Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Formulation and Delivery Technologies for mRNA Vaccines
mRNA vaccines have become a versatile technology for the prevention of infectious diseases and the treatment of cancers. In the vaccination process, mRNA formulation and delivery strategies facilitate effective expression and presentation…
3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine
3D printing and nanotechnology have been two important tools in the development of therapeutic approaches for personalized medicine. More recently, their alliance has been improved in an effort to build innovative, versatile,…
Development of vaccine formulations: past, present, and future
The current situation, heavily influenced by the ongoing pandemic, puts vaccines back into the spotlight. However, the conventional and traditional vaccines present disadvantages, particularly related to immunogenicity, stability, and…
Effect of Eudragit® NE 40D on The Properties of Pectin Film-Based Polymer Blends
In this work, pectin was used as the primary polymer component while Eudragit® NE 40D was used as polymer blending for the preparation of the thin films. Glycerin was used as a plasticizer. The samples were prepared by a solvent casting…
Interaction of Polymers with Enzalutamide Nanodroplets – Impact on Droplet Properties and…
Amorphous solid dispersions (ASDs), which consist of a drug dispersed in a polymeric matrix, are increasingly being applied to improve the in vivo performance of poorly water-soluble drugs delivered orally. The polymer is a critical…
Application of mini ODTs and coin shaped ODTs with high performance excipients for pediatric…
Pediatric formulations are strongly demanded from healthcare professionals and caregivers. Currently, solid dosage forms have been studied as pediatric preparations.
In this article, we report the development of orally disintegrating…
Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed…
In pharmaceutical wet granulation, drying is a critical step in terms of energy and material consumption, whereas granule moisture content and size are important process outcomes that determine tabletting performance. The drying process is,…
Investigations of process parameters during dissolution studies of drug loaded 3D printed tablets
The present research paper attempts to study the effect of different process parameters on the dissolution rate during 3D printed tablets. Three-dimensional printing has the potential of serving tailored made tablets to cater personalized…
In Situ Self-Assembly Nanomicelle Microneedles for Enhanced Photoimmunotherapy via Autophagy…
Although certain therapeutic agents with immunogenic properties may enhance antitumor immunity, cancer cells can eliminate harmful cytoplasmic entities and escape immunosurveillance by orchestrating autophagy. Here, an ingenious in situ …
Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System…
A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen in this study as a new potential Ocular Drug Delivery System (ODDS) for Cyclosporine-A (CyA), a poorly water-soluble drug. Two…
Microemulsion-Based Media in Nose-to-Brain Drug Delivery
Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one. Due to the unique anatomical features of the nasal cavity, drugs administered…
In-vitro/In-vivo Evaluation of Paclitaxel Freeze-Dried Micellar Nanoparticles Intended for Buccal…
Biopharmaceutics Classified drugs in the category II, III and IV encounter many challenges during development of buccal formulations with adequate bioavailability. This study took the advantage of nanoparticles based on permeability…
Enhancing in vitro cytotoxicity of doxorubicin against MCF-7 breast cancer cells in the presence of…
This study was aimed to evaluate the impact of water-soluble β-cyclodextrin polymer (β-CDP), as a nanocarrier, on the therapeutic efficacy of the commercial doxorubicin (DOX). The β-CDP was synthesized by cross-linking of β-CD using…
Brittle polymers in Fused Deposition Modeling: An improved feeding approach to enable the printing…
Brittleness is often described as a restricting material property for the processability of filaments via Fused Deposition Modeling. Especially filaments produced from approved pharmaceutical polymers often tend to fracture between feeding…
Impact of excipients on batch and continuous powder blending
Stimulated by Pharma 4.0, the pharmaceutical industry is changing from batch-wise to continuous manufacturing. Therefore, individual processing steps such as blending of the active pharmaceutical ingredient (API) with excipients have to be…
Evaluation of Binders in Twin-Screw Wet Granulation
The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL‑SFP, HPC SSL, and HPC SL‑FP) were evaluated regarding their suitability in twin-screw wet granulation. Six…
CDMO for PolyAmino Acids – PMC Isochem
Why a PAA based delivery technology?
Growing interest for advanced biomedicines!
