Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
A Dry Powder Platform for Nose-To-Brain Delivery of Dexamethasone: Formulation Development and Nasal…
Nasal route of administration offers a unique opportunity of brain targeted drug delivery via olfactory and trigeminal pathway, providing effective CNS concentrations at lower doses and lower risk for adverse reactions compared to systemic…
Investigation on Hot Melt Extrusion and Prediction on 3D Printability of Pharmaceutical Grade…
The development of printable filaments has been identified as a critical aspect for the processing of pharmaceutical grade polymers and the fabrication of oral solid dosage forms. In this study a range of plain and drug loaded polymers were…
Effects of humidity and glidants on the flowability of pharmaceutical excipients. An experimental…
Granular materials are part of the design, production and final products of different industrial sectors. Powder flowability is a major topic in manufacturing and transport as it is closely related to process feasibility. Nonetheless, the…
Multiparticulates – modern oral drug products for our society; Part 6: DoE case studies in QbD…
In this webinar, Norbert Pöllinger presented a number of case studies showing how the pharmaceutical quality and processing times and cost of multiparticulate manufacturing processes can be optimized. DoE’s are an important tool for product…
Screening pharmaceutical excipient powders for use in commercial 3D binder jetting printers
Binder jetting is an additive manufacturing technique that creates three-dimensional constructs from a powder feedstock. It is used by several industries, including pharmaceuticals. This additive approach to manufacture provides several…
In Vitro and In Vivo Biological Assessment of Dual Drug-Loaded Coaxial Nanofibers for the Treatment…
The treatment of corneal abrasion currently involves the topical administration of antibiotics, with moxifloxacin HCl (0.5% w/v) eye drops being one of the most widely used treatments. Our previous work (Tawfik et al., 2020) involved the…
Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug…
Biodegradable polymeric microneedle arrays (BPMNAs) could be explored as potential devices for transdermal drug delivery, which can provide a painless and safe drug delivery method. BPMNAs could also provide high drug-loading capacity and…
Transdermal drug delivery systems for fighting common viral infectious diseases
Transdermal drug delivery systems (TDDS) have many advantages and represent an excellent alternative to oral delivery and hypodermic injections. TDDS are more convenient and less invasive tools for disease and viral infection treatment,…
Effect of Poly(trehalose methacrylate) Molecular Weight and Concentration on the Stability and…
Instability to storage and shipping conditions and injection administration remain major challenges in treating chronic conditions with biopharmaceuticals. Herein, formulations of poly(trehalose methacrylate) (pTrMA) are successfully…
Ocular Distribution of Papaverine Using Non-aqueous Vehicles
Papaverine, a poorly soluble opium alkaloid, has recently been shown to reduce retinal inflammation due to which it may have therapeutic application in the management of Leber’s hereditary optic neuropathy. In this study, papaverine…
Formulation of Gelucire®-Based Solid Dispersions of Atorvastatin Calcium: In Vitro Dissolution and…
Atorvastatin (ATV) is a poorly water-soluble drug that exhibits poor oral bioavailability. Therefore, present research was designed to develop ATV solid dispersions (SDs) to enhance the solubility, drug release, and oral bioavailability.…
Chlorhexidine Mucoadhesive Buccal Tablets: The Impact of Formulation Design on Drug Delivery and…
Oropharyngeal candidiasis (OPC) is a mucosal infection caused by Candida spp., and it is common among the immunocompromised. This condition is mainly treated using oral antifungals. Chlorhexidine (CHD) is a fungicidal and is available as a…
Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization
This research aimed to develop a novel drug delivery system to improve treatment of skin disorders. The system is comprised of a Carbopol 980-based nanoemulgel (NE-gel) containing a desonide (DES; 0.05%, w/w) nanoemulsion (NE),…
Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in…
Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous…
Does Magnesium Stearate influence the electrical charge of lactose powder?
