Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Tablet disintegration performance: effect of compression pressure and storage conditions on surface…
The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does not only refer to the break up of the interparticle bonds, but also relates to the liquid absorption and…
Rettenmeier Iberica Site in Barcelona, Spain receives EXCiPACT GDP Certification as a Pharmaceutical…
Brussels, 23 March 2021
EXCiPACT asbl is pleased to announce that the Rettenmeier Iberica SL y Cia S.C site in Barcelona, Spain has recently been awarded an EXCiPACT GDP Certificate from Aenor, one of EXCIPACT’s internationally…
World Tuberculosis Day 2024
What is the World Tuberculosis Day?
Each year, WHO commemorates World Tuberculosis (TB) Day on March 24 to raise public awareness about the devastating health, social and economic consequences of TB, and to step up efforts to end the…
Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol…
Clozapine is widely used to treat schizophrenia as an atypical antipsychotic. Low solubility, poor dissolution rate, degradation in the gastrointestinal tract, high hepatic first-pass metabolism, and eventually less drug transfer in the…
Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid…
Solid lipid nanoparticles (SLNs) considered as an alternative vehicle for the enhanced oral absorption of drugs, and also to enhance therapeutic effectiveness after oral administration. Pharmacodynamic activity of drug is mainly describes…
Design of a Vertical Loss-in-Weight Feeder Prototype with Experimental Proof of Concept Validation
Loss-in-Weights (LiW) feeders are commonly oriented in a horizontal way. In this work, an experimental proof of concept, including mechanical and electrical design, construction, and operation, of a vertical LiW feeder prototype is…
Development and Evaluation of Cocoa Butter Taste Masked Ibuprofen Using Supercritical Carbon Dioxide
Masking the unpleasant taste of the pharmaceutically active ingredients plays a critical role in patient acceptance, particularly for children. This work’s primary objective was the preparation of taste-masked ibuprofen microparticles using…
Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with…
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two or more (initially crystalline) low molecular weight components that form a homogeneous single-phase amorphous system. Over the past decades, CAMS have…
A meticulous overview on drying-based (spray-, freeze-, and spray-freeze) particle engineering…
Drying is an indispensable operation in the preparation of pharmaceutical powders and always remained one of the energetic tasks in the pharmaceutical industry. Improving the stability, solubility, and dissolution of pharmaceutical products…
Quantitative Chemical Profiling of Commercial Glyceride Excipients via 1H NMR Spectroscopy
Glycerides are the main components of oils, and fats, used in formulated products in the food and cosmetic industry as well as in the pharmaceutical product industry. However, there is limited literature available on the analysis of the…
Novel formulations and drug delivery systems to administer biological solids
Recent advances in formulation sciences have expanded the previously limited design space for biological modalities, including peptide, protein, and vaccine products. At the same time, the discovery and application of new modalities, such…
Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro
Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of…
Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation…
The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers.…
Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP…
The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in…
Transferrin-functionalized lipid nanoparticles for curcumin brain delivery
Curcumin is an anti-inflammatory and antioxidant compound with potent neuroprotective activity. Due to its poor water solubility, low bioavailability, rapid elimination and the challenges for crossing and transposing the blood-brain barrier…
Fabrication of porous polyethyleneimine-functionalized chitosan/Span 80 microspheres for adsorption…
Porous surface-modified microspheres can have widespread applications in the removal of wastewater pollutants. In this study, using a nonionic surfactant (Span80) as the pore-forming agent and Zr4+ as the cross-linking agent,…
Comparative evaluation study of polycomplex carriers based on Eudragit® EPO/S100 copolymers prepared…
Interpolymer complexes (IPC) Eudragit® EPO/S100 were prepared in different media (water pH of 7.0 and ethanol). According to the elemental analysis, FTIR spectroscopy, and thermal analysis data, IPC prepared in aqueous media (denoted as…
Highway to Success – Developing Advanced Polymer Therapeutics