Polyamino acids (PAAs)-based materials have gained much attention in the field of biomedicine as they demonstrate remarkable biocompatibility and…
ExciPerience 2021- The complete overview and explanation of the new event for pharmaceutical…
What is the ExciPerience?
ExciPerience 2021 was the new virtual event around every aspect of pharmaceutical excipients. ExciPerience covered all areas from basic or advanced research and formulation to manufacturing and regulatory. It…
Generation of Ophthalmic Nanosuspension of Prednisolone Acetate Using a Novel Technology
Purpose
Prednisolone Acetate (PAC) is currently marketed as micronized ophthalmic suspension. The microsuspension has poor dose accuracy and efficacy due to aggregation, slow dissolution rate and limited corneal residence. The ophthalmic…
In situ forming and mucoadhesive ophthalmic voriconazole/HPβCD hydrogels for the treatment of fungal…
Fungal keratitis is a severe infectious corneal disease. At present, no voriconazole ophthalmic formulations are approved by the FDA or EMA. This lack of therapeutic options leads to the reformulation of intravenous voriconazole…
3D-printing of solid lipid tablets from emulsion gels
Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need for personalized medicines. Most research to date has focused on printing of polymeric-based drug delivery systems at high…
Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of…
Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble drugs, where the maintenance of supersaturation plays a key role in enhancing the absorption process.…
Electrosprayed mucoadhesive alginate-chitosan microcapsules for gastrointestinal delivery of…
Besides viability protection, a sufficiently prolonged gastrointestinal retention of probiotics has emerged as critically important in improving the functional effectiveness of gastrointestinal delivery of these microorganisms. In this…
A novel combination of Soluplus ®/Poloxamer for Meloxicam solid dispersions via hot melt extrusion…
Objective: Bioavailability of Meloxicam (MLX) from solid dispersions (SDs), against innovator product Mobic® in humans was conducted. Furthermore, to establish a good in vitro-in vivocorrelation (IVIVC); dissolution studies were carried-out…
A novel combination of Soluplus® and Poloxamer for Meloxicam solid dispersions via hot melt…
The hot melt extrusion (HME) technique was proposed to prepare solid dispersions (SDs) of the high melting point meloxicam (MLX) for the first time. Extruded MLX/SDs (EXT) prepared by HME were compared with fusion (FUS) and physical mixture…
The Use of Phospholipids to Make Pharmaceutical Form Line Extensions
This review describes the use of phospholipid excipients to make Pharmaceutical Form (Dosage Form) Line Extensions of existing drugs as part of a Product Life Cycle Management. We provide product examples and development candidates, which…
Exploring the Interplay between Drug Release and Targeting of Lipid-Like Polymer Nanoparticles…
Targeted delivery of doxorubicin still poses a challenge with regards to the quantities reaching the target site as well as the specificity of the uptake. In the present approach, two colloidal nanocarrier systems, NanoCore-6.4 and…
Formulation and optimisation of lamivudine‐loaded Eudragit® S 100 polymer‐coated pectin microspheres…
This investigation is to find a prolonged or delayed drug release system, exclusively for the treatment of hepatitis‐B to reduce the side effects, which arise when conventional solid dose forms are administered. To pursue this goal,…
Co-Processed Excipients for Dispersible Tablets—Part 2: Patient Acceptability
Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of excipients and manufacturing techniques. The aim…
ZoomLab™ features now the Developability Classification of Active Ingredients
With ZoomLab™‘s newest module, formulators can determine the Developability Classification System (DCS) class of active pharmaceutical ingredients for oral dosage forms.
With the Developability Classification of Active Ingredients…
Influence of temperature on the packing dynamics of polymer powders
Temperature influences drastically the physical properties of polymer powders. In the present study, the packing dynamics of polymer powders has been investigated with a modified version of GranuPack instrument, which is an improvement of…
Loss-in-weight feeding, powder flow and electrostatic evaluation for direct compression…
Minimizing variability in the feeding process is important for continuous manufacturing since materials are fed individually and can impact the final product. This study demonstrates the importance of measuring powder properties and…
Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production…
Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bioavailability of drugs can be solved by the design of suitable delivery systems based on the combination of two pillar classes of ingredients:…
Challenges of Dissolution Methods Development for Soft Gelatin Capsules
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs. This is attributed to the increased number of poorly soluble drugs in the…