GranuTools was present in 2 sessions at the #PBPWorldMeeting. Granutools highlighted the dramatic influence of electrostatic charges in pharmaceutical processes. The GranuCharge, developed by GranuTools, can help the industry to measure the…
Mesoporous silica: a solution for amorphous stabilization of poor glass formers
Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer based amorphous formulations manufactured by spray…
Translating 3D printed pharmaceuticals: From hype to real-world clinical applications
Three-dimensional (3D) printing is a revolutionary technology that is disrupting pharmaceutical development by enabling the production of personalised printlets (3D printed drug products) on demand. By creating small batches of dose…
JRS PHARMA Introduces LUBRI-PREZ Magnesium Stearate into its Excipients Portfolio
Rosenberg, Germany / Vadodara, India - JRS PHARMA is pleased to announce a new addition to its comprehensive excipients portfolio, LUBRI-PREZ Magnesium Stearate. Magnesium stearate is one of the most commonly used excipient lubricants in…
Brucine-loaded transliposomes nanogel for topical delivery in skin cancer: statistical optimization,…
The aim of the present study was to develop, optimize brucine-loaded transliposomes (BRC-TL) formulation for dermal delivery of brucine for skin cancer. The BRC-TL formulations were evaluated for vesicle size, entrapment efficiency, and in…
Characterizing powders rheology and triboeletric properties for continuous manufacturing…
GranuTools was present in 2 sessions at the #PBP World Meeting. In the first session, GranuTools highlighted the importance of investigating the influence of the processing conditions on the rheology and flow properties of powders. The…
Inulin-based carriers for colon drug targeting
Inulin is a heterogeneous green polysaccharide obtained from natural sources. It is found in a variety of regularly eaten vegetables, fruits, cereals, and in their roots and rhizomes including onion, leek, wheat, garlic, dahlia, asparagus,…
Enhancement of cytotoxicity of diallyl disulfide toward colon cancer by Eudragit S100/PLGA…
According to WHO cancer is the second leading cause of death globally, amounting to about 1 in 6 deaths. Among these, colon cancer is the third leading cause of mortalities worldwide. Current measures for cancer treatment: chemotherapy,…
EUDRACAP™ – The new platform of easy to handle capsules from Evonik
READY-TO-FILL COATED CAPSULES FOR FAST DRUG DEVELOPMENT
For pharmaceutical companies who are bringing a new oral drug product to market, the selection of the right coated capsule formulation can help to boost functional performance and…
The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of…
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation.…
Imerys opens its extended European Technology Center for performance minerals in Toulouse, France
Geared towards our clients' operational requirements, the idea behind this investment is to speed up the launch of new products to meet the emerging needs of our key markets.
The 2500m² Toulouse Technology Center hosts 50 experts and…
Assessment of Mini-Tablets Coating Uniformity as a Function of Fluid Bed Coater Inlet Conditions
This study concerned the quality of mini-tablets’ coating uniformity obtained by either the bottom spray chamber with a classical Wurster distributor (CW) or a swirl distributor (SW). Mini-tablets with a diameter of 2.0, 2.5, and 3.0 mm…
Microwave-induced in situ drug amorphization using a mixture of polyethylene glycol and…
The use of a mixture of polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) was investigated for microwave-induced in situ amorphization of celecoxib (CCX) inside compacts. Such amorphization requires the presence of a dipolar…
Evaluation of lactose based 3D powder bed printed pharmaceutical drug product tablets
It is key to understand powder blend characteristics in relation to tablet characteristics when using pharmaceutical 3D printing, in order to obtain 3D powder bed printed tablets that comply with the pharmaceutical specifications. There is…
Amorphous Solid Dispersions Containing Residual Crystallinity: Competition Between Dissolution and…
Crystallinity in an amorphous solid dispersion (ASD) may negatively impact dissolution performance by causing lost solubility advantage and/or seeding crystal growth leading to desupersaturation. The goal of the study was to evaluate…
Oral jelly of metformin hydrochloride – Formulation development using Design of Experiments and…
Metformin hydrochloride is an antihyperglycemic drug, for treatment of type 2 diabetes. The therapeutic dose range is 250 mg–1000 mg in immediate release form. Due to bulky nature of the tablets, there may be difficulty in swallowing to…
Particle agglomeration analysis using PATVIS APA and deep learning
Introduction: Pharmaceutical, chemical, cosmetic, food, and other industries utilize various processes to modify particle properties, where agglomeration of particles occurs either as an accurately controlled process or as an undesired…
Calculation of Solubility Parameters is now available in ZoomLab™
Solubility parameters allow rapid screening for suitable excipients such as solvents or polymers that are expected to interact strongly with a given active ingredient. ZoomLab™’s “Solubility Parameter Calculation” module allows for…
Harnessing Artificial Intelligence for the Next Generation of 3D Printed Medicines
Artificial intelligence (AI) is redefining how we exist in the world. In almost every sector of society, AI is performing tasks with super-human speed and intellect; from the prediction of stock market trends to driverless vehicles,…
In vivo drug delivery via contact lenses: The current state of the field from origins to present
Over the past half century, contact lenses have been investigated for their potential as drug delivery devices for ocular therapeutics. Hundreds of studies have been published in the pursuit of the most effective and efficient release…