Polymer therapeutics are advancing as an important class of drugs. Polymers have already demonstrated their value in extending the half‐life of proteins. They show great potential as delivery systems for improving the therapeutic index of…
Tocotrienols-Rich Naringenin Nanoemulgel for the Management of Diabetic wound: Fabrication,…
The present research had been attempted to formulate and characterize tocotrienols-rich naringenin nanoemulgel for topical application in chronic wound conditions associated with diabetes. In due course, different phases of the nanoemulsion…
Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in…
Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug absorption mechanisms from ASDs in humans is incomplete. Aiming to gain insights…
Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug…
In vitro behavior of dronedarone hydrochloride loaded pellets using vacuum impregnation technique
Pharmaceutical pellets are a versatile and adaptable drug carrier system with pharmacological and technological advantages specific to multiparticulate delivery systems. Depending on their porosity and formulation procedure, a controlled…
Surfactants, Nanomedicines and Nanocarriers: A Critical Evaluation on Clinical Trials
Advances, perspectives and innovation in drug delivery have increased in recent years; however, there is limited information available regarding the actual presence of surfactants, nanomedicines and nanocarriers in investigational medicinal…
Excipients in the Paediatric Population: A Review
This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review…
Microfluidics for nanomedicines manufacturing: An affordable and low-cost 3D printing approach
During the last decade, an innovative lab on a chip technology known as microfluidics became popular in the pharmaceutical field to produce nanomedicines in a scalable way. Nevertheless, the predominant barriers for new microfluidics users…
Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route
Self-microemulsifying drug delivery systems (SMEDDSs) have recently returned to the limelight of academia and industry due to their enormous potential in oral delivery of biomacromolecules. However, information on gastrointestinal lipolysis…
Formulation of Medicated Chewing Gum Containing Sceletium tortuosum and Process Optimization…
Sceletium tortuosum is one of the most promising medicinal plant species for treating anxiety and depression. Traditionally, aerial parts are chewed (masticatory herbal medicine) providing fast relief and rendering the masticatory route for…
Impact of Critical Material Attributes (CMAs)-Particle Shape on Miniature Pharmaceutical Unit…
The U.S. Food and Drug Administration (FDA) emphasizes drug product development by Quality by Design (QbD). Critical material attributes (CMAs) are a QbD element that has an impact on pharmaceutical operations and product quality.…
A Multi-variate Mathematical Model for Simulating the Granule Size Distribution in Roller…
Granule size distribution (GSD) is one of the critical quality attributes in the roller compaction (RC) process. Determination of GSD for newly developed pharmaceutical compounds with unknown ribbon breakage behaviors at the RC milling step…
Repurposing Melt Degradation for the Evaluation of Mixed Amorphous-Crystalline Blends
Medicine regulators require the melting points for crystalline drugs, as they are a test for chemical and physical quality. Many drugs, especially salt-forms, suffer concomitant degradation during melting; thus, it would be useful to know…
Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation…
Three-dimensional printing (3D-printing) is a technology that prints the products layer-by-layer, in which materials are deposited according to the digital model designed by computer aided design (CAD) software. This technology has…
Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate…
Despite its proven efficacy in diverse metabolic disorders, quercetin (QU) for clinical use is still limited because of its low bioavailability. D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) is approved as a safe pharmaceutical…
The most compactible Microcrystalline Cellulose: Ceolus™ KG-1000
On behalf of Asahi, Seppic is happy to present you the most highly compactible microcrystalline cellulose Ceolus™ KG 1000.
You look for a solution to poorly compactible API by direct compression:
Preventing the tableting issues and…
Characterization of a Novel Drying Technology for Continuous Processing of Cohesive Materials: An…
This work addresses the influence of several process parameters on the performance of a novel drying device (patent NL2020740B1). In the new dryer, the processed substance is conveyed through the grooves of a large rotor via an interlocking…