Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Excipients in Pharmaceutical Additive Manufacturing: A Comprehensive Exploration of Polymeric…
Abstract
This review provides a comprehensive overview of additive manufacturing (AM) or 3D-printing (3DP) applications in the pharmaceutical industry, with a particular focus on the critical role of polymer selection. By providing…
Asahi Kasei offers pharmaceutical excipient Ceolus™ with nitrite concentration of 0.1 ppm or less
PRESS RELEASE
February 27, 2024, Asahi Kasei Corp.
Contributing to lower risk of potentially carcinogenic nitrosamine impurities in pharmaceuticals
To contribute to reducing the risk of potentially carcinogenic nitrosamine impurities…
Impact of dry coating lactose as a brittle excipient on multi-component blend processability
Abstract
Previous work demonstrated the benefits of dry coating fine-grade microcrystalline cellulose (MCC) for enabling direct compression (DC), a favored tablet manufacturing method, due to enhanced flowability while retaining good…
A Comprehensive Review on Pharmaceutical Ready premix Coating Powder
Coating is an essential process in the pharmaceutical and nutraceutical industry. Earlier pharmaceutical formulation companies used to buy separate ingredients and mix them for colour coating, but nowadays many manufacturers are involved in…
The Past, Present, and Future of Oral Dosage Forms for Children
Abstract
The administration of medications to children has been a challenge for parents and caregivers for generations. Pharmaceutical companies have often overcome the difficulties of weight-based dosing and the inability of most young…
Third-Generation Solid Dispersion Through Lyophilization Enhanced Oral Bioavailability of…
Resveratrol (RES) is a biopharmaceutical classification system (BCS) class II compound with low solubility and high permeability. Several strategies have been explored to overcome the low bioavailability of RES, making the formation of…
Interactions between multifunctional pharmaceutical excipients and efflux pump for optimal drug…
Polymeric excipients ensure the site-specific delivery of the drug at the desired rate for a specified duration to achieve better efficacy. Pharmaceutical excipients were supposed to be pharmacologically inert, and must assure a controlled…
Meet Customer Demand with Plant-Based ADM Excipients and API
The trend toward products with plant-based ingredients continues to grow as a result of customer demand. ADM can help you with high quality, low toxicity ingredients that are cost-effective, bio-compatible and easily available.
In…
Towards safer and efficient formulations: Machine learning approaches to predict drug-excipient…
Abstract
Predicting drug-excipient compatibility is a critical aspect of pharmaceutical formulation design. In this study, we introduced an innovative approach that leverages machine learning techniques to improve the accuracy of…
Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation – Where Are We…
Abstract
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The…
Colon-targeted delivery systems of budesonide as second-line therapy in inflammatory bowel disease
Abstract
In inflammatory bowel disease (IBD), some parts of the gastrointestinal tract GIT become inflamed, depending on the location of the inflammation, it's divided into two types Crohn's and ulcerative colitis (UC). The local…
Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior
Abstract
Twin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the kneading zone for granule growth to happen highlighting the critical role played by the kneading elements in TSMG. Despite extensive…
Some Applications of Arthrospira platensis and Algae in Pharmaceutical and Food Technologies
Abstract
Algae, as well as Arthrospira platensis, have a wide range of biologically active constituents that determine different pharmacological properties. They are also the basis for developing various new nutritional compositions and…
Fabrication and Optimization of Directly Compressible Self-Emulsifying Tablets Containing Cannabis…
Δ9-Tetrahydrocannabinol and cannabidiol, which are present in cannabis extract, exhibit low bioavailability when administered orally due to significant first-pass metabolism. The use of a self-emulsifying drug delivery system (SEDDS) can…
Dry Granulation in Solid Oral Formulation: Advantages of Spray-Dried Mannitol in Roll Compaction
The Application of Fillers and Binders in Solid Dosage Formulation
Pharmaceutical excipients are frequently used as fillers and fillers/binders in the formulation of solid dosage forms. Fillers add volume and confer mechanical properties…
Surfactants for stabilization of dermal emulsions and their skin compatibility under UVA…
Phospholipids are versatile formulation compounds with high biocompatibility. However, no data on their effect on skin in combination with UVA radiation exist. Thus, it was the aim of this work to (i) develop o/w nanoemulsions (NEs)…
Statistically developed stable Camptothecin-loaded Soluplus/TPGS mixed micelles for improved ovarian…
In this research, Camptothecin-loaded mixed micelles (CPT-MMs) were formulated by combining Soluplus®, a novel amphiphilic excipient, with D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). The use of appropriate excipients is…
Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for…
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a novel and potential oral therapeutic option for ulcerative…
Application of 3D printing in early phase development of pharmaceutical solid dosage forms
Abstract
Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with…
Sustainably sourced Squalene – by Croda
Non-shark derived, engineered by synthetic biology. Our pharmaceutical-grade Squalene has superior purity, naturally setting it apart on the market.
