Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis
The increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics constitute a public health issue, since tuberculosis still constitutes the primary cause of death in the world due to bacterial…
Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals
During the past two decades, the clinical use of biopharmaceutical products has markedly increased because of their obvious advantages over conventional small-molecule drug products. These advantages include better specificity, potency,…
Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel…
The objective of this study was to fabricate a novel drug delivery system using Soluplus® (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer) and glycyrrhizic acid to improve solubility, bioavailability, and…
The Development of Minitablets for a Pediatric Dosage Form for a Combination Therapy
Minitablets are an appealing option for an age-appropriate pediatric dosage form. In particular, for combination therapies where multiple active ingredients are dosed simultaneously, the use of minitablets will enable independent…
Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations…
This study aimed to develop and characterize a spray-dried powder aerosol formulation of a commercially available surfactant formulation, Survanta® intratracheal suspension, using the excipient enhanced growth (EEG) approach. Survanta EEG…
What is the smallest starter pellet for drug layering and coating?
Two weeks ago we created a poll with a high interaction rate in LinkedIn. The question was: "Pellets - How low can you go? What is the smallest size of starter pellets you can start drug loading and coating?". The answer options were "500…
Effects of Solvents, Emulsions, Cosolvents, and Complexions on Ex Vivo Mouse Myometrial…
A great need exists to develop tocolytic and uterotonic drugs that combat poor, labor-related maternal and fetal outcomes. A widely utilized method to assess novel compounds for their tocolytic and uterotonic efficacy is the isometric organ…
Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation…
Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both an economic and health benefit. In this review, we cover…
Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation and In…
Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated the prospects of drug-loaded SLNs to increase the ocular permeation and…
Combinatorial lipid-nanosystem for dermal delivery of 5-fluorouracil and resveratrol against skin…
In the present study, combinatorial nanostructured lipid carrier gel of 5-fluorouracil and resveratrol was formulated, optimized and characterized to enhance permeation in between epidermis and dermis layers of the skin to obtain a…
mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP…
Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of…
Alginates are biopolymers that have been investigated for their use in food and medical fields. Minimal information is available regarding their potential application as tablet superdisintegrants. Here we studied the disintegration action…
The effect of relative humidity and formulation variables on chewable xylitol-sorbitol tablets
Changing relative humidity levels challenge the manufacturing of chewable xylitol-sorbitol based tablets. The aim of the study is to investigate how the formulation of chewable xylitol-sorbitol tablets affects the properties of the powder…
Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs
Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of the weakly basic drug at…
Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and…
Veklury™ by Gilead Sciences, Inc., containing antiviral drug, remdesivir (REM) has received emergency authorization in the USA and in Europe for COVID-19 therapy. Here, for the first time, we describe details of the non-covalent, host-guest…
Characterization of Biological Material Adsorption to the Surface of Nanoparticles without a Prior…
Purpose
Current preclinical therapeutic strategies involving nanomedicine require increasingly sophisticated nanosystems and the characterization of the complexity of such nanoassemblies is becoming a major issue. Accurate characterization…
Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and…
Colloidal liquid-in-liquid nanodispersions such as micro- and nanoemulsions were developed, characterized and compared as potential carriers for the topical administration of ibuprofen. Both colloidal systems were based on water as the…
Biodegradable polymeric nanocarriers for oral delivery of antiretroviral drug: Pharmacokinetic and…
The current work aimed to formulate Darunavir (DRV) loaded poly (ɛ-caprolactone) nanoparticles (NPs) to address the issue of low bioavailability. NPs were formulated by employing D-α Tocopherol Polyethylene Glycol Succinate 1,000 (TPGS) as…
Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?
In this study, powder flowability is assessed during granular compaction under free surface conditions by using Hausner ratio (HR) as flowability index. Different kinds of pharmaceutical and food powders were examined. The assessment of the…
Designing cellulose hydrogels from non-woody biomass
Hydrogels are an attractive system for a myriad of applications. While most hydrogels are usually formed from synthetic materials, lignocellulosic biomass appears as a sustainable alternative for hydrogel development. The valorization of…
Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for…
The present work aimed to formulate intranasal insulin fast-dissolving films for treatment of anosmia in patients post COVID-19 infection. Variant films were prepared employing the casting method and using hydroxypropyl methyl cellulose and…
Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs
Parkinson’s disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer’s disease. In addition, there is a higher risk incidence in the elderly population.…
Nanocomposite sponges for enhancing intestinal residence time following oral administration
In this work, nanocomposites that combine mucopenetrating and mucoadhesive properties in a single system are proposed as innovative strategy to increase drug residence time in the intestine following oral administration. To this aim, novel…
World Malaria Day 2024
World Malaria Day, marked each year on 25 April, is an occasion to highlight the global efforts to end malaria and the need for sustained political commitment and continued investment for malaria control and elimination.
Through its 2024…
Nanostructured lipid carriers for enhanced in vitro and in vivo schistosomicidal activity of…
WHO considers praziquantel (PZQ) as the drug of choice for treatment of Schistosoma mansoni infection but this requires high dose due to poor solubility and first pass metabolism. The aim of this work was to optimize nanostructured lipid…
Evaluation of dissolution techniques for orally disintegrating mini-tablets
Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and…
Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic…
Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great…
Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation
The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting considerable advantages, has created challenges for researchers. Among the applications of nanocarriers, drug delivery to the skin has attracted…
Formulation and process strategies to minimize coat damage for compaction of coated pellets in a…
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage…
Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic…
Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of…
Polymeric Drug Delivery Systems by Additive Manufacturing
Additive manufacturing (AM) is gaining interests in drug delivery applications, offering innovative opportunities for the design and development of systems with complex geometry and programmed controlled release profile. In addition,…
The evolution of commercial drug delivery technologies
Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient…
Smart excipient improves powder flow for sachet-based products
BENEO presents galenIQ™ 721 for highly flowable and stable sachet powders
Mannheim (Germany), April 2021 – Sachets are a popular pharmaceutical and nutraceutical packaging format for consumers and manufacturers alike. To ensure accurate…
How Cellets’ particle size influences the flow behavior in a Wurster fluid-bed coater
Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial…