Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches: Potential for enhanced treatment of osteoporosis
Abstract
As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) are the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has the potential to overcome GI irritation by facilitating the transdermal delivery of BPs. This…
Scalable Production of Lipid Nanoparticles Containing Amphotericin B
Lipid-based formulations have been developed to improve stability profiles, tolerability, and toxicity profiles of small molecule drugs. However, manufacture of such formulations involving lipophilic compounds can be labor-intensive and…
Emulsification Speed of Amphiphilic Starches
Amphiphilic starches (sodium octenylsuccinate starches) are a well‐known emulsifier for various food and pharma applications. Typical applications are the encapsulation of lipophilic compounds such as vitamins and other micronutrients or…
Formulation development and evaluation of nimesulide transdermal gel patch system
The objective was to develop a reservoir-type nimesulide gel patch for controlled drug delivery and avoid the gastrointestinal adverse effects associated with the oral delivery of nimesulide. Six patch formulations of nimesulide gel…
Webinar series: Advances In Amorphous Solid Dispersion Technologies
In this series of webinars we will discuss the latest developments in the fields of amorphous solid dispersion (ASD) focusing on Excipient Key Attributes linked to the most popular technologies: Hot Melt Extrusion (HME), Spray Drying and…
Direct surface modification of mesoporous silica nanoparticles by DBD plasma as a green approach to…
This paper deals with uniformly surface modification of mesoporous silica nanoparticles by applying dielectric barrier discharge (DBD) plasma as an energy-efficient and green approach. First, the mesoporous silica nanoparticles were…
Functionality and Acceptance of the EsoCap System – A Novel Film-Based Drug Delivery…
There are no methods for specific local application of active substances to the mucosa of the esophagus to treat eosinophilic esophagitis or other esophageal diseases. This publication describes the principal in vivo functionality and…
A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets
Developing solid oral drug products with good content uniformity (CU) at low doses is challenging; this challenge further aggravates when the tablet size decreases from a conventional tablet to a micro/mini-tablet (1.2 – 3mm…
Leucine as an excipient in spray dried powder for inhalation
Leucine is a promising excipient with several applications in the development of inhalable spray-dried powder of high- and low-dose drugs. The addition of leucine has exhibited significant enhancing effects on the aerosolization and…
Nanostructured lipid carriers enhances the safety profile of tretinoin: in vitro and healthy human…
Aim: To enhance the tretinoin (TRE) safety profile through the encapsulation in nanostructured lipid carriers (NLC).
Materials & methods: NLC-TRE was developed using a 23 experimental factorial design, characterized (HPLC, dynamic…
Rheological properties of cellulosic thickeners in hydro-alcoholic media: the science behind the…
Cellulosic-based thickeners are commonly used in the preparation of hydro-alcoholic hand sanitisers. Yet, little is known about the behaviour of these polymeric dispersions in hydro-alcoholic mixtures. Here, we studied the dispersion…
Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100…
A novel nanofiber insert was prepared with a modified electrospinning method to enhance the ocular residence time of ofloxacin (OFX) and to provide a sustained release pattern by covering hydrophilic polymers, chitosan/polyvinyl alcohol…
Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process…
Lyophilization of nanoparticle (NP) suspensions is a promising technology to improve stability, especially during long-term storage, and offers new routes of administration in solid state. Although considered as a gentle drying process,…
Exploring the Role of Surfactants in Enhancing Drug Release from Amorphous Solid Dispersions at…
To reduce the dosage size of amorphous solid dispersion (ASD)-based formulations, it is of interest to devise formulation strategies that allow increased drug loading (DL) without compromising dissolution performance. The aim of this study…
Mixed Pluronic – Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics…
In this work, novel polymeric mixed micelles from Pluronic F127 and Cremophor EL were investigated as drug delivery systems for Norfloxacin as model antibiotic drug. The optimal molar ratio of surfactants was determined, in order to…
Impact of hydrophilic binders on stability of lipid-based sustained release matrices of quetiapine…
Dose dumping is the major drawback of sustained release (SR) matrices. The current research aimed to develop the stable lipid-based SR matrices of quetiapine fumarate (QTF) using GeleolTM (glyceryl monostearate; GMS) as the lipid matrix…
The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose
