magnitude of the problem. It is known that substandard and/or falsified (SF) medicines are a growing global threat to health, and they…
Formulation and evaluation of sustained release pellets of lornoxicam
Objective: The aim of study was to develop sustained release pellets of lornoxicam using Eudragit RLPO and Eudragit RSPO to reduce the dosing frequency.
Methods: The sustained release pellets of lornoxicam were prepared by extrusion –…
Progress in the study of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) reversing…
Currently, multidrug resistance (MDR) is one of the major reasons for failure in clinical cancer chemotherapy. Overexpression of the ATP binding cassette (ABC) transporter P-glycoprotein (P-gp), which significantly increases the efflux of…
Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in…
In this study metronidazole drug was encapsulated by hydroxypropyl methylcellulose and polyvinylpyrrolidone polymers from solutions using nano spray drying technology. The influence of the process parameters and formulation variables were…
Do we need to replace Titanium Dioxide in Pharmaceutical Formulations?
Update from October 7th: News on EU commission's decision:
On what have the member states voted on 7 October and what are the next steps?
"The Member States have expressed a favourable opinion, in the context of a Standing Committee on…
Solid lipid nanoparticles for hydrophilic drugs
Hydrophilic drugs are proficient therapeutic agents however, delivery of these drugs is a difficult task. Hence, developing an efficient drug delivery system may require a multipronged approach. Colloidal drug delivery systems such as…
On the relationship between blend state and dispersibility of adhesive mixtures containing active…
The objectives of this investigation were to study the evolution in blend state of adhesive mixtures containing the active pharmaceutical ingredients (APIs) salbutamol, budesonide and AZD5423 and to study the relationship between blend…
ZoomLab™: Digitally guiding dosage form and formulation for improved solubility
Poorly soluble drugs for oral administration present unique formulation challenges, particularly during early development. Various formulation approaches are available, and several aspects must be evaluated in order to identify which choice…
The investigation of mRNA vaccines formulated in liposomes administrated in multiple routes against…
COVID-19 pandemic has resulted in an unprecedented global public health crisis. It is obvious that SARS-CoV-2 vaccine is needed to control the global COVID-19 public health crisis. Since obvious advantages including fast manufacturing…
Influence of process and formulation parameters on the preparation of solid lipid nanoparticles by…
A promising strategy to formulate poorly water-soluble active pharmaceutical ingredients (APIs) is the application of these substances in solid lipid nanoparticles. These drug carrier systems are commonly prepared by high-pressure…
Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness,…
The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating…
Phase behavior of ASDs based on hydroxypropyl cellulose
Novel polymeric carriers for amorphous solid dispersions (ASDs) are highly demanded in pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates. Besides established polymer candidates, hydroxypropyl…
Enabling formulations of aprepitant: in vitro and in vivo comparison of nanocrystalline, amorphous…
A deep eutectic solvent (DES) is a eutectic system consisting of hydrogen bond donor and acceptor has been suggested as a promising formulation strategy for poorly soluble drugs. A DES consisting of choline chloride and levulinic acid in a…
Towards predicting the product quality in hot-melt extrusion: Pilot plant scale extrusion
Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality. To this end, we studied the influence of…
Drug crystal growth in ternary amorphous solid dispersions: Effect of surfactants and polymeric…
The present study evaluates the crystal growth rate of amorphous drugs when dispersed in different ternary polymeric amorphous solid dispersions (ASDs) in the presence of surfactants. Specifically, ternary ASDs of aprepitant (APT, selected…
Fine powder of lipid microparticles – spray drying process development and optimization
Objectives: Performed studies were focused on developing spray drying technique for aqueous dispersion of solid lipid microparticles (SLM) by selecting appropriate process parameters and assessing their impact on the process and…