Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using…
This study aimed to investigate the role of micellization of sodium lauryl sulfate (SLS) in poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using the anti-solvent method in enhancing the dissolution rate of practically…
Introduction to 3D-printing
Dissertation by Ilias El Aita: Part 1
For years, patients were viewed as a homogeneous group and selected drug treatment was based on experience from clinical studies. Consequently, individual factors such as age, physiological condition…
Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for…
To develop stable and inhalable dry powder formulations with long shelf life, polyplexes consisting of siRNA and a polyethylenimine (PEI)‐based block copolymer in presence of mannitol or trehalose are spray dried. The effect of inlet (T‐In)…
Lipids for pharmaceutical applications from Merck – Millipore Sigma
Lipids are the most widely used delivery system for mRNA therapeutics. Lipid nanoparticles (LNPs) provide a safe and effective drug delivery system to target COVID-19 and other diseases. Watch Merck's animated video about lipid…
The Effect of Drug Loading on the Properties of Abiraterone–Hydroxypropyl Beta Cyclodextrin Solid…
Abiraterone is a poorly water-soluble drug used in the treatment of prostate cancer. In our previous study, we reported that KinetiSol® processed solid dispersions (KSDs) based on hydroxypropyl β-cyclodextrin (HPBCD) showed improved…
Delivering therapeutic cannabinoids via skin: Current state and future perspectives
Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries. Concomitantly, scientists are showing…
Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug…
Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a…
New Kolliphor® P188 Bio from BASF
Parenteral grade surfactant designed for stabilizing biologic formulations
Biologic formulations require the most stringent requirements to be met in order to ensure patient safety and the optimal performance of the drug. Poloxamer 188 has…
Are you facing the challenge of replacing TiO₂ in your coating formulations? Get one of the limited…
For decades, titanium dioxide (TiO2) has been used as a white pigment due to its very high opacity and brightness. Therefore, it has a wide range of applications, from being a coloring ingredient of pharmaceutical film coating, to food…
Excipient companies at PBP World Meeting 2021
11 - 14 May 2021 | Online Conference
Due to the COVID crisis, the 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology and its accompanying exhibition ResearchPharm® will be held online.
A lot of our…
Melt extrusion deposition (MED™) 3D printing technology – A paradigm shift in design and development…
Three-dimensional printing (3DP) technology offers unique advantages for pharmaceutical applications. However, most of current 3D printing methods and instrumentations are not specifically designed and developed for pharmaceutical…
Integrated in silico formulation design of self-emulsifying drug delivery systems
The drug formulation design of self-emulsifying drug delivery systems (SEDDS) often requires numerous experiments, which are time- and money-consuming. This research aimed to rationally design the SEDDS formulation by the integrated…
Advances in powder bed fusion 3D printing in drug delivery and healthcare
Powder bed fusion (PBF) is a 3D printing method that selectively consolidates powders into 3D objects using a power source. PBF has various derivatives; selective laser sintering/melting, direct metal laser sintering, electron beam melting…
All excipient production sites with GMP certification
In the pharmaceutical world, the term GMP, or Good Manufacturing Practice, plays quite a big role. On this page, we explain what GMP stands for in general, and specifically for the pharmaceutical excipient industry.
