Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Rapid prototyping of miniaturized powder mixing geometries
Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel…
Bioadhesive Films as Drug Delivery Systems
Bioadhesive films are considered a novel drug delivery system that provides improved therapy and better patient compliance than conventional dosage forms. The type and concentration of polymer or the blend of polymers used are important…
Programmable immune activating electrospun fibers for skin regeneration
Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing. How to programmatically activate sequential immune responses is the key for scarless skin regeneration. In this study, an…
ZoomLab™ features now the new Dissolution Profile Comparison module
Have you tried the new Dissolution Profile Comparison module in ZoomLab™?
The new module calculates the similarity factor (f2 value) and other parameters to help formulators evaluate if the dissolution profile of two formulations are…
Development, Pre-clinical Investigation and Histopathological Evaluation of Metronidazole Loaded…
Background: Metronidazole (MTZ) is an anti-oxidant and anti-inflammatory agent with beneficial therapeutic properties. The hydrophilic nature of the molecule limits its penetration across the skin. Existing commercial formulations have…
Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability…
Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of raw material properties, especially considering batch-to-batch variability. The importance…
Hydrogels in Hand Sanitizers
Hand hygiene can be considered a strategic key useful in the containment of infections such as COVID-19 both at home and in communities because it can dramatically reduce the widespread outbreak of infections. In case of the unavailability…
Garcinol Encapsulated Ph-Sensitive Biodegradable Nanoparticles: A Novel Therapeutic Strategy for the…
The emergence of pH-sensitive nanoscale particles is beneficial due to their ability to only release cargo in a colonic pH environment, which helps to directly target inflamed tissues in inflammatory bowel disease (IBD). Hence, we have…
Development of poly-L-lysine multi-functionalized muco-penetrating self- emulsifying drug delivery…
Salmonella typhi infections are difficult to treat due to poor penetration of current antibiotic ciprofloxacin (CIP)modalities into the intracellular compartments of macrophages owing to poor solubilization and oral bioavailability. Poor…
Study on Applicability of ODTs with Co-processed Excipient to Continuous Manufacturing Process
“Continuous Manufacturing (CM)” is a manufacturing method in which raw or blended materials are continuously charged to the processing line, and products are continuously discharged throughout the duration of the process. CM method is of…
Size Shifting of Solid Lipid Nanoparticle System Triggered by Alkaline Phosphatase for Site Specific…
We aim to prepare a size-shifting nanocarrier for site-targeting mucosal drug delivery that can penetrate through mucus gel layer and remain close to the absorption membrane. As nanocarriers can be engineered to penetrate mucus but they can…
Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with…
Salidroside (SAL) is a phenolic substance with high solubility and low permeability, which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora, resulting in lower bioavailability. The aim of this…
Evaluation and Comparison of Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers…
The aim of this study was the optimization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in terms of physicochemical and biopharmaceutical properties, to develop effective and stable aqueous liquid formulations…
Roquette’s Video Blog: Ask the Experts
See the newest publication from Roquette's video blog here
Ask the experts: "One way that biopharmaceutical manufacturers can keep up with demands in the industry, is by streamlining complex workflows. But to do this, they need innovative…
Product and process development applying Quality by Design and Design of Experiment concepts to…
The QbD (quality by design) approach is a modern concept for the development of pharmaceutical products and manufacturing processes aiming for a consistent reproducible quality. Risk assessment is performed at defined milestones in order to…
Studies on Formulation and Evaluation of Eudragit RS PO Based Nanoparticulate System of Aceclofenac…
Aim: Ocular drug delivery is the most challenging and interesting goal in front of the pharmaceutical scientist. Ocular inflammation is the most commonly affecting disease of the eye. The objectives of present investigation were to…
Understanding the Synergistic Correlation between the Spatial Distribution of Drug-Loaded Mixed…
To better promote the application of polymeric mixed micelles (PMMs), a coarse-grained molecular dynamics simulation (CGMD) has been employed to investigate the factors controlling the spatial distribution within the PMMs and predict their…
A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
Aim: The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell…
Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug…
This study exposes the potential usefulness of a new co-processed excipient, composed of alginic acid and microcrystalline cellulose (Cop AA-MCC), for the preparation of immediate drug release tablets by direct compression. Evaluation of…
In vitro and in vivo correlation for lipid-based formulations: Current status and future…
Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs. However, construction of in vitroand in vivo correlations (IVIVCs) for LBFs is quite challenging, owing to a…
Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles
The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is known to be increasing due to an aging population and is anticipated to further grow in the decades ahead. The treatment of brain diseases is…
Optimized semisolid self-nanoemulsifying system based on glyceryl behenate: A potential nanoplatform…
Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator used for treatment and protection against postmenopausal osteoporosis. The drug has been used for protection against breast cancer and more recently, for management…
Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment
Peptic ulcer disease (PUD) is a common condition that is induced by acid and pepsin causing lesions in the mucosa of the duodenum and stomach. The pathogenesis of PUD is a many-sided scenario, which involves an imbalance between protective…
Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution
Stability studies represent an essential component of pharmaceutical development, enabling critical evaluation of the therapeutic potential of an active pharmaceutical ingredient (API) or a final pharmaceutical product under the influence…
Buccal Resveratrol Delivery System as a Potential New Concept for the Periodontitis Treatment
The health benefits of resveratrol have been proven to inhibit the development of numerous diseases. A frequent limitation in its use is a low bioavailability stemming from a poor solubility and fast enterohepatic metabolism. Thus, the aim…
World Health Day
April 7 of each year marks the celebration of World Health Day. From its inception at the First Health Assembly in 1948 and since taking effect in 1950, the celebration has aimed to create awareness of a specific health theme to highlight a…
Development and Optimization of TPGS based Stealth Liposome of Doxorubicin Using Box-Behnken Design:…
The present work reports the development of doxorubicin (DOX) encapsulated α-Tocopherol polyethylene glycol 1000 succinate (TPGS) coated liposomal system (DOX-LIPO-TPGS) by quality by design (QbD) approach and evaluated for its anticancer…
Towards the Prevention of Coronavirus Infection: What Role Can Polymers Play?
Severe Acute Respiratory Syndrome associated coronavirus 2 (SARS-CoV-2) has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of…
Digestion of Lipid-Based Formulations Not Only Mediates Changes to Absorption of Poorly Soluble…
The aim of this study was to evaluate the effect of lipid digestion on the permeability and absorption of orally administered saquinavir (SQV), a biopharmaceutics classification system (BCS) class IV drug, in different lipid-based…
Supersaturable self-microemulsifying delivery systems: an approach to enhance oral bioavailability…
This study explored the design of supersaturable self-microemulsifying drug delivery systems (S-SMEDDS) to address poor solubility and oral bioavailability of a novel benzimidazole derivative anticancer drug (BI). Firstly,…
Formulation and Optimization of Atovaquone Micronized Suspension by Top-down Method
Aim: The present work aimed to tackle the solubility issue of a Biopharmaceutics Classification System (BCS) II drug, Atovaquone.
Methods: Formulation of micronized suspension of atovaquone was optimized by employing a 32 full factorial…
Formulation and evaluation of transdermal nanogel for delivery of artemether
Artemether (ART) is second to artesunate in being the most widely used derivatives of artemisinin in combination therapy of malaria. Nanostructured lipid carrier (NLC) formulations were prepared following our previous report using optimized…
Thermoplastic Cellulose-Based Compound for Additive Manufacturing
The increasing environmental awareness is driving towards novel sustainable high-performance materials applicable for future manufacturing technologies like additive manufacturing (AM). Cellulose is abundantly available renewable and…
Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary…
Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual…