Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
SEPITRAP™ offers new possibilities for formulation and improving the bioavailability of active…
Description
SEPITRAP™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.…
See the Rotative Tablet Press Machine CPR-22 from Bonapace
In the realm of pharmaceutical manufacturing, efficiency and precision are paramount. The CPR-22 tablet press from Bonapace emerges as a beacon of innovation, offering a cutting-edge solution tailored to the unique demands of the industry.…
Fabrication of Orally Fast Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze…
Abstract
Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery
and to also enhance patient convenience.
Methods: Orally fast disintegrating wafer tablets containing cannabis…
Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood…
Due to its versatility in formulation and manufacturing, self-emulsifying drug delivery systems (SEDDS) can be used to design parenteral formulations. Therefore, it is necessary to understand the effects of excipients on the behavior of…
Development of Lipid-based SEDDS Using Digestion Products of Long-chain Triglyceride for High Drug…
A self-emulsifying drug delivery system (SEDDS) containing long chain lipid digestion products (LDP) and surfactants was developed to increase solubility of two model weakly basic drugs, cinnarizine and ritonavir, in the formulation. A…
Chrono-tailored drug delivery systems: recent advances and future directions
Abstract
Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by…
Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate…
Abstract
Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute manic episodes. QTF can also be used as an adjunctive treatment for major depressive disorders. QTF oral bioavailability is limited due to its…
Equivalence assessment of creams with quali-quantitative differences in light of the EMA and FDA…
Abstract
EMA and FDA are upgrading guidelines on assessing the quality and the equivalence of topically applied drug products for developing copies of originator products and supporting post-marketing variations. For topical products…
High loading of lipophilic compounds in mesoporous silica for improved solubility and dissolution…
Loading poorly soluble active pharmaceutical ingredients (API) into mesoporous silica can enable API stabilization in non-crystalline form, which leads to improved dissolution. This is particularly beneficial for highly lipophilic APIs (log…
Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a…
As a high number of active pharmaceutical ingredients (APIs) under development belong to BCS classes II and IV, the need for improving bioavailability is critical. A powerful approach is the use of lipid-based formulations (LBFs) that…
Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Abstract
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we…
Application of 3D printing technology for the development of dose adjustable geriatric and pediatric…
Abstract
Developing safe and effective formulations for the geriatric and pediatric population is a challenging task due to issues of swallowability and palatability. The lack of standardized procedures for pediatric formulations further…
Formulation development of methotrexate lipid-based nanogel for treatment of skin cancer
Skin cancer (SC) represents a prevalent malignancy worldwide, characterized by its high drug resistance and limited therapeutic efficacy with conventional treatments. Nanoparticles have emerged as promising vehicles for targeted drug…
Interplay of Drug–Polymer Interactions and Release Performance for HPMCAS-Based Amorphous Solid…
The interplay between drug and polymer chemistry and its impact on drug release from an amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release rates of several drugs of diverse chemistry from hydroxypropyl…
The Effect of Microcrystalline Cellulose–CaHPO4 Mixtures in Different Volume Ratios on the…
Abstract
Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable…
Mirtazapine loaded polymeric micelles for rapid release tablet: A novel formulation – In vitro…
Major depression is a prevalent disorder characterized by sadness, lack of interest or pleasure, interrupted sleep or food, and impaired concentration. Mirtazapine (MTZ), a tetracyclic antidepressant drug, is commonly used to treat moderate…
Development of a New Bioequivalent Omeprazole Product
Abstract
Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary…
High Quality from Source to Final Product – Refined Olive Oil IV
ADMs Refined Olive Oil IV is a highly purified olive oil fully compliant with the European Pharmacopoeia (1456) and United States Pharmacopeia/National Formulary (USP/NF) monographs and general notices intended for use in the manufacturing…
The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid…
Abstract
Amorphous solid dispersion (ASD) is an effective approach for enhancing the solubility, dissolution, and bioavailability of poorly water-soluble drugs. However, these metastable forms can transform into more thermodynamically…
Assessing Abuse-Deterrent formulations utilizing Ion-Exchange resin complexation processed via…
Opioid misuse is a public health crisis in the United States. In response, the FDA has approved drug products with abuse-deterrent features to reduce the risk of prescription opioid abuse. Abuse-deterrent formulations (ADFs) typically…
See the Galenic Laboratory at Armor Pharma
Since 2020, Armor Pharma has invested in a state-of-the-art galenic laboratory, reinforcing their expertise as a pharmaceutical lactose supplier.