It is necessary to prepare porous lactose in order to improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels in…
Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an…
Biotherapeutic-loaded injectable hydrogels as a synergistic strategy to support myocardial repair…
Myocardial infarction (MI) has been considered as the leading cause of cardiovascular-related deaths worldwide. Although traditional therapeutic agents including various bioactive species such as growth factors, stem cells, and nucleic…
Development of ketorolac tromethamine loaded microemulsion for topical delivery using D-optimal…
Aim of the present study was to evaluate the potential of microemulsions for the transdermal delivery of ketorolac tromethamine. The pseudo ternary phase diagram, 3 D Optimal mixture design was used to develop the microemulsion of desired…
Heterologous vaccine interventions: boosting immunity against future pandemics
While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens. The…
GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells
Abstract:
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR)…
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and have shown promise for vaccine applications. Yet there are no published reports detailing how LNP biophysical properties can impact vaccine performance.…
Efficacy of topical risedronate and risedronate – Eudragit E complex in a model of cutaneous…
An efficacious topical treatment for cutaneous leishmaniasis (CL) is highly desirable but still an ongoing challenge. Systemic risedronate (Ris) has been reported to have anti-leishmanial properties and Eudragit EPO (EuE) has shown in vitro…
Development of a Nanocrystal Formulation of a Low Melting Point API Following a Quality by Design…
Preparation of nanocrystal formulations by wet media milling and spray-drying is a reliable technique to enhance dissolution and ameliorate absorption limitations of poorly soluble BCS II drugs. However, when thermosensitive compositions…
Preparation of Insoluble Matrix Tablets of Theacrine
Background: Theacrine (1,3,7,9-tetramethyluric acid, TC) is a purine alkaloid rich in the tender leaves of an unusual Chinese tea known as Kucha. TC possessed diverse pharmacological activity including antioxidative, anti-inflammatory,…
Polymeric and Lipid Nanoparticles: Which Applications in Pediatrics?
This review aims to provide the state of the art on polymeric and lipid nanoparticles, used or suggested to approach pediatric diseases’ problems and needs, and to inspire new researches in this field. Several drugs are currently not…
Calcium Carbonate as Functional Filler in Polyamide 12 – Manipulation of the Thermal and…
Adjusting the thermal response properties of a polymeric compound can significantly improve the usability in a selective laser-sintering process. As previously shown, combining a precise amount of coarse and narrow size distribution fine…
Electrostatic deposition assisted preparation, characterization and evaluation of chrysin liposomes…
Chrysin (CHR), a flavone found in multiple vegetables, fruits and mushrooms has been explored so far as a neurotropic, anti-inflammatory and anti-cancer biomolecule. Despite the stated therapeutic potential, low solubility and…
The bitterness masking effect of β-cyclodextrin in the formulation of ODTs using Granfiller D
CycloLab Cyclodextrin R&D Laboratory, Ltd., Hungary and Daicel Corporation have jointly published a white paper on the bitterness masking effect of β-cyclodextrin (β-CD) in the formulation of orally disintegrating tablets (ODTs) using…
Novel polyester-based thermoplastic elastomers for 3D-printed long-acting drug delivery applications
To improve patient compliance and personalised drug delivery, long-acting drug delivery devices (LADDDs), such as implants and inserts, greatly benefit from a customisation in their shape through the emerging 3D-printing technology, since…
Low-in-nanoparticulate-impurities sucrose for biopharmaceutical formulations
Purpose
Nanoparticle impurities (NPIs) with a size of 100–300 nm have recently been discovered in pharmaceutical-grade sucrose (Weinbuch et al., 2015). These can lead to false analytical results, as they mimic protein aggregates and can…
Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel…
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules. For comparative purposes, corresponding…
Residence Time and Mixing Capacity of a Rotary Tablet Press Feed Frame
Most rotary tablet presses contain a feed frame to provide a continuous powder flow and to feed powder into the dies. The wide residence time distribution (RTD) of these feed frames is problematic, because it negatively affects material…
A Dry Powder Platform for Nose-To-Brain Delivery of Dexamethasone: Formulation Development and Nasal…
Nasal route of administration offers a unique opportunity of brain targeted drug delivery via olfactory and trigeminal pathway, providing effective CNS concentrations at lower doses and lower risk for adverse reactions compared to systemic…