An innovative alternative to shark-derived squalene using synthetic biology
There…
Impact of the polymer dispersity on the properties of curcumin/polyvinylpyrrolidone amorphous solid…
Amorphous solid dispersions (ASD) are known to enhance the absorption of poorly water-soluble drugs. In this work we synthesise well-defined Polyvinylpyrrolidone (PVP) to establish the impact of dispersity and chain-end functionality on the…
In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection
Abstract
Capsaicin (CAP) has been implicated as a gastroprotective agent in the treatment of peptic ulcers. However, its oral administration is hampered by its poor aqueous solubility and caustic effect at high administered doses. To…
Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct…
The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on…
KLEPTOSE® BioPharma Hydroxypropyl Beta-Cyclodextrin as a Potential Functional Alternative to…
Roquette presented a new case study lately. See the use of KLEPTOSE® BioPharma Hydroxypropyl Beta-Cyclodextrin as a potential functional alternative to surfactants in the following:
CHALLENGE
Therapeutic proteins are inherently unstable…
Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and…
Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable from an economic and ecological perspective but also limited to thermostable active pharmaceutical ingredients (APIs). A potential technology shift from…
Influence of preparation method and choice of phospholipid on co-amorphization, physical stability,…
This case study aimed to evaluate the feasibility of forming equimolar co-amorphous drug-phospholipid systems by different preparation methods. Indomethacin (IND) was chosen as a model drug and combined with three phospholipids of natural…
Solid dispersions of bedaquiline fumarate to improve its pharmaceutical attributes: A comparative…
Abstract
Objectives
The therapeutic delivery of hydrophobic drugs via solid dispersion is an appealing methodology to enhance the dissolution rate and ultimately the in vivo bioavailability. The objective of current investigation was to…
Impact testing as a new approach to determine mechanical strength of pharmaceutical tablets
Abstract
One of the most common standardised testing of tablet strength in the pharmaceutical industry is the tablet breaking force, which records data related to diametrical compression. This method does not account for a rapid transfer…
Development of multiple structured extended release tablets via hot melt extrusion and dual-nozzle…
Abstract
The study aims to fabricate extended release (ER) tablets using a dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing technology based on hot melt extrusion (HME), using caffeine as the model compound.…
Biopolymer Packaging Materials in the Pharmaceutical Industry
Biopolymer packaging materials are gaining prominence in the pharmaceutical industry due to environmental concerns. Derived from renewable sources, these biopolymers offer biodegradability, biocompatibility, and non-toxicity, making them…
Hypericin emulsomes combined with hollow microneedles as a non-invasive photodynamic platform for…
Rheumatoid arthritis (RA) is a joint-destructive autoimmune disease that severely affects joint function. Despite the variability of treatment protocols, all of them are associated with severe side effects that compromise patient…
Advancing oral drug delivery: The science of fast dissolving tablets (FDTs)
The field of oral drug delivery has witnessed significant advancements, with a focus on developing innovative formulations to address challenges associated with traditional dosage forms, especially for patients with difficulties in…
Recent advances of electrospray technique for multiparticulate preparation: Drug delivery…
Abstract
The electrospray (ES) technique has proven to be an effective and a versatile approach for crafting drug delivery carriers with diverse dimensions, multiple layers, and varying morphologies. Achieving the desired particle…
Leveraging novel innovative thermoresponsive polymers in microneedles for targeted intradermal…
Abstract
Microneedles have garnered considerable attention over the years as a versatile pharmaceutical platform that could be leveraged to deliver drugs into and across the skin. In the current work, poly (N-isopropylacrylamide) (PNIPAm)…