Moreover, it is shown…
Binders in Pharmaceutical Granulation
Binders or “granulating agents” are a critical formulation component in tablets made by direct compression, as well as dry, wet, and melt granulation, ensuring appropriate plasticity, compactibility, and binding ability. In wet granulation,…
Novel Self-Nano-Emulsifying Drug Delivery Systems Containing Astaxanthin for Topical Skin Delivery
Astaxanthin (ASX) is a potent lipophilic antioxidant derived from the natural pigment that gives marine animals their distinctive red-orange colour and confers protection from ultraviolet radiation. Self nano-emulsifying drug delivery…
Exploring novel carrier for improving bioavailability of Itraconazole: Solid dispersion through…
Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion) which is used for taste masking and moisture protection, has shown the ability for forming solid dispersion. The present study aimed to check…
Drug Substance and Excipient Characterization
Characterization of drug substances and excipients is a very important step at the preformulation phase of product development. Although testing will involve additional time and cost, failure to carry out the appropriate characterization…
Development, optimization and in-vivo evaluation of cyanocobalamin loaded orodispersible films using…
Vitamin B12 deficiency is associated with high risks of cognitive decline, neuropathy, megaloblastic anaemia and depression. Therefore, there is a need to develop an innovative formulation of vitamin B12 to restore optimal serum vitamin B12…
Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica…
To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles…
Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
D-mannitol is a common polyol that is used as additive in pharmaceutical and personal care product formulations. We investigated its effect on the microstructure and rheology of novel non-aqueous Carbopol dispersions employing traditional…
Topical cellulose nanocrystals-stabilized nanoemulgel loaded with ciprofloxacin HCl with enhanced…
Spray-dried cellulose nanocrystals (CNC) were investigated as a potential stabilizer for the preparation of nanoemulsion gels (nanoemulgels) loaded with ciprofloxacin hydrochloride to act as dual-role gels capable of stimulating the tissue…
Development of Stable Amorphous Solid Dispersion and Quantification of Crystalline Fraction of…
This study aimed to improve the dissolution of the poorly soluble drug lopinavir (LPV) by preparing amorphous solid dispersions (ASDs) using solvent evaporation method. The ASD formulations were prepared with ternary mixtures of LPV,…
A Study to Enhance the Oral Bioavailability of S-Adenosyl-L-Methionine (SAME): SLN and SLN…
The endogenous molecule, S-adenosyl-L-methionine (SAMe) is a key factor due to its role in the methylation cycle and modulation of monoaminergic neurotransmission. Since many mental disorders have linked to the monoaminergic system, the…
GranuTools powder characterization study on the influence of the drug load on pharmaceutical blends…
It is well known that flow properties of powders are governed by the intrinsic grain properties and forces acting on and between the grains. It is no surprise that the amount of API present in a blend impacts powder processability.
To…
Manufacturability and Properties of Granules and Tablets Using the Eco-Friendly Granulation Method…
This study aimed to compare the manufacturability and granule and tablet properties of green fluidized bed granulation (GFBG) and of direct compression (DC). Acetaminophen was used as a low compactabil- ity model drug. The process time of…
World Asthma Day 2021
World Asthma Day (WAD) (May 5, 2021) is organized by the Global Initiative for Asthma, (GINA) (www.ginasthma.org), a World Health Organization collaborative organization founded in 1993. WAD is held each May to raise awareness of Asthma…
Human respiratory viral infections: Current status and future prospects of nanotechnology-based…
Respiratory viral infections are major cause of highly mortal pandemics. They are impacting socioeconomic development and healthcare system globally. These emerging deadly respiratory viruses develop newer survival strategies to live inside…
Advances in Twin-Screw Granulation Processing
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms. The technology has evolved rapidly due to the…
InhaLac® 300 – new from MEGGLE
InhaLac® 300 - portfolio extension with a fine milled lactose grade
InhaLac® 300 - a new inhalative lactose grade with specific particle size distribution is characterized by the typical flow- and surface-characteristic of fine milled…
Carbomer microgels as model yield-stress fluids
The review presents current research results for Carbopol-based microgels as yield-stress materials, covering three aspects: chemical, physical and rheological. Such a joint three-aspect study has no analog in the literature. The chemical…
Terahertz time-domain spectroscopy for powder compact porosity and pore shape measurements: An error…
Terahertz time-domain spectroscopy (THz-TDS) is a novel technique which has been applied for pore structure analysis and porosity measurements. For this mainly the anisotropic Bruggeman (AB-EMA) model is applied to correlate the effective…
Biotemplated Hollow Mesoporous Silica Particles as Efficient Carriers for Drug Delivery
We designed three types of hollow-shaped porous silica materials via a three-step biotemplate-directed method: porous hollow silica nanorods, hollow dendritic fibrous nanostructured silica (DFNS), and ultraporous sponge-like DFNS. The first…
Highly Branched Polymers Based on Poly(amino acid)s for Biomedical Application
Polymers consisting of amino acid building blocks continue to receive consideration for biomedical applications. Since poly(amino acid)s are built from natural amino acids, the same building blocks proteins are made of, they are…