Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical,…
This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on…
Analyzing Ophthalmic Suspension Particle Size Distributions Using Laser Diffraction: Placebo…
The current study demonstrated that the presence of excipients can interfere with the measurement of particle size distribution (PSD), a critical quality attribute of ophthalmic suspensions, by laser diffraction (LD) and that a placebo…
Versatile Use of Chitosan and Hyaluronan in Medicine
Chitosan is industrially acquired by the alkaline N-deacetylation of chitin. Chitin belongs to the β-N-acetyl-glucosamine polymers, providing structure, contrary to α-polymers, which provide food and energy. Another β-polymer providing…
Development of Immediate Release 3D-Printed Dosage Forms for Poorly Water-Soluble Drugs by Fused…
3D-printing technologies such as Fused Deposition Modeling (FDM) bring a unique opportunity for personalized and flexible near patient production of pharmaceuticals, potentially improving safety and efficacy for some medications. However,…
Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts
The biggest obstacle to the treatment of diseases that affect the central nervous system (CNS) is the passage of drugs across the blood-brain barrier (BBB), a physical barrier that regulates the entry of substances into the brain and…
The pulmonary route as a way to drug repositioning in COVID-19 therapy
The outbreak of the disease caused by the new coronavirus (COVID-19) has been affecting society’s routine and its patterns of interaction worldwide, in addition to the impact on the global economy. To date, there is still no clinically…
Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In Vitro–In Silico Approach
The use of physiologically based pharmacokinetic (PBPK) models to support drug product development has become increasingly popular. The in vitro characterization of the materials of the formulation provides valuable descriptors for the in…
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP…
Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic…
Cannabis-Based Oral Formulations for Medical Purposes: Preparation, Quality and Stability
Current legislation in Italy provides that medical Cannabis may be administered orally or by inhalation. One of the fundamental criteria for the administration of oral formulations is that they deliver a known consistent quantity of the…
Oral drug delivery: Conventional to Long Acting New-Age Designs
The Oral route of administration forms the heartwood of the ever-growing tree of drug delivery technology. It is one of the most preferred dosage forms among patients and controlled release community. Despite the high patient compliance,…
Lipid excipients to unlock oral bioavailability issues
Many active pharmaceutical ingredients have poor water-solubility and/or low permeability, leading to bioavailability issues. Lipid-based formulation (LBF) is a well-known strategy to overcome these hurdles and increase in vivo drug…
Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability…
Meclizine shows poor oral bioavailability and slow onset of action due to its low water solubility and poor permeability. In the present study, meclizine-loaded nanostructured lipid carriers (NLCs) were developed to improve oral…
Modeling the Coating Layer Thickness in a Pharmaceutical Coating Process
Although mechanistic numerical simulations can offer great insights into a process, they are limited with respect to resolved process time. While statistical models provide long-term predictability, determining the underlying probability…
Patent landscape of paediatric-friendly oral dosage forms and administration devices
The current availability in dosage forms designed specifically for children is limited, constituting common practice the use of unlicensed or off-labeled medicines and extemporaneous preparations. Swallowing difficulties and taste aversion…
Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and…
Spray drying is a constructive single-step manufacturing technique used to produce dry powder. Spray drying plays a remarkable role in producing inhalable powder formulations due to its ability to engineer particles with optimized…
Optimization of semisolid extrusion (pressure-assisted microsyringe)-based 3D printing process for…
3D printing of pharmaceutical formulations requires juggling between the material properties and the printing process to achieve the geometry of the 3D printed products with the desired dose and release. The purpose of the current…
A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the…
Fenofibrate is an effective lipid-lowering drug; however, its poor solubility and high log p (5.2) result in insufficient absorption from the gastrointestinal tract, leading to poor bioavailability. In this study, a one-step continuous…
Understanding the nanotechnology in COVID-19 vaccines
By Rumiana Tenchov, Information Scientist, CAS Posted February 18, 2021
Lipid nanoparticles are a vital component of the new Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines, playing a key role in protecting and transporting the mRNA…
Sigachi Industries Site In Isnapur, India Receives EXCiPACT GMP Certification As Pharmaceutical…
Brussels, 23 February 2021
EXCiPACT asbl announced that the Sigachi Industries Ltd site in Pashammailaram, Isnapur,
India has recently been awarded an EXCiPACT GMP certificate from SGS, one of EXCIPACT’s internationally
recognised…
4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80
Introduction
Polysorbates (PS) are used in biopharmaceuticals to stabilize therapeutic proteins. Oxidative degradation of (poly)unsaturated fatty acids (PUFAs) contained in PS was shown to lead to α,β-unsaturated carbonyls.
