Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Evaluating mechanical properties and tabletability of pharmaceutical powders with a novel…
Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing in the early phases of development can save a significant amount of resources in the long…
The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing…
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion…
Evaluation of polymer choice on immunogenicity of chitosan coated PLGA NPs with surface-adsorbed…
Polymeric nanoparticles (NPs) are recognized as potential delivery vehicles for vaccines. PLGA is a biocompatible polymer synonymous with polymeric NPs, which can be coated with other polymers such as chitosan that has intrinsic adjuvant…
3DP Printing of Oral Solid Formulations: A Systematic Review
Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and…
Formulation of Cannabidiol in Colloidal Lipid Carriers
In this study, the general processability of cannabidiol (CBD) in colloidal lipid carriers was investigated. Due to its many pharmacological effects, the pharmaceutical use of this poorly water-soluble drug is currently under intensive…
Versatility on demand – The case for semi-solid micro-extrusion in pharmaceutics
After additive manufacturing of pharmaceuticals has been introduced as viable method to produce individualized drug delivery systems with complex geometries and release profiles, semi-solid micro-extrusion has shown to be uniquely…
Programmable immune activating electrospun fibers for skin regeneration
Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing. How to programmatically activate sequential immune responses is the key for scarless skin regeneration. In this study, an…
Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of…
Innovative formulations, including solid lipid nanoparticles (SLNs), have been sought to improve skin permeation of non-steroidal anti-inflammatory drugs (NSAIDs). The present study explores the use of SLNs, prepared using a…
Survey on typical dosing vehicles used to simplify the administration of pediatric medicines
On behalf of Prof. Dr. Sandra Klein University of Greifswald we gladly invite you to participate in this survey on typical dosing devices to administer pediatric medicines and with this support the development of "better medicines for…
Drug Carriers: Classification, Administration, Release Profiles, and Industrial Approach
This work is aimed at providing a description of the complex world of drug carriers, starting from the description of this particular market in terms of revenue. Then, a brief overview of several types of conventional and innovative drug…
High Acceptability of an Orally Dispersible Tablet Formulation by Children
There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of a novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium…
Oral Insulin Delivery by Chitosan Coated Solid Lipid Nanoparticles: ex vivo and in vivo Studies
The objective of this investigation was to formulate chitosan coated, insulin-loaded solid lipid nanoparticles (SLN) for oral administration and investigate their potential as an effective alternative to the subcutaneous injection.…
Special Issue “A perspective of drug delivery and translational research in Europe”
The present Special Issue on Drug Delivery and Translational Research in Europe brings together representative examples of the work being carried out in pharmaceutical laboratories, both within universities or research institutions, and in…
Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer
Cancer is one of the biggest healthcare concerns in our century, a disease whose treatment has become even more difficult following reports of drug-resistant tumors. When this happens, chemotherapy treatments fail or decrease in efficiency,…
Resveratrol-loaded nanomedicines for cancer applications
Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant…
Microneedle for transdermal drug delivery: current trends and fabrication
Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal…
Computational avenues in oral protein and peptide therapeutics
Proteins and peptides are amongst the most sought-after biomolecules because of their exceptional potential to cater to a vast range of diseases. Although widely studied and researched, the oral delivery of these biomolecules remains a…
Liqui-Tablet: the Innovative Oral Dosage Form Using the Newly Developed Liqui-Mass Technology
In this study, an attempt was made to produce Liqui-Tablets for the first time. This was carried out through the compaction of naproxen Liqui-Pellets. The incentive to convert the novel Liqui-Pellet into Liqui-Tablet was due to the array of…
Functionality evaluation of co-processed excipients
Tablets constitute about 80–90% of dosage forms commonly prescribed by medical practitioners for therapeutic management of disease conditions. It is a solid dosage form that exercises advantages over other dosage forms because of its ease…
Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and…
Naloxone is an opioid receptor antagonist that can eradicate all pre-indications of the toxicity and inverse the opioid overdose. However, oral administration of naloxone offers limitations such as its extensive first-pass metabolism that…
Capturing the value in printed pharmaceuticals – A study of inkjet droplets released from a…
The future of personalised combination dosages will rely on the programming and delivery of multiple, separate APIs, their carrier fluids and excipients to a stable matrix, where each will remain separate until it is needed to be…
Layer by Layer: The Fundamentals of Multi-Layer Tableting
Multi-layer tableting offers a straightforward solution for a variety of challenging formulations. From multi-phasic release systems— to combinations of incompatibles (APIs)—to gastro-retentive tablets, this underutilized method…
Development of gastro-resistant coated probiotic granulates and evaluation of viability and release…
Probiotics have become one of the most consumed food supplements worldwide. Many probiotic strains are sensitive to low pH and bile concentrations encountered in the gastrointestinal tract upon oral ingestion. This study aimed at developing…
PMC Group International Announces Acquisition of Copperhead Chemical Company
MOUNT LAUREL, N.J.--(BUSINESS WIRE)--PMC Group International, Inc., which is an independent arm of PMC Group Companies, announced the acquisition of Cobra Investments Management Inc. and its two subsidiaries, Copperhead Chemical Company…
Predicting process design spaces for spray drying amorphous solid dispersions
Amorphous solid dispersions (ASDs) are commonly manufactured using spray-drying processes. The product quality can be decisively influenced by the choice of process parameters. Following the quality-by-design approach, the identification of…
Solvent-free temperature-facilitated direct extrusion 3D printing for pharmaceuticals
In an era moving towards digital health, 3D printing has successfully proven its applicability in providing personalised medicine through a technology-based approach. Among the different 3D printing techniques, direct extrusion 3D printing…
Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for…
Three-dimensional (3D) printing is an innovative additive manufacturing technology, capable of fabricating unique objects in a layer-by-layer manner. Semi-solid extrusion (SSE) is a subset of material extrusion 3D printing, based on the…
Tailoring immediate release FDM 3D printed tablets using a Quality by Design (QbD) approach
The aims of this work were to produce immediate release printed tablets using fused deposition modelling (FDM) technique and to systematically explore the effects of different compositions on drug release by Quality by Design approach.…
A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release…
This study is focused on the use of glyceryl behenate as a lipophilic excipient of matrix tablets providing controlled drug release. The aim of this study was to evaluate activation energy (EA) and changes of the thermodynamic parameters…
Polymers and Nanoparticles for Statin Delivery: Current Use and Future Perspectives in…
Atherosclerosis-related coronary artery disease (CAD) is one of the leading sources of mortality and morbidity in the world. Primary and secondary prevention appear crucial to reduce CAD-related complications. In this scenario, statin…
Effect of Carrier Type and Tween® 80 Concentration on the Release of Silymarin from Amorphous Solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug…
Recent update of toxicity aspects of nanoparticulate systems for drug delivery
Potential research outcomes on nanotechnology-based novel drug delivery systems since the past few decades attracted the attention of the researchers to overcome the limitations of conventional deliveries. Apart from possessing enhanced…
A Lipid-Based Depot Formulation with a Novel Non-lamellar Liquid Crystal Forming Lipid
Non-lamellar liquid crystal (NLLC)-forming lipids have gained attention as a novel component because of their ability to self-assemble upon contact with body fluids. In this study, a novel NLLC-forming lipid, mono-O-(5, 9,…
The Influence of Lipid Excipients on Platelet Function and the Pharmacodynamic Effects of Aspirin
The combination of pharmaceutical lipid excipients with aspirin in a novel liquid oral formulation (Vazalore) limits gastrointestinal toxicity of aspirin. This study was performed to determine whether the lipid excipients influence the…