Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Microemulsion-Based Media in Nose-to-Brain Drug Delivery
Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one. Due to the unique anatomical features of the nasal cavity, drugs administered…
Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring
The increasing prevalence of colonic diseases calls for a better understanding of the various colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools that accurately predict local drug disposition.…
Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation…
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet…
A grafted copolymer-based nanomicelles for topical ocular delivery of everolimus: Formulation,…
Treatment of posterior uveitis via topical route is desirable but cannot be achieved by conventional drug delivery strategies. Therefore, the aim of this study is to develop a topical nanomicellar formulation of an immunosuppressant drug,…
Spray Drying for Direct Compression of Pharmaceuticals
Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to…
Webinar: galenIQ™ – Ask the expert: How to formulate medicine that tastes better?
Thursday, 4 March 2021 – 02:30 PM CET
In this webinar, you can ask the experts from BENEO everything you always wanted to know about galenIQ™.
Recent trends show that patients and consumers want to take their medicine and nutritional…
Co-Processed Excipients for Dispersible Tablets–Part 1: Manufacturability
Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterise a range of co-processed excipients that may…
Effects of polyvinylpyrrolidone (K90) on membrane permeation via the transcellular route in the rat…
Although pharmaceutical excipients do not affect the membrane permeation of active drugs, some have been shown to influence absorption-regulating factors. However, limited information is currently available on the effects of pharmaceutical…
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific…
CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can…
Investigation of the in situ thermal conductivity and absorption behavior of nanocomposite powder…
One of the AM processes for direct manufacturing of metallic components is powder bed fusion of metals using a laser beam system (PBF-LB/M), in which metallic powders are molten and solidified in a layer upon layer manner by a focused laser…
IFF to Complete Merger With DuPont’s Nutrition & Biosciences Business
NEW YORK--(BUSINESS WIRE)--IFF (NYSE: IFF) to complete the previously announced merger of IFF and DuPont’s Nutrition & Biosciences (“N&B”) business, pursuant to a Reverse Morris Trust transaction today. The combined company will…
Powder Properties and Flowability Measurements of Tailored Nanocomposites for Powder Bed Fusion…
The modification of metal alloy powders by coating with nanoparticles offers the possibility to improve additive manufacturing processes, in particular the powder bed fusion of metals with laser beams (PBF/LB-M), from the material side of…
Quaternary polymethacrylate−magnesium aluminum silicate film formers: Stability studies for tablet…
The objective of this work was to investigate the long-term stability of quaternary polymethacrylate-magnesium aluminum silicate (QPM-MAS) nanocomposite film-coated tablets compared to that of QPM-coated tablets. QPM- and QPM-MAS-coated…
Advanced applications of green hydrogels in drug delivery systems
Hydrogels are the versatile three-dimensional (3D), crosslinked polymeric networks that have demonstrated numerous vital functions in several scientific domains.
Various inherent, structural features of hydrogels have fascinated the…
Self-Emulsifying Drug Delivery System: A Novel Approach for Oral Delivery of Poorly Water Soluble…
Self nano emulsifying drug delivery systems (SNEDDs) gained much attention in the last decades since, such systems considered one of the most favorable and efficient approaches to enhance solubility, increase drug absorption and hence,…
Development of Biodegradable Films Loaded with Phages with Antilisterial Properties
The inhibitory and bactericidal capacity of Listex P100 bacteriophage has been studied against different concentrations of Listeria monocytogenes in stationary and exponential phases. Three different matrices were employed to developed…
IID-Listed Ingredients for Topical Drug Delivery
Topical formulations can effectively deliver therapeutics to a targeted area, with the added benefits of convenient application and reduced risk of systemic side effects. Due to these advantages, it should come as no surprise that this area…
Characterization and Applications of Colloidal Systems as Versatile Drug Delivery Carriers for…
Preparing a suitable formulation for parenteral administration is already a difficult task; this, coupled with poor water-soluble new chemical entity (NCE), complicates this situation even further. There are several methodologies available…
Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid…
Breviscapine (BVP), a flavonoid compound, is widely used in the treatment of cardiovascular and cerebrovascular diseases; however, the low oral bioavailability and short half-life properties limit its application. The aim of this study was…
World Cancer Day 2021 – Functional Solutions for Oncology Pharmaceuticals
"World Cancer Day every 4 February is the global uniting initiative led by the Union for International Cancer Control (UICC). By raising worldwide awareness, improving education and catalysing personal, collective and government action,…
Elucidation of mass transfer mechanisms in pellet formation by spheronization
Previously published mechanisms of pellet formation during extrusion-spheronization include a transfer of material between different granules. This research aimed to specify the origin of this transfered mass, enabling further insight into…
Comprehensive study of co-processed excipients F- Melts®: Flow, viscoelastic and compacts properties
This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts® type C,M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were…
Impact of incorporated drugs on material properties of amorphous solid dispersions
Formulation development of amorphous solid dispersions (ASD) still is challenging although several poorly water-soluble drugs have been marketed using this technique. During development of novel drugs, the selection of the preparation…
See the new features of the digital formulation assistant ZoomLab™ in February 2021
BASF has released a new version of the digital tool, ZoomLab™ in February 2021. The latest update includes a “Developability Classification of Active Ingredient” module and an expanded “Excipient Database” with 44 new topical excipients. …
In Situ-Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In…
In this work, sucrose acetate isobutyrate (SAIB) and polylactic co-glycolic acid (PLGA) were used alone or in combination as a matrix-former (MF) to prepare long-acting injectable rivastigmine (RV) in situ-forming microparticles (ISM).…
Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System…
A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen in this study as a new potential Ocular Drug Delivery System (ODDS) for Cyclosporine-A (CyA), a poorly water-soluble drug. Two…
Amorphous Drug–Polymer Salt with High Stability under Tropical Conditions and Fast Dissolution: The…
We report that the stability of amorphous clofazimine (CFZ) against crystallization is vastly improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry method was used to produce the amorphous salt of…
Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached…
Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and…
Recent Advances in miRNA Delivery Systems
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription. MiRNAs hybridize to target mRNA(s) to induce…
Development of Extended-Release Formulation of Ibuprofen Using Blends of Calcium Silicate and…
A tablet matrix system was developed for ibuprofen and the influence of the polymer blend and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of calcium silicate and PVP (polyvinyl…
The beneficial activity of curcumin and resveratrol loaded in nanoemulgel for healing of…
Burns are complicated wounds characterized by prolonged and persistent inflammatory phase. The combination of nutraceuticals in nano-delivery systems is hypothesized to enhance therapeutic efficacy and achieve better healing outcome. In…
Engineering biopharmaceutical formulations to improve diabetes management
Insulin was first isolated almost a century ago, yet commercial formulations of insulin and its analogs for hormone replacement therapy still fall short of appropriately mimicking endogenous glycemic control. Moreover, the controlled…
Application of data-intelligence algorithms for modeling the compaction performance of new…
Pharmaceutical excipient development is an extensive process requiring a series of pre-formulation studies to evaluate their performance. The present study compares the conventional compaction and compression pre-formulation studies with…
Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets
Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral…