Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Vibratory mixing of pharmaceutical powders on a single-tablet-scale
A single-tablet-scale mixing process, being part of a setup for the production of individualized tablets, is developed and studied. The process relies on the principle of vibratory mixing to achieve a homogeneous powder blend in the order…
Preparation and evaluation of vancomycin spray dried powders for pulmonary delivery
The aim of the current study was to achieve a dry powder formulation of vancomycin by spray drying whilst evaluating the effect of pH and excipient type and percentage used in formulation on particle characteristics and aerosolization…
Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line:…
Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw…
A promising dual-drug targeted delivery system in cancer therapy: nanocomplexes of…
Various nano-sized protein and lipid complexes are being investigated as drug delivery systems. The encapsulation of more than one drug in a single nanocomplex carrier could enhance the therapeutic potency and afford synergistic therapeutic…
Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical…
The present study is concerned with the QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced skin retention and permeation. The NLCs formulation was optimized employing a…
Optimal ultrasonication process time remains constant for a specific nanoemulsion size reduction…
This paper theorizes the existence of a constant optimum ultrasound process time for any size-reduction operation, independent of process parameters, and dependent on product parameters. We test the concept using the case of ‘ultrasonic…
Supersaturating drug delivery systems containing fixed-dose combination of two antihypertensive…
The purpose of this study was to associate the poorly water-soluble antihypertensive drugs candesartan cilexetil (CC) and hydrochlorothiazide (HCTZ) as fixed-dose combination, in the form of ternary Amorphous Solid Dispersions (ASD), using…
Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and…
Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of adult patients with active psoriatic arthritis. However, Apremilast’s low solubility restricts its dissolution and…
Application of mini ODTs and coin-shaped ODTs with high performance excipients for pediatric…
There is strong clinical need for pediatric formulations from healthcare professionals and caregivers since the number of available pediatric formulation is limited. Currently oral administration is the main route of administration for…
Tablet disintegration performance: Effect of compression pressure and storage conditions on surface…
The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does not only refer to the break up of the interparticle bonds, but also relates to the liquid absorption and…
Enhance API solubility. Achieve stable, high drug loads – with Parteck® MXP
Poor solubility of APIs is a critical challenge in drug development. One formulation technique to increase solubility and, consequently, improve bioavailability of drugs is hot melt extrusion (HME). With this technology, the API is…
Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction…
Orodispersible mini-tablets (ODMTs) are a promising dosage form for the pediatric use showing increasing interest from pharmaceutical industry. However, a scale-up process for ODMTs from a compaction simulator to a rotary tablet press…
Applications of Nanostructured Lipid Carriers: Recent Advancements and Patent Review
Nanostructured lipid carriers (NLCs) are a nano-particulate carrier system consisting of solid lipids, liquid lipids, emulsifying agents, and water. NLCs have gained continuous significance in recent times and have displayed tremendous drug…
Controlling drug release with additive manufacturing-based solutions
3D printing is an innovative manufacturing technology with great potential to revolutionise solid dosage forms. Novel features of 3D printing technology confer advantage over conventional solid dosage form manufacturing technologies,…
Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness
The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely…
The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid…
The aim of this work was to identify from a review of current literature the effects of lipids used in the development of Nanostructured Lipid Carriers (NLCs) on the physicochemical properties of the resulting formulation.
The size of…
New In Vitro Coculture Model for Evaluating Intestinal Absorption of Different Lipid Nanocapsules
Standard models used for evaluating the absorption of nanoparticles like Caco-2 ignore the presence of vascular endothelium, which is a part of the intestinal multi-layered barrier structure. Therefore, a coculture between the Caco-2…
Comparative taste-masking evaluation of microencapsulated bitter drugs using Smartseal 30D and…
The taste of drug substances plays a key role in the development of paediatric formulations with suitable organoleptic properties. The aim of the study was to evaluate the taste masking effectiveness of Smartseal 30D and ReadyMix on a range…
Exploring novel carrier for improving bioavailability of Itraconazole; Solid dispersion through Hot…
Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion) which is used for taste masking and moisture protection, has shown the ability for forming solid dispersion. The present study aimed to check…
Development and validation of a selective marker-based quantification of polysorbate 20 in…
Polysorbates are widely used as non-ionic surfactant in biopharmaceutical formulations. Recently, the degradation of polysorbate moved into the focus of attention, because in several published studies it was described, that stability issues…
Exploring the performance-controlling tablet disintegration mechanisms for direct compression…
The design and manufacture of tablets is a challenging process due to the complex interrelationships between raw material properties, the manufacturing settings and the tablet properties. An important factor in formulation and process…
Tefose® 63 – A nonionic oil-in-water emulsifier for topical formulations
Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate. The exact quantity of each component has been carefully selected to obtain a self-emulsifying base.…
Polymeric nanocapsules as a binder system for fluidized bed granules: Influence on particle growth…
The use of polymeric nanocapsules as a binder system to produce fluidized bed granules with improved in vivo bioavailability has recently been reported. This study evaluated how the nanocapsules influence the growth behavior of the…
How MEGGLE Excipients could make a valuable contribution in the fight against the pandemic
SARS-CoV-2, a RNA-virus within the Corona family, has affected mankind all over the world and was therefore declared as pandemic (COVID 19). Since first appearance of this infection, global science and technology has reacted incredibly…
Achieving gastroresistance without coating: Formulation of capsule shells from enteric polymers
Capsules are a widely used oral dosage form due to their simplicity and ease of manufacture. They are equally popular for both pharmaceutical and nutraceutical products and since they do not need extensive formulation development, it is a…
Chatbots – A blind spot of the pharma industry?
As you know, we are always looking for the latest solutions with added value for our partners and for the excipient industry in general. For quite some time now, more and more companies in other industries have been using a chatbot very…
Recent updates in COVID-19 with emphasis on inhalation therapeutics: Nanostructured and targeting…
The current world health threat posed by the novel coronavirus disease of 2019 (COVID-19) calls for the urgent development of effective therapeutic options. COVID-19 needs daunting routes such as nano-antivirals. Hence, the role of…
An overview on natural product drug formulations from conventional medicines to nanomedicines: Past,…
For decades, naturally produced plants have been studied and used in herbalism (herbal medicines). Despite being natural, these products were not of any interest of any of the major pharmaceutical companies. There are various reasons behind…
Formulation and Characterization of gallic acid and quercetin chitosan nanoparticles for sustained…
Cancer was ranked as the second leading cause of death, and colon cancer is recognized as third most common cancer worldwide with high morbidity and mortality. Chemotherapeutic drugs act on normal and cancerous cells similarly; therefore,…
Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel…
18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment. Due to its poor solubility, Gly is not suitable for…
A Semi-Mechanistic Prediction of Residence Time Metrics in Twin Screw Granulation
This work is concerned with the semi-mechanistic prediction of residence time metrics using historical data from mono-component twin screw wet granulation processes. From the data, several key parameters such as powder throughput rate,…
The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous…
The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical…
Folic Acid Decoration of Mesoporous Silica Nanoparticles to Increase Cellular Uptake and Cytotoxic…
Breast cancer is the most frequent cancer among women and impacts over two million women each year. Although many different types of anticancer agents are available for breast cancer treatment, doxorubicin is one of the most widely used…
A Guide to Drug Development for Biologics: Overcoming Formulation and Manufacturing Challenges
What are Biologics?
A biopharmaceutical product (commonly referred to as a “biologic”) is defined as a pharmaceutical drug product manufactured in, extracted from, or semi-synthesized from biological sources. Biologics include vaccines,…