Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Synergistic application of twin-screw granulation and selective laser sintering 3D printing for the…
This study demonstrated the first case of combining a novel continuous granulation technique with powder-bed fusion-based selective laser sintering (SLS) process to enhance the dissolution rate and physical properties of a poorly…
Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID‐19 vaccine
On the first day of the UK vaccination campaign with the coronavirus disease 2019 (COVID‐19) vaccine, there were reports of 2 cases of anaphylaxis within minutes of administration of the Pfizer/BioNTech messenger RNA (mRNA) vaccine and a…
Effects of Concentrating Cannabinoid Loaded Liposome Formulations
Introduction
Phytocannabinoids are chemical compounds found in the cannabis plant which have been increasingly used as therapeutics in recent years . They have shown to aid in chronic pain management for several diseases such as…
Drug solubilization during simulated pediatric gastro-intestinal digestion
To increase the understanding of how drugs behave following oral administration to the pediatric population, the aim of the present study was to investigate the solubilization of fluconazole and ibuprofen during simulated gastro-intestinal…
Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful…
Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively…
Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid…
The purpose of the study was to develop a novel, directly compressible, co-processed excipient capable of providing a controlled-release drug system for the pharmaceutical industry. A co-processed powder was formed by adsorption of solid…
World Immunization Week 2021
World Immunization Week – celebrated every year in the last week of April – aims to promote the use of vaccines to protect people of all ages against disease. Immunization saves millions of lives every year and is widely recognized as one…
Coating characterization by hyperspectroscopy and predictive dissolution models of tablets coated…
The objective of current research was to develop the models of dissolution prediction of tablets coated with cellulose acetate (CA 320S or CA 398-10) and cellulose acetate phthalate (C-A-P) blends. Independent variables selected were…
Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions
The current study deals with formulation and evaluation of nateglinide solid dispersion (SD) incorporate into tablet formulation for controlled release of the drug.
Methods: The nateglinide SD prepared using crospovidone and…
Removal of azithromycin from aqueous bulk solution using water/ethanol/transcutol/capryol-90 green…
The present work aimed to remove azithromycin (AZM) from contaminated aqueous system using a water/ethanol/transcutol/capryol-90 green nanoemulsion. The drug is identified as potential pharmaceutical drug for detrimental effect on flora and…
Formulate and Evaluate Famciclovir Floating Tablets
Floating drug delivery system of famciclovir was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability by using different polymers like HPMC E15, Xanthan gum, methyl cellulose and compritol 888…
Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different…
Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia…
Effects of monoclonal antibody concentration and type of bulking agent on critical quality…
Biopharmaceuticals represent one of the fastest growing areas in the pharmaceutical industry. Previously, protein formulations for intravenous applications were most widespread, while now the subcutaneous route of administration is gaining…
Polymeric Nanoreactors as Emerging Nanoplatforms for Cancer Precise Nanomedicine
How to precisely detect and effectively cure cancer which is defined as precise nanomedicine has drawn great attention worldwide. Polymeric nanoreactors which can in situ catalyze inert species into activated ones, can greatly increase…
Application of Modified SeDeM Expert Diagram System for Selection of Direct Compression Excipient…
In the present investigations, the SeDeM expert diagram system, modified to include two important compression properties, i.e. mean yield pressure, Py, and compactibility parameter, σtmax, was used to identify a diluent most suitable for…
Design and characterisation of an amorphous formulation of nifedipine for the treatment of autonomic…
Current treatment for autonomic dysreflexia (AD) involves rupturing a liquid-filled soft capsule of nifedipine to aid rapid drug release and absorption, however, this application is not covered under the manufacturer's license. The…
Ocular Implants for Drug Delivery: Improving Patient Outcomes
Did you know that there are already 11 ocular implants on the market and over 30 in development? (See Table 1 and Figure 2). Every year, more and more people live with eye disease or vision impairment of some kind, requiring treatment to…
Mathematical Modeling of Release Kinetics from Supramolecular Drug Delivery Systems
Winner of the Pharmaceutics 2021 Best Paper Awards
Embedding of active substances in supramolecular systems has as the main goal to ensure the controlled release of the active ingredients. Whatever the final architecture or entrapment…
3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology
Winner of the Pharmaceutics 2021 Best Paper Awards
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was…
Sustained release of peptides and proteins from polymeric nanocarriers produced by inverse Flash…
Peptide and protein therapeutics generally exhibit high potency and specificity and are increasingly important segments of the pharmaceutical market. However, their clinical applications are limited by rapid clearance and poor membrane…
Draft landscape and tracker of COVID-19 candidate vaccines
The COVID-19 candidate vaccine landscape and tracker database compiles detailed information on COVID-19 vaccine candidates in development.
