Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications
Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost-effectiveness, solvent-free nature, and continuous manufacturing…
QbD Enabled Optimization of Solvent Shifting Method for Fabrication of PLGA Based Nanoparticles for…
The key objective of the current research was to fabricate and optimize Capecitabine loaded PLGA based nanoparticles (NPs) by enabling Quality by Design (QbD) approach for enhancing antitumor activity by promising delivery of the drug at…
Functionalized carbon nano onion as a novel drug delivery system for brain targeting
Pharmacologically active compounds having poor permeability through several physiological barriers often limits their application. New age therapeutics such as peptides or nucleic acid-based agents are promising but their targeted delivery…
Decision Support for Solubilization is now available in ZoomLab™
If you are working with poorly water-soluble APIs and wondering about effective formulation strategies - this 2.4 version update to ZoomLab™ by BASF is truly revolutionary.
Calculate Hansen SOL parameters for any APIs
Discover…
Natural gum polysaccharides as efficient tissue engineering and drug delivery biopolymers
The usage of plant origin natural gum polysaccharides in various biomedical applications is steadily rising in recent years because of their peculiar properties like biocompatibility, biodegradability, cytocompatibility and with no…
Systematically designed chitosan-coated solid lipid nanoparticles of ferulic acid for effective…
Ferulic acid (FA) is a ubiquitous natural plant bioactive with distinctive promise in neurodegenerative disorders. However, its therapeutic efficacy gets compromised owing to its poor aqueous solubility, inadequate permeability across…
Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation
The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of…
TPGS and chondroitin sulfate dual-modified lipid-albumin nanosystem for targeted delivery of…
Multidrug resistance (MDR) remains the primary issue leading to the failure of chemotherapy. In this study, a d-α-tocopherol polyethylene 1000 glycol succinate (TPGS) and chondroitin sulfate (CS) dual-modified lipid-albumin nanosystem was…
Seppic injectable polysorbates Montanox™ 80 PPI and Montanox™ 20 PPI are now compliant in the…
Montanox™ 80 PPI and Montanox™ 20 PPI, ingredients developed and produced by Seppic, comply with the current Chinese pharmacopoeia and will be marketed in China from May 2021.
As a supplier of specialty healthcare ingredients, Seppic is…
GMP trainer Dominic Parry talked with us about his experiences and the new normal of virtual GMP…
Due to the comprehensive changes in the way trainings are done since the pandemic, we did an interview with the GMP trainer Dominic Parry from Inspired Pharma Training! Before the pandemic, all courses were held as face-to-face sessions,…
Stability and In Vitro Aerodynamic Studies of Inhalation Powders Containing Ciprofloxacin…
In the case of capsule-based dry powder inhalation systems (DPIs), the selection of the appropriate capsule is important. The use of gelatin, gelatin-PEG, and HPMC capsules has become widespread in marketed capsule-based DPIs. We aimed to…
Developing and evaluation of orodispersible tablets containing caffeine
Starting from the premise that a reduced number of active pharmaceutical ingredients (APIs) are used to treat hypotension, the aim of this study consisted of developing new formulations of caffeine-orodispersible tablets (CAF-…
Pharmatrans introduces DICOM SANAQ SP204 proprietary excipient with alkaline agent
Pharmatrans Sanaq has now added DICOM SP 204 tailored to help formulation development of moisture sensitive APIs and to stabilize formulations where alkaline conditions need to be controlled to its DICOM SANAQ® range of high functionality…
Poster: Granfiller-D® & Hisorad® As New Co-processed Excipients For Orally Disintegrating…
Introduction: Tablets are still the most widely used dosage form for oral application due to their simple administration and relatively low manufacturing costs. One main disadvantage of tablets is the difficulty in swallowing or chewing.…
Podcast: Hot Melt Extrusion – Formulation Approaches and Technologies
While hot melt extrusion was developed in the 1930s and initially used in the plastics and food sector, the pharmaceutical industry has now firmly embraced this technology platform in its manufacturing as a way of solving formulation…
Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability…
Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing. The latest advancements include increased use of…
The Effect of Process Variables and Binder Concentration on Tabletability of Metformin Hydrochloride…
In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw extruder such that temperatures are maintained below melting point of drugs but above glass transition of…
Excipients and Their Attributes in Granulation
This chapter discusses different excipients traditionally used in granulation applications and the emerging high-functionality co-processed excipients that can improve granulation processing. Successful manufacturing of tablets or capsules…
Formulation and Evaluation of Thermosensitive Flurbiprofen In Situ Nano Gel for the Ocular Delivery
The contemporary research implicates the formulation and evaluation of a thermosensitive in situ nano gelling method to improve solubility and ocular residence time of flurbiprofen. This study was carried out in two phases. In the first…
Have a look at the next interesting webinars!
In the next weeks, several very interesting webinars for the excipient community are scheduled. Here, we made a short overview and explanation for some of them:
Our webinars:
ZoomLab™: Digitally guiding dosage form and formulation for…
Nanomaterials for Protein Delivery in Anticancer Applications
Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery…
Advantages and challenges of pharmaceutical 3D printing
The utilization of 3DP as manufacturing process might provide some potential benefits for the pharmaceutical industry as well as for patients. In regard to customization and tailoring of pharmaceutical dosage forms, 3DP appears to have a…
Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed…
Purpose
Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve…
An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across…
Oral administration is the most commonly used route for drug delivery owing to its cost-effectiveness, ease of administration, and high patient compliance. However, the absorption of orally delivered compounds is a complex process that…
A modular device for vaginal administration of multiple therapeutic agents
In this project, the aim is to develop a new multipurpose prevention technology (MPT) platform to help address the global health burdens associated with sexually transmitted infections (e.g. HIV-1, HSV-2, HPV) and unmet need for…
Controlled release of pharmaceutical agents using eutectic modified gelatin
Deep eutectic solvent (DES) is a class of ionic liquids, consisting of a mixture generally formed by combining hydrogen bond donors (HBDs) such as alcohols, amides and carboxylic acids with various quaternary ammonium salts. The decrease in…
Critical Tools in Tableting Research: Using Compaction Simulator and Quality by Design (QbD) to…
As commonly known, the product development stage is quite complex, requires intensive knowledge, and is time-consuming. The selection of the excipients with the proper functionality and their corresponding levels is critical to drug product…
Formulation and Evaluation of Naproxen Emulgel for Topical Delivery
Topical conveyance of medications can be accomplished by fusing drug into the gel network for viable conveyance of medications. NSAIDs are non-steroidal medications having superb mitigating and pain-relieving action however NSAIDs produces…
Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral…
Measles (Me) and rubella (Ru) viral diseases are targeted for elimination by ensuring a high level of vaccination coverage worldwide. Less costly, more convenient MeRu vaccine delivery systems should improve global vaccine coverage,…
Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and…
Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years. Given its considerable…
Phospholipids for mRNA vaccines from Lipoid
Synthetic phospholipids, which are used in the manufacture of mRNA vaccines and currently are the subject of particular public interest, are part of Lipoid's extensive product range.
As a growing, internationally active company and…
Technologies in 3D-printing
Dissertation by Ilias El Aita: Part 2
The term 3DP is an umbrella term encompassing several technologies, which differ in the printing style and/or used material. Nevertheless, these technologies have the same starting point in common as…
Analytical approach for lubricant characterization of excipients using the surface replication…
Lubricants are indispensable pharmaceutical ingredients for preventing tableting failure due to powder adhesion to the die wall. The impact of lubricants was evaluated with use of the Binding Identification for Net Detriment (BIND) surface…
Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend…
In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added…