Aim…
Glatt Pharmaceutical Services and Aprecia to Advance Patient Focused Pharmaceuticals with Aprecia’s…
BINZEN, Germany and CINCINNATI, Ohio —Glatt Pharmaceutical Services and Aprecia announce their joint effort to accelerate and expand the use of Glatt’s multiparticulate technologies through Aprecia’s 3DP manufacturing. This unprecedented…
Towards the Development of Long Circulating Phosphatidylserine (PS)- and Phosphatidylglycerol…
The anionic phospholipids (PLs) phosphatidylserine (PS) and phosphatidylglycerol (PG) are endogenous phospholipids with anti-inflammatory and immunomodulatory activity. A potential clinical use requires well-defined systems and for several…
Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation
The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments,…
Measuring Saturation Solubility in Lipid Excipients
Obtaining solubility data in a sufficiently broad range of lipid excipients is the first step towards the development of a lipid-based formulation. Solubility is an indication of expected drug load and performance of the formulation.…
Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery…
The biocompatible nature of mesoporous silica nanoparticles (MSN) attracted researchers’ attention to deliver therapeutic agents in the treatment of various diseases, where their porous nature, high drug loading efficiency, and suitability…
Electrospraying: A facile technology unfolding the chitosan based drug delivery and biomedical…
Chitosan (CS) a promising biopolymer has been explored for wide biomedical applications using different technologies. Electrospraying is one of the advancing liquid atomization-based techniques rapidly merging in fields of biomedicine,…
Enabling Oral Amphotericin B Delivery by Merging the Benefits of Prodrug Approach and…
Amphotericin B (AmB) is gold standard therapy for leishmaniasis and fungal infections. Considering the global disease burden, nearly 90% of cases occur in economically vulnerable countries, making the cost of AmB therapy a critical…
Nanoemulsion-based patch for the dermal delivery of ascorbic acid
Photo-aging is caused mainly by sun radiations, which consist mainly of the ultraviolet radiation (UVA and UVB). Ascorbic acid (AA) has been widely used in the cosmetic field as an anti-wrinkle, anti-pigmentary, and antioxidant agents,…
Continuous Mixing Technology: Characterization of a vertical mixer using residence time distribution
Continuous powder mixing technology (CMT) application during continuous direct compression has emerged as a leading technology used in the development and manufacture of solid oral dosage forms. The critical quality attributes of the…
Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet
The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for the treatment of gastroesophageal reflux disease. Rabeprazole sodium is a commonly prescribed proton pump…
Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral…
Purpose: To enhance the oral bioavailability of revaprazan (RVP), a novel solid, supersaturable micelle (SSuM) was developed.
Methods: Surfactants and solid carriers were screened based on a solubility and a flowability test,…
Stress-Dependent Particle Interactions of Magnesium Aluminometasilicates as Their Performance Factor…
In the pharmaceutical industry, silicates are commonly used excipients with different application possibilities. They are especially utilized as glidants in low concentrations, but they can be used in high concentrations as porous carriers…
Advancing the understanding of the tablet disintegration phenomenon – an update on recent…
Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental quality attribute of immediate release tablets.…
In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for…
In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the…