The landscape is updated regularly - twice a week (Tuesday and Friday, 17:00 CET).
The…
Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation
Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles. Polymers of N-(3-aminopropyl) methacrylamide hydrochloride (APMA) are cationic with primary amine…
The method of random balance for studying the influence of excipients quantities on technological…
The aim of the research was to study the influence of excipients amount on the technological parameters of the compression mixture and tablets based on dry extract of Origanum vulgare L. herb using the method of random balance.
Materials…
Optimization of Wurster fluid bed coating: Mathematical model validated against pharmaceutical…
Wurster fluid bed coating is an effective way of manufacturing pharmaceutical pellets requiring specific characteristics such as high drug loading or enteric protection. The optimization of the coating process can be demanding because it…
Impact of co-processed excipient particles solidity and circularity on critical quality attributes…
The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed to identify the most important morphological attributes influencing the flowability…
Innovation in Tablet Disintegration Testing
Innovative bathless disintegration tester with automatic end-point detection. The bathless DT50 sets new standards in fast and user-friendly operation.
Induction heating technology reduces heating times to only 3 - 5 minutes and…
galenIQ™ – Ask the expert! – Webinar recording
We had a webinar with the experts from BENEO to find out more on galenIQ™. See here some answers to the questions asked from participants of the webinar and have a look at the full webinar recording.
galenIQ™ is a soluble filler and…
Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen…
In the last few decades, nanotechnology has emerged as an important tool aimed at enhancing the immune response against modern antigens. Nanocarriers designed specifically for this purpose have been shown to provide protection, stability,…
Preparation of Silymarin–quercetin Loaded Nanoparticles by Spontaneous Emulsification Solvent…
Silymarin, a flavonolignan, derived from Silybum marianum, family Asteraceae has long been used as a hepatoprotective remedy. Silymarin has cytoprotective activities due to its antioxidant property and free radical scavenging activity. The…
Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile…
Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical…
Development of FDM 3D-printed tablets with rapid drug release, high drug-polymer miscibility and…
Some of the major issues with the development of FDM 3D printed tablets are slow drug release, lack of drug-polymer miscibility, high processing temperature, and poor printability. In this investigation, these issues were addressed by using…
The effect of trehalose, antioxidants, and acetate buffer concentration on oxytocin stability
Oxytocin is a cyclic nonapeptide used to induce labor and prevent bleeding after childbirth. Due to its instability, storage and transport of oxytocin formulations can be problematic in hot/tropical climates. The aim of this study was to…
Influence of drug-carrier compatibility and preparation method on the properties of…
The main objective of this paper is to elucidate the influence of drug-carrier compatibility and preparation method on the properties of Paclitaxel (PTX)-loaded lipid liquid crystalline nanoparticles (LLCNs). Here, glyceryl monooleate…
Oral delivery of peptide therapeutics in infants: Challenges and opportunities
Abstract: The vast majority of drugs are not designed or developed for pediatric and infant populations. Peptide drugs, which have become increasingly relevant in the past several decades, are no exception. Unfortunately, nearly…