Watch the new video State-of-the-art Galenic Laboratory by Armor Pharma below:…
Novel inhalable powder formulation of pirfenidone with sustained release properties to improve…
Abstract
The aim of this study was to develop a new respirable powder (RP) formulation of pirfenidone (PFD) with sustained release properties to ameliorate the pharmacokinetic drawbacks of the previously-developed PFD-RP on rapid…
3D-Printed Lipid Mesophases for the Treatment of Chronic Liver Disease
Abstract
Although lipid-based formulations are an attractive approach for enhancing the oral bioavailability of lipophilic drugs, their addition into solid oral dosage forms has been proven challenging due to their high viscosity and…
Pharma Acetates – by Kerry
Focused on quality for better health
Pharma acetates are used across a range of pharma applications that require a focus on quality control and product excellence. Using pharma-grade raw materials, our range of Niacet acetates are…
A review on natural biopolymers in external drug delivery systems for wound healing and atopic…
Abstract
Despite the advantages of topical administration in the treatment of skin diseases, current marketed preparations face the challenge of the skin's barrier effect, leading to low therapeutic effectiveness and undesirable side…
Self-microemulsifying system of an ethanolic extract of Heliopsis longipes root for enhanced…
Abstract
Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts…
Lamellar double hydroxides as pharmaceutical excipients: a compatibility study
Lamellar double hydroxides (LDH) are a class of inorganic materials widely used as pharmaceutical ingredients. However, their use as excipients and mainly as drug carriers lacks specific research in pharmaceutical technology, as there are…
Open-source extrusion 3D bioprinters: Trends and recommendations
Three-dimensional (3D) extrusion bioprinting, an additive manufacturing process that hybridizes traditional thermoplastic 3D printing technology with the latest developments in tissue engineering, is a promising tool for engineering…
Fabrication of suppository shells via hot-melt extrusion paired with fused deposition modeling 3D…
Three-dimensional (3D) printing is a potential technique for developing personalized medicines. Among its applications, mold manufacturing in industrial 3D printing stands out, especially for creating complex structures. This capability has…
Chitosan and Anionic Solubility Enhancer Sulfobutylether-β-Cyclodextrin-Based Nanoparticles as…
Abstract
Cataract surgery interventions are constantly increasing, particularly among adult and elderly patients. This type of surgery can lead to inflammatory states of the ocular anterior segment (AS), usually healed via postoperative…
Development of a Eudragit-based hydrogel for the controlled release of hydrophobic and hydrophilic…
Wounds are a daily occurrence that requires wound dressings to prevent infections and promote healing. Various wound dressing types are used in clinics to prevent infections and promote healing, and dressings vary with the wound's severity…
Nanoformulation for Enhanced Drug Delivery and Better Patient Compliance
The increasing occurrence of highly potent or frequent-administration therapies in the drug development pipeline means that the low solubility of drugs is becoming a potential bottleneck for pharmaceutical formulators. This not only makes…
Polymeric microneedles for the eye: An overview of advances and ocular applications for minimally…
Abstract
Ocular drug delivery is challenging due to the presence of tissue barriers and clearance mechanisms. Most widely used topical formulations need frequent application because of poor permeability, short retention, and low…
Current State of Minitablet Product Design: A Review
Abstract
Interest in minitablets (MTs) has grown exponentially over the last 20 years and especially the last decade, as evidenced by the number of publications cited in Scopus and PubMed. MTs offer significant opportunities for…